The following is a list of professional baseball teams based in Fort Wayne, Indiana. The list includes the league(s) the Fort Wayne teams were members of, and the number championships won.
| Team | League | Class | Affiliate | First Season | Last Season | History |
|---|---|---|---|---|---|---|
| Fort Wayne Hoosiers | Northwestern League | Independent | None | 1883 | 1884 | League was unclassified |
| Fort Wayne | Indiana State League | Independent | None | 1888 | 1890 | League was unclassified |
| Fort Wayne | Northwestern League | Independent | None | 1891 | 1891 | League was unclassified |
| Fort Wayne | Class A | None | 1892 | 1892 | St. Paul Saints relocated to Fort Wayne | |
| Fort Wayne | Western Interstate League | Class B | None | 1895 | 1895 | No nickname known. |
| Fort Wayne Farmers | Interstate League | Class C | None | 1896 | 1896 | Charter member of Interstate League |
| Fort Wayne Indians | Interstate League | Class B | None | 1897 | 1900 | 1900 League champions |
| Fort Wayne Railroaders | Western Association | Class A | None | 1901 | 1901 | League folded after 1901 season |
| Fort Wayne Railroaders | Central League | Class B | None | 1903 | 1905 | 1903 and 1905 league champions |
| Fort Wayne Railroaders | Interstate Association | Class C | None | 1906 | 1906 | League folded during season, League champions |
| Fort Wayne Billikens | Central League | Class B | None | 1908 | 1910 | Returned to Central League play |
| Fort Wayne Brakies | Central League | Class B | None | 1911 | 1911 | Continued Central League play with new nicknams |
| Fort Wayne Railroaders | Central League | Class B | None | 1912 | 1912 | League champions |
| Fort Wayne Champs | Central League | Class B | None | 1913 | 1913 | New nickname after winning championship in 1912 |
| Fort Wayne Railroaders | Central League | Class B | None | 1914 | 1914 | Continued Central League play |
| Fort Wayne Cubs | Central League | Class B | None | 1915 | 1915 | Continued Central League play. |
| Fort Wayne Chiefs | Central League | Class B | Cleveland Indians (1932) | 1917 1928 1932 1934 | 1917 1930 1932 1934 | League champions 1928, 1934 |
| Fort Wayne Chiefs | Illinois-Indiana-Iowa League | Class B | None | 1935 | 1935 | Replaced by Moline Plowboys in league play. |
| Fort Wayne Generals | Central League | Class A | 1948 | 1948 | Replaced by Charleston Senators in league play. | |
| Fort Wayne Daisies | All-American Girls Professional Baseball League | Women's | None | 1945 | 1954 | The Daisies played for the duration of the league. |
| Fort Wayne Wizards | Midwest League | Class A | Minnesota Twins (1993-1998) San Diego Padres (1999-2008) | 1993 | 2008 | Kenosha Twins relocated to Fort Wayne |
| Fort Wayne TinCaps | Midwest League | Class A | San Diego Padres (2009-2024) | 2009 | 2024 | 2009 league champions. |