List of sex-hormonal aqueous suspensions explained

This is a list of known sex-hormonal crystalline aqueous suspension formulations. Brand names and developmental code names are in parentheses.

Single-drug formulations

Androgens

Estrogens

Progestogens

Others

Multi-drug formulations

Estrogens and progestogens

Estrogens and androgens

Estrogens, progestogens, and androgens

Non-sex-hormonal aqueous suspensions

Corticosteroids

Antipsychotics

See also

Notes and References

  1. Book: Alan C. Sartorelli. David G. Johns. Antineoplastic and Immunosuppressive Agents. 27 November 2013. Springer Science & Business Media. 978-3-642-65806-8. 181–.
  2. Book: William Llewellyn. Anabolics. 2011. Molecular Nutrition Llc. 978-0-9828280-1-4. 385–394.
  3. Book: Hermann M. Behre . Gerhard F. Weinbauer . Eberhard Nieschlag . Testosterone Buciclate . 471–480 . Shalender Bhasin . Henry L. Gabelnick . Jeffrey M. Spieler . Pharmacology, Biology, and Clinical Applications of Androgens: Current Status and Future Prospects . https://books.google.com/books?id=hurRyWje4DMC&pg=PA471 . 13 February 1996 . John Wiley & Sons . 978-0-471-13320-9 . Testosterone buciclate is applied intramuscularly as a microcrystalline aqueous suspension. [...] After air milling [...] of crystalline testosterone buciclate to a particle size of at least 75% in the range of 10 - 50 μm, the drug was [...] suspended in sterile, aqueous suspension vehicle [...]..
  4. Book: William Llewellyn. Anabolics. 2011. Molecular Nutrition Llc. 978-0-9828280-1-4. 314–322.
  5. Book: Hans Hermann Julius Hager. Walther Kern. Paul Heinz List. Hermann Josef Roth. Hagers Handbuch der Pharmazeutischen Praxis: Für Apotheker, Arzneimittelhersteller, Ärzte und Medizinalbeamte: Wirkstoffgruppen II Chemikalien und Drogen (A-AL). 29 July 2013. Springer-Verlag. 978-3-662-25655-8. 109, 141, 178.
  6. Book: Hans Schuermann. Rudolf Doepfmer. Fertilitätsstörungen beim Manne. 13 March 2013. Springer-Verlag. 978-3-642-94784-1. 260–.
  7. Book: Willibald Pschyrembel. Praktische Gynäkologie: für Studierende und Ärzte. 15 June 2011. Walter de Gruyter. 978-3-11-150424-7. 598, 600, 601.
  8. Book: AMA Drug Evaluations. registration. 1971. Americal Medical Association. 318.
  9. Book: Drug Topics Redbook. 1976. Topics Publishing Company. 580.
  10. Book: John Christian Krantz. Charles Jelleff Carr. Domingo M. Aviado. Krantz and Carr's Pharmacologic principles of medical practice: a textbook on pharmacology and therapeutics for students and practitioners of medicine, pharmacy, and dentistry. 1972. Williams & Wilkins. 1258. 9780683002928 .
  11. Book: Marion E. Howard. Modern Drug Encyclopedia and Therapeutic Index. 1949. Drug Publications. 697.
  12. Book: Vademecum International. 1959. J. Morgan Jones Publications.. 147.
  13. Book: Frederick H. Meyers. Ernest Jawetz. Alan Goldfien. Review of Medical Pharmacology. 1978. Lange Medical Pub.. 978-0-87041-151-9. 400.
  14. Book: Arthur Osol. Robertson Pratt. The United States dispensatory. 1973. Lippincott. 978-0-397-55901-5. 498. The following dosages for estradiol in the form of aqueous suspension injected intramuscularly, or pellets implanted subcutaneously, are recommended by a leading maunfacturer: Menopausal syndrome.—In average cases, 1 mg. intramuscularly 2 or 3 times weekly for 2 or 3 weeks; in more severe cases, 1 to 1.5 mg. Thereafter dosage is reduced to the minimum requirement, usually within the range of 0.5 to 1 mg. of estradiol twice weekly..
  15. Book: Louis Sanford Goodman. Goodman and Gilman's The Pharmacological Basis of Therapeutics. registration. 1980. Macmillan. 978-0-02-344720-4. 1428. Estradiol, U.S.P. (AQUADiOL, PROGYNON, others), is available in aqueous suspension containing 0.5 or 1 mg/ml for intramuscular injection and as 25-mg pellets for subcutaneous implantation. Various esters of estradiol (benzoate, cypionate, enanthate, propionate, undecylate, and valerate) are prepared in aqueous suspensions or oily solutions for slow release after intramuscular injection. These preparations contain 0.5 to 40 mg/ml and are sold under various trade names (DELESTROGEN, DEPO-ESTRADIOL, OVOCYLIN, many others). Polyestradiol phosphate (ESTRADURIN) is also available for intramuscular use in prostatic carcinoma. Various sulfate esters of Estrone, U.S.P., are available in tablets containing 0.75 to 6 mg (OGEN, others). These esters and estrone are also supplied under various trade names in aqueous suspension and oily solution containing 1 to 5 mg/ml for intramuscular injection..
