| Little Fuller Brook | |
| Pushpin Map: | New York |
| Pushpin Map Caption: | Location of the mouth of Little Fuller Brook |
| Subdivision Type1: | Country |
| Subdivision Name1: | United States |
| Subdivision Type2: | State |
| Subdivision Name2: | New York |
| Subdivision Type4: | County |
| Subdivision Name4: | Delaware |
| Source1 Coordinates: | 42.0162°N -74.9624°W |
| Mouth: | Horton Brook |
| Mouth Coordinates: | 42.0034°N -75.0027°W[1] |
| Mouth Elevation: | 1512feet |
Little Fuller Brook is a river in Delaware County, New York. It flows through Edwards Pond before converging with Horton Brook north-northeast of Horton.