| Post: | Prime Minister |
| Body: | the Papal States |
| Insignia: | CoA_Pontifical_States_02.svg |
| Insigniasize: | 120px |
| Style: | His Excellency |
| Appointer: | Pope Pius IX |
| Formation: | July 17, 1847 |
| First: | Cardinal Gabriele Ferretti |
| Last: | Cardinal Carlo Emanuele Muzzarelli |
| Abolished: | December 26, 1849 |
This is a list of the prime ministers of the Papal States. Officially, the prime minister was recognized as the Minister of the Interior (Italian: Ministro dell'Interno), as the title of "chief of the government" was reserved to the Cardinal Secretary of State. The office was created by the granting of the Statute of the Papal States in 1848 to 1850, when Pope Pius IX disclaimed the Statute after the Roman Republic's fall in 1849.
| width=70 colspan=2 | Portrait | Name | Took office | Left office | Political party | Pope |
|---|---|---|---|---|---|---|
| Cardinal Gabriele Ferretti | 17 July 1847 | 21 January 1848 | Clergy | Pius IX | ||
| Cardinal Giuseppe Bofondi | 21 January 1848 | 10 March 1848 | Clergy | |||
| Cardinal Giacomo Antonelli | 10 March 1848 | 4 May 1848 | Clergy | |||
| Count Terenzio Mamiani della Rovere | 4 May 1848 | 6 August 1848 | Moderate | |||
| Count Edoardo Fabbri | 6 August 1848 | 16 September 1848 | Moderate | |||
| Pellegrino Rossi | 16 September 1848 | 15 November 1848 | Moderate | |||
| Cardinal Carlo Emanuele Muzzarelli | 20 November 1848 | 25 April 1849 | Clergy |