  16. Book: Heinrich Kahr. Konservative Therapie der Frauenkrankheiten: Anzeigen, Grenzen und Methoden Einschliesslich der Rezeptur. 8 March 2013. Springer-Verlag. 978-3-7091-5694-0. 20–22.
  17. Web site: Estrone Suspension Medical Review . 6 July 2024.
  18. Garza-Flores J, Hall PE, Perez-Palacios G . Long-acting hormonal contraceptives for women . J. Steroid Biochem. Mol. Biol. . 40 . 4–6 . 697–704 . 1991 . 1958567 . 10.1016/0960-0760(91)90293-e . 26021562 .
  19. Gabelnick. Henry L.. Hall. Peter E.. Long-acting methods for fertility regulation. Journal of Controlled Release. 6. 1. 1987. 387–394. 0168-3659. 10.1016/0168-3659(87)90092-7.
  20. Antal. E. Dick. C. Wrightiii. C. Welshman. I. Block. E. Comparative bioavailability of two medroxyprogesterone acetate suspensions. International Journal of Pharmaceutics. 54. 1. 1989. 33–39. 0378-5173. 10.1016/0378-5173(89)90162-2.
  21. Book: Pharmacy International. 1950. McGraw-Hill International Corporation. 34.
  22. Garza-Flores J . Pharmacokinetics of once-a-month injectable contraceptives . Contraception . 49 . 4 . 347–59 . April 1994 . 8013219 . 10.1016/0010-7824(94)90032-9 .
  23. Bagade O, Pawar V, Patel R, Patel B, Awasarkar V, Diwate S . Increasing use of long-acting reversible contraception: safe, reliable, and cost-effective birth control . World J Pharm Pharm Sci . 3 . 10 . 364–392 . 2014 . 2278-4357 . 2019-06-09 . https://web.archive.org/web/20170810000242/http://www.wjpps.com/download/article/1412071798.pdf . 2017-08-10 . dead .
  24. Book: Ufer . Joachim . Die therapeutische Anwendung der Gestagene beim Menschen . Therapeutic Use of Progestagens in Humans . 1026–1124 . 10.1007/978-3-642-99941-3_7 . Die Gestagene . Progestogens . 1968 . Springer-Verlag . 978-3-642-99941-3 . C. Dysfunktionelle Uterusblutungen. [...] 1. Depotinjektionen. 1. Originalmethode nach KAUFMANN und OBER. Es wird 1 Amp. mit 200 mg Progesteron und 10 mg Oestradiol-Monobenzoat als Kristallsuspension (Sistocyclin) injiziert [676, 678, 679, 295, 482, 365, 434, 563, 400]. [...] Beispiele. KAUFMANN et al. [485]: 400 mg Progesteron + 20 mg Oestradiolmonobenzoat Kristallsuspension. ELERT [224] U. HERRMANN [363]: 200 mg Progesteron + 10 mg Oestradiolmono benzoat Kristallsuspension..
  25. Web site: Archived copy . www.indufar.com.py . 15 January 2022 . https://web.archive.org/web/20200818223302/http://www.indufar.com.py/files/shares/prospectos/400000154.pdf . 18 August 2020 . dead.
  26. Sang GW . Pharmacodynamic effects of once-a-month combined injectable contraceptives . Contraception . 49 . 4 . 361–85 . April 1994 . 8013220 . 10.1016/0010-7824(94)90033-7 . The exact formulation and the size of the microcrystals is most important for duration of action. The smaller particles are more rapidly dissolved than larger ones and, hence, MPA appears more rapidly in the circulation, with more rapid elimination from the body. This is also true for the once-a-month formulation, Cyclofem. From our laboratory’s data, the distribution of particle size of Cyclofem is showed in Table 2. [...] TABLE 2. Distribution of particle size of crystalline steroids in Cyclofem (aqueous suspension). Size of particle (μm): ≤4: 0.3%. 5–6: 7.3%. 6–8: 16.7%. 8–10: 29.0%. 10–13: 29.7%. 13–16: 9.9%. 16–20: 0.5%. >20: 0.1%. [...] Mego-E, containing megestrol acetate 25 mg in combination with 3.5 mg 17B-estradiol in 1 ml of aqueous microcrystalline suspension with a defined particle size range, [...].
  27. Kubíková . Drahomíra . . Menopausal symptoms and hormone replacement therapy . cs . 2014 . Praktické Lékárenství . 10 . 2 . 68–73 . 1801-2434 . http://www.solen.sk/pdf/95e898d92100a736e32110dd1b846a9e.pdf-->.
  28. Book: Marek Josef. a kolektiv. Farmakoterapie vnitřních nemocí: 4., zcela přepracované a doplněné vydání. 14 May 2010. Grada Publishing a.s.. 978-80-247-9524-9. 380–. In addition, testosterone isobutyrate in FOLIVIRIN, Biotika, an injection containing 25 mg testosterone isobutyrate and 2.5 mg estradiol benzoate is available. It is applied every 4-6 weeks depending on the effect..
  29. Book: Georg Arends. Heinrich Zörnig. Hermann Hager. Georg Frerichs, Walther Kern. Hagers Handbuch der pharmazeutischen Praxis: Für Apotheker, Arzneimittelhersteller, Drogisten, Ärzte u. Medizinalbeamte. 14 December 2013. Springer-Verlag. 978-3-662-36329-4. 1163–.
  30. Book: Hormone und Psyche die Endokrinologie des Alternden Menschen: Fünftes Symposion der Deutschen Gesellschaft für Endokrinologie Freiburg (Breisgau), den 7. bis 9. März 1957. 9 March 2013. Springer-Verlag. 978-3-642-87014-9. 55–.

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