List of progestogens available in the United States explained

This is a list of progestogens (progesterone and progestins) and formulations that are approved by the in the United States. Progestogens are used as hormonal contraceptives, in hormone replacement therapy for menopausal symptoms, and in the treatment of gynecological disorders.

For contraception

See also: Hormonal contraception and Birth control.

Combined contraceptives

See also: Combined hormonal contraception.

Combined oral contraceptive pills

• Drospirenone and Estetrol (Nextstellis)
• Estradiol valerate and dienogest (Natazia)
• Ethinylestradiol and desogestrel (Bekyree, Cyclessa, Desogen, Emoquette, Enskyce, Isibloom, Kariva, Kimidess, Mircette, Ortho-Cept, Pimtrea, Velivet, Viorele, Volnea)
• Ethinylestradiol and drospirenone [and/or [[levomefolate calcium]]] (Beyaz, Loryna, Melamisa, Nikki, Safyral, Syeda, Yaela, Yasmin, Yaz)
• Ethinylestradiol and etynodiol diacetate (Demulen 1/35-21, Demulen 1/35-28, Demulen 1/50-21, Demulen 1/50-28, Kelnor, Zovia 1/35E-21, Zovia 1/35E-28, Zovia 1/50E-21, Zovia 1/50E-28)
• Ethinylestradiol and levonorgestrel (Alesse, Altavera, Ashlyna, Aviane-21, Aviane-28, Ayuna, Daysee, Elifemme, Enpresse-21, Enpresse-28, Falmina, Fayosim, Introvale, Kurvelo, Lessina-21, Lessina-28, Levlite, Levonest, Levonorgestrel and Ethinyl Estradiol, Levora 0.15/30-21, Levora 0.15/30-28, LoSeasonique, Lybrel, Marlissa, Myzilra, Nordette-21, Nordette-28, Orsythia, Portia-21, Portia-28, Preven Emergency Contraceptive Kit, Quartette, Quasense, Seasonale, Seasonique, Setlakin, Triphasil-21, Triphasil-28, Trivora-21, Trivora-28, Vienva)
• Ethinylestradiol and norethisterone [and/or [[ferrous fumarate]] (Fe)] (Alyacen 1/35, Alyacen 7/7/7, Alyacen 777, Aranelle, Balziva-21, Balziva-28, Brevicon 21-Day, Brevicon 28-Day, Briellyn, Cyclafem 0.5/35, Cyclafem 1/35, Cyclafem 7/7/7, Dasetta 1/35, Dasetta 7/7/7, Femcon Fe, Gencept 10/11-21, Gencept 10/11-28, Gildagia, Kaitlib Fe, Modicon 21, Modicon 28, N.E.E. 1/35 21, N.E.E. 1/35 28, Norcept-E 1/35 21, Norcept-E 1/35 28, Norethin 1/35E-21, Norethin 1/35E-28, Norinyl 1+35 21-Day, Norinyl 1+35 28-Day, Norquest Fe, Nortrel 0.5/35-21, Nortrel 0.5/35-28, Nortrel 1/35-21, Nortrel 1/35-28, Nortrel 7/7/7, Ortho-Novum 1/35-21, Ortho-Novum 1/35-28, Ortho-Novum 10/11-21, Ortho-Novum 10/11-28, Ortho-Novum 7/14-21, Ortho-Novum 7/14-28, Ortho-Novum 7/7/7-21, Ortho-Novum 7/7/7-28, Ovcon-35, Ovcon-50, Philith, Pirmella 1/35, Pirmella 7/7/7, Tri-Norinyl 21-Day, Tri-Norinyl 28-Day, Vyfemla, Wera)
