List of oncogenic bacteria explained

This is a list of bacteria that have been identified as promoting or causing:

• Uncontrolled growth of tissue in the body
• Cancer
• Carcinomas
• Tumors (including benign or slow growing)
• Neoplasms
• Sarcomas
• Precancerous lesions
• Coinfectious agent promoting the above growths

Species or genera

Species or genera	Possibly associated cancers	Ref
Bacteroides fragilis	Colon cancer.	^[1]
Borrelia burgdorferi	MALT lymphoma.	^[2]
Campylobacter jejuni	Immunoproliferative small intestinal disease (IPSID), which is rare a type of MALT lymphoma.
Chlamydia pneumonia	Lung MALT lymphoma.
Chlamydia trachomatis (chlamydia)	Cervical cancer.
Chlamydophila psittaci	Ocular/adnexal lymphoma (forms of eye cancer).
Clostridium ssp	Colon cancer.
Cutibacterium acnes	Bladder and prostate cancer.
Fusobacterium nucleatum	Colorectal cancer	^[3]
Helicobacter bilis	Biliary cancers (such as gallbladder and biliary tract cancers).
Helicobacter bizzozeronii	Gastric MALT lymphoma.
Helicobacter felis	Gastric MALT lymphoma.
Helicobacter heilmannii	Marginal zone B-cell lymphoma of the stomach.	^[4]
Helicobacter hepaticus	Biliary cancer.
Helicobacter pylori	Stomach cancer, Marginal zone B-cell lymphoma of the stomach, and bile duct cancer	^[5] ^[6]
Helicobacter salomonis	Gastric MALT lymphoma.
Helicobacter suis	Gastric MALT lymphoma.
Mycoplasma spp	Stomach, colon, ovarian, and lung cancers (particularly M. fermentans, M. penetrans, M. hyorhinis).
Neisseria gonorrhoeae (gonorrhea)	Bladder cancer and possibly prostate cancer.
Salmonella enterica serovar Paratyphi	Biliary cancer.	^[7] ^[8]
Salmonella enterica serovar Typhimurium	Biliary cancer.	^[9]
Streptococcus bovis	Colorectal cancer	^[10]
Treponema pallidum (syphilis)	Bladder cancer and possibly prostate cancer.

See also

• Carcinogenic bacteria
• Sexually transmitted disease
• Infectious causes of cancer
• Infections associated with diseases
• List of infectious diseases
• Timeline of peptic ulcer disease and Helicobacter pylori - featured list

Further reading

• Cornwall, Claudia. Catching cancer : the quest for its viral and bacterial causes. Rowman & Littlefield Publishers (2013) Lanham, Maryland. .

Notes and References

1. Sinkovics. Joseph. Molecular biology of oncogenic inflammatory processes. I. Non-oncogenic and oncogenic pathogens, intrinsic inflammatory reactions without pathogens, and microRNA/DNA interactions (Review). International Journal of Oncology. 2011. 1019-6439. 10.3892/ijo.2011.1248. 22076306. 40. 2. 305–49. free.
2. Chang. A. H.. Parsonnet. J.. Julie Parsonnet. Role of Bacteria in Oncogenesis. Clinical Microbiology Reviews. 23. 4. 2010. 837–857. 0893-8512. 10.1128/CMR.00012-10. 20930075. 2952975.
3. Kostic . Aleksandar D. . Chun . Eunyoung . Robertson . Lauren . Glickman . Jonathan N. . Gallini . Carey Ann . Michaud . Monia . Clancy . Thomas E. . Chung . Daniel C. . Lochhead . Paul . Hold . Georgina L. . El-Omar . Emad M. . Brenner . Dean . Fuchs . Charles S. . Meyerson . Matthew . Garrett . Wendy S. . Wendy Garrett . 2013-08-14 . Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor immune microenvironment . Cell Host & Microbe . 14 . 2 . 207–215 . 10.1016/j.chom.2013.07.007 . 1931-3128 . 3772512 . 23954159.
4. Schreuder MI, van den Brand M, Hebeda KM, Groenen PJ, van Krieken JH, Scheijen B . Novel developments in the pathogenesis and diagnosis of extranodal marginal zone lymphoma . Journal of Hematopathology . 10 . 3–4 . 91–107 . December 2017 . 29225710 . 5712330 . 10.1007/s12308-017-0302-2 .
5. 2021-03-01. Molecular modelling of the gastric barrier response, from infection to carcinogenesis. Best Practice & Research Clinical Gastroenterology. en. 50-51. 101737. 10.1016/j.bpg.2021.101737. 1521-6918. Traulsen. Jan. Zagami. Claudia. Daddi. Alice Anna. Boccellato. Francesco. 33975688. 233900318 .
6. Bravo D, Hoare A, Soto C, Valenzuela MA, Quest AF . Helicobacter pylori in human health and disease: Mechanisms for local gastric and systemic effects . World Journal of Gastroenterology . 24 . 28 . 3071–3089 . July 2018 . 30065554 . 6064966 . 10.3748/wjg.v24.i28.3071 . free .
7. Sepe. Ludovico P.. Hartl. Kimberly. Iftekhar. Amina. Berger. Hilmar. Kumar. Naveen. Goosmann. Christian. Chopra. Sascha. Schmidt. Sven Christian. Gurumurthy. Rajendra Kumar. Meyer. Thomas F.. Boccellato. Francesco. 2020-09-22. McClane. Bruce A.. Genotoxic Effect of Salmonella Paratyphi A Infection on Human Primary Gallbladder Cells. mBio. en. 11. 5. e01911–20, /mbio/11/5/mBio.01911–20.atom. 10.1128/mBio.01911-20. 2150-7511. 7512552. 32963006.
8. Boccellato. Francesco. Meyer. Thomas F.. June 2015. Bacteria Moving into Focus of Human Cancer. Cell Host & Microbe. 17. 6. 728–730. 10.1016/j.chom.2015.05.016. 26067598. 1931-3128. free.
9. Scanu. Tiziana. Spaapen. Robbert M.. Bakker. Jeroen M.. Pratap. Chandra Bhan. Wu. Lin-en. Hofland. Ingrid. Broeks. Annegien. Shukla. Vijay Kumar. Kumar. Mohan. Janssen. Hans. Song. Ji-Ying. June 2015. Salmonella Manipulation of Host Signaling Pathways Provokes Cellular Transformation Associated with Gallbladder Carcinoma. Cell Host & Microbe. en. 17. 6. 763–774. 10.1016/j.chom.2015.05.002. 26028364. free.
10. Klein . Robert S. . Recco . Rose A. . Catalano . Michela T. . Edberg . Stephen C. . Casey . Joan I. . Steigbigel . Neal H. . 1977-10-13 . Association of Streptococcus bovis with Carcinoma of the Colon . New England Journal of Medicine . en . 297 . 15 . 800–802 . 10.1056/NEJM197710132971503 . 408687 . 0028-4793.