List of target antigens in pemphigoid explained

See also: List of cutaneous conditions.

Circulating auto-antibodies in the human body can target normal parts of the skin leading to disease. This is a list of antigens in the skin that may become targets of circulating auto-antibodies leading to the various types of pemphigoid.

Target antigens for the different pemphigoid variants
Pemphigoid variant			Molecular weight (KDa)
	IgG, IgE^[1]		180 230
			180 230
			180
			200
Antiepiligrin cicatricial pemphigoid^[2]		Laminin 5 (Epiligrin, Laminin 332)
		LAD1 portion of BPAG2 Collagen type VII	97 290/145
			105

Of note, there are also several other diseases that are caused by auto-antibodies that target the same anatomic area of the skin which is termed the basement membrane zone. These diseases include:

Target antigens for the different autoimmune bullous conditions targeting the basement membrane zone of the human integumentary system, excluding pemphigoid
Disease			Molecular weight (KDa)
			290/145
			290/145
Lichen planus pemphigoides^[3]			180

Footnotes

Successful Treatment of Bullous Pemphigoid with Omalizumab. 10.1001/archdermatol.2012.1604. 2012. London. Vanessa A.. Kim. Gene H.. Fairley. Janet A.. Woodley. David T.. Archives of Dermatology. 148. 11. 1241–1243. 23165827.
The antiepiligrin variant of cicatricial pemphigoid is associated with gastric cancer.
In this condition bullae develop on skin already affected by lesions of lichen planus as well as on areas of skin without lesions of lichen planus.

References

Book: Bolognia, Jean L.. Dermatology . Mosby . St. Louis . 2007 . 978-1-4160-2999-1 . etal.
Book: James, William D.. Andrews' Diseases of the Skin: Clinical Dermatology . Saunders Elsevier . 2006 . 0-7216-2921-0 . etal.