• Ethinylestradiol and norethisterone acetate [and/or [[ferrous fumarate]] (Fe)] (Activella, Alyacen 1/35, Alyacen 7/7/7, Alyacen 777, Amabelz, Aranelle, Aurovela 1.5/30,^[1] Aurovela 1/20,^[2] Aurovela 24 Fe,^[3] Aurovela Fe 1.5/30,^[4] Aurovela Fe 1/20,^[5] Aurovela Fe,^[6] Aygestin, Balziva-21, Balziva-28, Blisovi 24 Fe,^[7] Blisovi Fe 1.5/30,^[8] Blisovi Fe 1/20,^[9] Brevicon 21-Day, Brevicon 28-Day, Briellyn, Camila, Chabelina Fe,^[10] Charlotte 24 Fe,^[11] Combipatch, Cyclafem 0.5/35, Cyclafem 1/35, Cyclafem 7/7/7, Cyonanz, Dasetta 1/35, Dasetta 7/7/7, Errin, Estrostep 21,^[12] Estrostep Fe,^[13] Femcon Fe, Femhrt,^[14] Finzala,^[15] Fyavolv,^[16] Gemmily,^[17] Gencept 10/11-21, Gencept 10/11-28, Gildagia, Gildess 1.5/30,^[18] Gildess 1/20,^[19] Gildess 24 Fe,^[20] Gildess Fe 1.5/30,^[21] Gildess Fe 1/20,^[22] Hailey 1.5/30,^[23] Hailey 24 Fe,^[24] Hailey Fe 1.5/30,^[23] Hailey Fe 1/20,^[25] Heather, Incassia, Jencycla, Jinteli,^[26] Junel 1.5/30,^[27] Junel 1/20, Junel 21,^[28] Junel Fe 1.5/30,^[27] Junel Fe 1/20,^[29] Junel Fe 24,^[30] Junel Fe 28,^[28] Kaitlib Fe, Larin 1.5/30,^[31] Larin 1/20,^[32] Larin 24 Fe,^[33] Larin Fe 1.5/30,^[34] Larin Fe 1/20,^[35] Leribane, Lo Larin Fe, Lo Loestrin Fe,^[36] Lo Minastrin Fe, Lo-Blisovi Fe, Loestrin 21 1.5/30, Loestrin 21 1/20, Loestrin 21,^[37] Loestrin 24 Fe,^[38] Loestrin Fe 1.5/30, Loestrin Fe 1/20, Loestrin Fe 28,^[37] Lomedia 24 Fe,^[39] Lupaneta Pack, Melodetta 24 Fe,^[40] Merzee,^[41] Mibelas 24 Fe, Microgestin 1.5/30, Microgestin 1/20, Microgestin Fe 1.5/30, Microgestin Fe 1/20, Micronor, Minastrin 24 Fe, Modicon 21, Modicon 28, Myfembree, N.E.E. 1/35 21, N.E.E. 1/35 28, Nexesta Fe, Nor-Qd, Norcept-E 1/35 21, Norcept-E 1/35 28, Norethin 1/35E-21, Norethin 1/35E-28, Norethin 1/50M-21, Norethin 1/50M-28, Norinyl, Norinyl 1+35 21-Day, Norinyl 1+35 28-Day, Norinyl 1+50 21-Day, Norinyl 1+50 28-Day, Norinyl 1+80 21-Day, Norinyl 1+80 28-Day, Norlestrin 21 1/50, Norlestrin 21 2.5/50, Norlestrin 28 1/50, Norlestrin Fe 1/50, Norlestrin Fe 2.5/50, Norlutate, Norlutin, Norminest Fe, Norquest Fe, Nortrel 0.5/35-21, Nortrel 0.5/35-28, Nortrel 1/35-21, Nortrel 1/35-28, Nortrel 7/7/7, Nylia 1/35, Nylia 7/7/7, Oriahnn (Copackaged), Ortho-Novum 1/35-21, Ortho-Novum 1/35-28, Ortho-Novum 1/50 21, Ortho-Novum 1/50 28, Ortho-Novum 1/80 21, Ortho-Novum 1/80 28, Ortho-Novum 2-21, Ortho-Novum 7/7/7-21, Ortho-Novum 7/7/7-28, Ortho-Novum 7/14-21, Ortho-Novum 7/14-28, Ortho-Novum 10-21, Ortho-Novum 10/11-21, Ortho-Novum 10/11-28, Ovcon-35, Ovcon-50, Philith, Pirmella 1/35, Pirmella 7/7/7, Taytulla, Tri-Legest 21, Tri-Legest 21, Tri-Legest Fe, Tri-Norinyl 21-Day, Tri-Norinyl 28-Day, Vyfemla, Wera)
• Ethinylestradiol and norgestimate (Estarylla, Mili, Mono-Linyah, Ortho Cyclen-21, Ortho Cyclen-28, Ortho Tri-Cyclen, Ortho Tri-Cyclen 21, Ortho Tri-Cyclen 28, Ortho Tri-Cyclen Lo, Previfem, Sprintec, Tri Lo Sprintec, Tri-Estarylla, Tri-Linyah, Tri-Lo-Estarylla, Tri-Lo-Linyah, Tri-Mili, Tri-Previfem, Tri-Sprintec)
• Ethinylestradiol and norgestrel (Cryselle, Elinest, Lo/Ovral, Lo/Ovral-28, Low-Ogestrel-21, Low-Ogestrel-28, Ogestrel 0.5/50-21, Ogestrel 0.5/50-28, Ovral, Ovral-28)
• Mestranol and norethisterone (Norinyl 1+50 28-Day)

Transdermal patches

See also: Contraceptive patch.

