| Little Cholame Creek | |
| Pushpin Map: | USA California |
| Pushpin Map Size: | 300 |
| Pushpin Map Caption: | Location of the mouth of Little Cholame Creek in California |
| Subdivision Type1: | Country |
| Subdivision Name1: | United States |
| Subdivision Type2: | State |
| Subdivision Name2: | California |
| Subdivision Type3: | Region |
| Subdivision Name3: | Monterey County |
| Subdivision Type5: | City |
| Subdivision Name5: | Parkfield, California |
| Length: | 8miles |
| Source1: | On the southern flank of an unnamed peak in the southern part of the Diablo Range |
| Source1 Coordinates: | 35.9869°N -120.5192°W[1] |
| Source1 Elevation: | 2690feet |
| Mouth: | Parkfield, California |
| Mouth Coordinates: | 35.9089°N -120.5192°W |
| Mouth Elevation: | 1560feet |
| Tributaries Left: | Reason Mountain, Pine Canyon Creek, Joaquin Canyon Creek |
| Tributaries Right: | Middle Mountain Ridge |
Little Cholame Creek is a perennial stream in southeastern Monterey County, California, United States. The headwaters rise from an unnamed peak 2miles southwest of Reason Mountain, in the southern part of the Diablo Range. From there, the creek flows southeast along Parkfield-Coalinga Road, before reaching confluence with Cholame Creek.
"Cholame" is a Yokuts Native American word meaning "the beautiful one". The creek runs through the northern part of Cholame Valley, along Parkfield-Coalinga Road, and on through the small town of Parkfield before crossing the San Andreas Fault and merging with Cholame Creek.