This article provides a listing, with brief descriptions, of the most traveled or best known streets and thoroughfares in Ponce, Puerto Rico. Unless otherwise noted, traffic is two-way. If traffic is two-way for the entire length of the street (as opposed to just a portion of its length), it is designated with the symbol "↔" under the column "Traffic direction"; otherwise, the dash symbol ("–") is used.
| Name | Southern or western terminus | Northern or eastern terminus | Length, mi (km) | of lanes | Traffic direction | Notes | Photo | |
|---|---|---|---|---|---|---|---|---|
| Avenida Fagot | Bulevar Miguel Pou | Puerto Rico Highway 10 | 3miles | 4 | S ↔ N | Southern terminus becomes Avenida Las Américas at Bulevar Miguel Pou | ||
| Avenida Hostos | Plaza de Recreo de la Playa | Calle Ferrocarril | 2.5miles | 2 | S ↔ N | — | ||
| Avenida Las Américas | Puerto Rico Highway 500 | Bulevar Miguel Pou | 3miles | 6 | W ↔ E | Northern terminus becomes Avenida Fagot at Bulevar Miguel Pou | ||
| Avenida Muñoz Rivera | Puerto Rico Highway 2 | Avenida Las Américas | 0.5miles | 2 | S ↔ N | — | ||
| Avenida Santiago de los Caballeros | Port of Ponce | Avenida Tito Castro | 3.28miles | 4–6 | S ↔ N | Some segments are 4 lanes only | ||
| Avenida Tito Castro | Puerto Rico Highway 12 | Puerto Rico Highway 139 | 3miles | 4 | W ↔ E | Becomes Calle Betances at the bridge over Río Portugués, where it becomes a one-lane, westbound street | ||
| Bulevar Miguel Pou | Parque del Tricentenario / Puente de los Leones | Avenida Ednita Nazario | 1.5miles | 4 | W ↔ E | Eastern end turns into Ponce Bypass. | ||
| Calle Atocha | Calle Isabel | Calle Victoria | 0.1miles | 1 | S – N | Traffic is one-way northbound. | ||
| Calle Marina | Puerto Rico Highway 10 | 0.5miles | 2 | N – S | Traffic is one-way southbound from Calle Tricoche (i.e., 1 block north of PR-14) to Calle Marina (i.e., PR-123) | |||
| Calle Comercio | Plaza Las Delicias | Avenida Santiago de los Caballeros | 1.2miles | 1–2 | W – E | Traffic is eastbound from Plaza Las Delicias to Calle Cruz | ||
| Calle Isabel | Plaza Muñoz Rivera | Parque del Tricentenario | 0.4miles | 1–2 | E – W | Except for the one block from Plaza Muñoz Rivera to Calle León, traffic is one-way westbound. | ||
| Calle Marina | Calle Ferrocarril | Plaza Las Delicias | 0.4miles | 1–2 | S – N | Traffic is northbound one-way north of Calle Mayor to Plaza Las Delicias; South of Calle Mayor traffic is two-way; Southern end becomes Avenida Hostos at Calle Ferrocarril | ||
| Calle Villa | Bridge over Río Cañas at entrance to Urbanización Jardines del Caribe | Plaza Las Delicias | 2miles | 2 | W – E | Traffic is eastbound one-way from Carretera Pámpanos to Plaza Las Delicias | ||
| Calle 25 de Enero | Calle Villa | Residencial Santiago Iglesias | unknown | 1 | N – S | — | ||
| Carretera Pámpanos | Puerto Rico Highway 2 | Calle Villa | 1miles | 2 | S ↔ N | — | ||
| Ponce Bypass | Carretera Pámpanos | Avenida Ednita Nazario | 4miles | 6 | W ↔ E | Eastern end becomes Bulevar Miguel Pou. |