• Ethinylestradiol and norelgestromin (Ortho Evra, Xulane)

Vaginal rings

See also: Vaginal ring and Contraceptive vaginal ring.

• Ethinylestradiol and etonogestrel (NuvaRing)
• Ethinylestradiol and segesterone acetate (Annovera)

Combined injectable contraceptives

See also: Combined injectable contraceptive.

Estradiol cypionate and medroxyprogesterone acetate (Lunelle; 5 mg / 25 mg) was previously available in the U.S. but was discontinued.

Progestogen-only contraceptives

See also: Progestogen-only contraception.

Progestogen-only pills

See also: Progestogen-only pill.

• Drospirenone (Slynd) – 4 mg (available as of 2019)^[42]
• Norethisterone (Camila, Errin, Heather, Incassia, Jencycla, Micronor, Nor-QD) – 0.35 mg
• Norgestrel (Opill) – 0.075 mg (available over-the-counter as of 2023)^[43]

Norgestrel (Ovrette; 0.075 mg) was also previously available in the U.S. as a prescription, but was discontinued in 2005 due to "marketing reasons".^[44]

Postcoital emergency contraceptive pills

• Levonorgestrel (Athentia Next, Fallback Solo, Her Style, Opcicon One-Step, Plan B, Plan B One-Step) – 0.75 mg, 1.5 mg

Progestogen-only injectable contraceptives

See also: Progestogen-only injectable contraceptive.

• Medroxyprogesterone acetate (Depo-Provera) – 150 mg/mL (intramuscular)
• Medroxyprogesterone acetate (Depo-SubQ Provera 104) – 104 mg/0.65 mL (subcutaneous)

Intrauterine devices

See also: Intrauterine device, IUD with progestogen and Long-acting reversible contraception.

• Levonorgestrel (Kyleena, Liletta, Mirena, Skyla) – 13.5 mg/device, 19.5 mg/device, 52 mg/device

Progesterone (Progestasert; 38 mg/device) was previously available in the U.S. but was discontinued.

Subcutaneous implants

See also: Contraceptive implant, Etonogestrel contraceptive implant and Long-acting reversible contraception.

• Etonogestrel (Implanon, Nexplanon) – 68 mg/implant
• Levonorgestrel (Jadelle, Norplant, Norplant System in Plastic Container) – 36 mg/implant, 75 mg/implant

For other uses

See also: Hormone replacement therapy and Hormone replacement therapy (menopause).

Combined with estrogen

Oral pills

• Conjugated estrogens and medroxyprogesterone acetate (Premphase (Premarin, Cycrin 14/14), Premphase 14/14, Prempro, Prempro (Premarin, Cycrin), Prempro/Premphase) – 0.3 mg / 1.5 mg; 0.45 mg / 1.5 mg; 0.625 mg / 2.5 mg; 0.625 mg / 5 mg
• Estradiol and drospirenone (Angeliq) – 0.5 mg / 0.25 mg; 1 mg / 0.5 mg
• Estradiol and norethisterone acetate (Activella, Amabelz) – 1 mg / 0.5 mg; 0.5 mg / 0.1 mg
• Ethinylestradiol and norethisterone acetate (FemHRT) – 25 μg / 0.5 mg

Estradiol/progesterone (TX-001HR), a combination of estradiol and progesterone in oil-filled capsules, is currently pending approval.^[45]

Estradiol and norgestimate (Prefest; 1 mg / 90 μg) was previously available in the U.S. but was discontinued.

