| Little Doe River | |
| Source1 Location: | Simerly Creek and Tiger Creek |
| Mouth Location: | Doe River |
| Subdivision Type1: | Country |
| Subdivision Name1: | United States |
| Subdivision Type2: | State |
| Subdivision Name2: | Tennessee |
| Source1 Elevation: | 1788feet |
The Little Doe River is a river located in Carter County, Tennessee. It forms from the confluence of Simerly Creek and Tiger Creek near the community of Tiger Valley, and runs in a northerly direction alongside U.S. Route 19E until its termination into Doe River just south of the town of Hampton, Tennessee.