Transdermal patches

• Estradiol and levonorgestrel (Climara Pro) – 45 μg/24 hours / 15 μg/24 hours
• Estradiol and norethisterone acetate (Combipatch) – 50 μg/24 hours / 0.14 mg/24 hours; 50 μg/24 hours / 0.25 mg/24 hours

Progestogen-only

Oral pills

• Medroxyprogesterone acetate (Amen, Curretab, Cycrin, Provera) – 2.5 mg, 5 mg, 10 mg
• Megestrol acetate (Megace) – 20 mg, 40 mg – approved specifically for the treatment of breast and endometrial cancer^[46] and for the treatment of anorexia, cachexia, and weight loss in patients with ^[47]
• Norethisterone acetate (Aygestin, Norlutate) – 5 mg
• Progesterone (Prometrium) – 100 mg, 200 mg, 300 mg

Atypical:

• Danazol (Danocrine) – 50 mg, 100 mg, 200 mg – approved specifically for the treatment of endometriosis

Oral suspensions

• Megestrol acetate (Megace, Megace ES) – 40 mg/mL, 125 mg/mL – approved specifically for the treatment of anorexia, cachexia, and weight loss in patients with

Vaginal tablets

• Progesterone (Endometrin) – 100 mg

Vaginal gels

• Progesterone (Crinone) – 4%, 8%

Intramuscular injectables

• Hydroxyprogesterone caproate (Delalutin, Makena, Makena Preservative Free) – 125 mg/mL, 250 mg/mL
• Medroxyprogesterone acetate (Depo-Provera) – 400 mg/mL – approved specifically for the treatment of endometrial/renal cancer
• Progesterone (Progesterone) – 50 mg/mL (25 mg/mL discontinued)

Miscellaneous

• Norethisterone acetate and leuprorelin (Lupaneta Pack) – 5 mg norethisterone acetate oral pills, 3.75 mg/vial, 11.25 mg/vial leuprorelin for intramuscular injection – approved specifically for the treatment of painful endometriosis

Not available in the United States

• Acetomepregenol
• Algestone acetophenide
• Allylestrenol
• Chlormadinone acetate
• Cyproterone acetate
• Demegestone
• Dimethisterone
• Dydrogesterone
• Ethisterone
• Gestodene
• Gestonorone caproate
• Gestrinone
• Haloprogesterone
• Hydroxyprogesterone acetate
• Hydroxyprogesterone heptanoate
• Lynestrenol
• Medrogestone
• Nomegestrol acetate
• Norethisterone enanthate
• Noretynodrel
• Norgesterone
• Norgestrienone
• Normethandrone
• Norvinisterone
• Oxendolone
• Pentagestrone acetate
• Promegestone
• Quingestanol acetate
• Quingestrone
• Segesterone acetate
• Tibolone
• Trengestone
• Trimegestone

See also

• List of sex-hormonal medications available in the United States
• List of progestogens
• List of progestogen esters
• Oral contraceptive formulations
• Estradiol-containing oral contraceptive

Notes and References

1. Web site: Aurovela 1.5/30- norethindrone acetate and ethinyl estradiol tablet. DailyMed.
2. Web site: Aurovela 1/20- norethindrone acetate and ethinyl estradiol tablet. DailyMed.
3. Web site: Aurovela 24 FE- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit. DailyMed.
4. Web site: Aurovela Fe 1.5/30: FDA-Approved Drugs. U.S. Food and Drug Administration (FDA).
5. Web site: Aurovela FE 1/20- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit. DailyMed.
6. Web site: Aurovela FE- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit. DailyMed.
7. Web site: Blisovi 24 FE- norethindrone acetate and ethinyl estradiol kit. DailyMed.
8. Web site: Blisovi FE 1.5/30- norethindrone acetate and ethinyl estradiol kit. DailyMed.
9. Web site: Blisovi FE 1/20- norethindrone acetate and ethinyl estradiol kit. DailyMed.
10. Web site: Chabelina Fe: FDA-Approved Drugs. U.S. Food and Drug Administration (FDA).
11. Web site: Charlotte 24FE- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit. DailyMed.
12. Web site: Estrostep 21: FDA-Approved Drugs. U.S. Food and Drug Administration (FDA).
13. Web site: Estrostep FE- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit. DailyMed.
14. Web site: Femhrt- norethindrone acetate/ethinyl estradiol tablet. DailyMed.
15. Web site: Finzala: FDA-Approved Drugs. U.S. Food and Drug Administration (FDA).
16. Web site: Fyavolv- norethindrone acetate and ethinyl estradiol tablet, film coated. DailyMed.
17. Web site: Gemmily- norethindrone acetate and ethinyl estradiol, and ferrous fumarate kit. DailyMed.
18. Web site: Gildess 1.5/30 (norethindrone acetate and ethinyl estradiol tablets, USP). DailyMed.
19. Web site: Gildess 1/20 (norethindrone acetate and ethinyl estradiol tablets, USP). DailyMed.
20. Web site: Gildess 24 Fe (norethindrone acetate and ethinyl estradiol tablets, USP). DailyMed.
21. Web site: Gildess Fe 1.5/30 (norethindrone acetate and ethinyl estradiol tablets, USP). DailyMed.
22. Web site: Gildess Fe 1/20 (norethindrone acetate and ethinyl estradiol tablets, USP). DailyMed.
23. Web site: Hailey FE 1.5/30- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit. DailyMed.
24. Web site: Hailey 24 FE- norethindrone acetate and ethinyl estradiol, and ferrous fumarate kit. DailyMed.
25. Web site: Hailey FE 1/20- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit. DailyMed.
26. Web site: Jinteli- norethindrone acetate and ethinyl estradiol tablet. DailyMed.
27. Web site: Junel FE 1.5/30- norethindrone acetate and ethinyl estradiol, and ferrous fumarate kit. DailyMed.
28. Web site: Junel 21 DAY- norethindrone acetate and ethinyl estradiol tablet JUNEL FE 28 DAY- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit. DailyMed.
29. Web site: Junel FE 1/20- norethindrone acetate and ethinyl estradiol, and ferrous fumarate kit. DailyMed.
30. Web site: Junel FE 24- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit. DailyMed.
31. Web site: Larin 1.5/30- norethindrone acetate/ethinyl estradiol kit. DailyMed.
32. Web site: Larin 1/20- norethindrone acetate/ethinyl estradiol kit. DailyMed.
33. Web site: Larin 24 FE- norethindrone acetate/ethinyl estradiol and ferrous fumarate kit. DailyMed.
34. Web site: Larin FE 1.5/30- norethindrone acetate/ethinyl estradiol and ferrous fumarate kit. DailyMed.
35. Web site: Larin FE 1/20- norethindrone acetate/ethinyl estradiol and ferrous fumarate kit. DailyMed.
36. Web site: Lo Loestrin FE- norethindrone acetate and ethinyl estradiol, ethinyl estradiol and ferrous fumarate kit. DailyMed.
37. Web site: Loestrin 21 DAY- norethindrone acetate and ethinyl estradiol tablet Loestrin FE 28 DAY- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit. DailyMed.
38. Web site: Loestrin 24 FE- norethindrone acetate and ethinyl estradiol, and ferrous fumarate kit. DailyMed.
39. Web site: Lomedia 24 FE- norethindrone acetate and ethinyl estradiol kit. DailyMed.
40. Web site: Melodetta 24 FE- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit. DailyMed.
41. Web site: Merzee- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit. DailyMed.
42. Web site: Slynd, a Progestin-Only Contraceptive, Now Available . Brian Park, PharmD . 16 September 2019 . Monthly Prescribing Reference (MPR) . Haymarket Media, Inc. . 5 January 2020.
43. Web site: Commissioner . Office of the . 2023-07-13 . FDA Approves First Nonprescription Daily Oral Contraceptive . 2024-03-17 . FDA . en.
44. Web site: Murry . Karen . July 13, 2023 . Decisional Memorandum New Drug Application 17031 Supplement 41 Application for Full Prescription-to-Nonprescription Switch of Norgestrel Tablets 0.075 mg . FDA.
45. Pickar JH, Bon C, Amadio JM, Mirkin S, Bernick B . Pharmacokinetics of the first combination 17β-estradiol/progesterone capsule in clinical development for menopausal hormone therapy . Menopause . 22 . 12 . 1308–16 . 2015 . 25944519 . 4666011 . 10.1097/GME.0000000000000467 .
46. Book: Jame Abraham. James L. Gulley. Carmen J. Allegra. Bethesda Handbook of Clinical Oncology. 1 September 2009. Lippincott Williams & Wilkins. 978-0-7817-9558-6. 612–.
47. Book: Guido Eibl. Mouad Edderkaoui. Risk Factors for Pancreatic Cancer: Underlying Mechanisms and Potential Targets. 22 April 2015. Frontiers Media SA. 978-2-88919-468-1. 96–. In 1993, the Food and Drug Administration (FDA) approved megestrol acetate for the treatment of cancer anorexia-cachexia syndrome as well as cachexia due to chronic conditions, including human acquired immunodeficiency syndrome (AIDS)..