This lists the singles that reached number one on the Spanish PROMUSICAE sales and airplay charts in 2022. Total sales correspond to the data sent by regular contributors to sales volumes and by digital distributors.
| Week | Issue date | Top Streaming, Downloads & Physical Sales | Most Airplay | ||||
|---|---|---|---|---|---|---|---|
| Artist(s) | Song | Ref. | Artist(s) | Song | Ref. | ||
| 1 | December 31 | Morad | "Pelele" | [1] | Adele | "Easy on Me" | [2] |
| 2 | January 7 | Rauw Alejandro and Chencho Corleone | "Desesperados" | [3] | Sebastián Yatra | "Tacones Rojos" | [4] |
| 3 | January 14 | [5] | [6] | ||||
| 4 | January 21 | [7] | [8] | ||||
| 5 | January 28 | Rigoberta Bandini | "Ay mamá" | [9] | [10] | ||
| 6 | February 4 | La Pantera, Quevedo, Juseph, Cruz Cafuné and Abhir Hathi | "Cayó La Nochee (Remix)" | [11] | [12] | ||
| 7 | February 11 | [13] | [14] | ||||
| 8 | February 18 | Becky G and Karol G | "Mamiii" | [15] | [16] | ||
| 9 | February 25 | La Pantera, Quevedo, Juseph, Cruz Cafuné and Abhir Hathi | "Cayó La Nochee (Remix)" | [17] | [18] | ||
| 10 | March 4 | [19] | [20] | ||||
| 11 | March 11 | [21] | [22] | ||||
| 12 | March 18 | Rosalía | "Candy" | [23] | Ana Mena | "Música Ligera" | [24] |
| 13 | March 25 | Paulo Londra | "Plan A" | [25] | [26] | ||
| 14 | April 2 | Alejo, Feid and ROBI | "Pantysito" | [27] | Sebastián Yatra | "Tacones Rojos" | [28] |
| 15 | April 9 | [29] | Ana Mena | "Música Ligera" | [30] | ||
| 16 | April 16 | [31] | [32] | ||||
| 17 | April 23 | Paulo Londra and Bizarrap | "Music Sessions Vol. 23" | [33] | [34] | ||
| 18 | April 30 | [35] | Aitana and Nicki Nicole | "Formentera" | [36] | ||
| 19 | May 6 | Bad Bunny | "Moscow Mule" | [37] | Sebastián Yatra | "Tacones Rojos" | [38] |
| 20 | May 13 | Chanel | "SloMo" | [39] | Camila Cabello featuring Ed Sheeran | "Bam Bam" | [40] |
| 21 | May 20 | Bad Bunny | "Tití Me Preguntó" | [41] | Sebastián Yatra | "Tacones Rojos" | [42] |
| 22 | May 27 | [43] | Harry Styles | "As It Was" | [44] | ||
| 23 | June 3 | [45] | [46] | ||||
| 24 | June 10 | [47] | Camila Cabello featuring Ed Sheeran | "Bam Bam" | [48] | ||
| 25 | June 17 | [49] | [50] | ||||
| 26 | June 24 | [51] | Shakira and Rauw Alejandro | "Te Felicito" | [52] | ||
| 27 | July 1 | [53] | Harry Styles | "As It Was" | [54] | ||
| 28 | July 8 | Bizarrap and Quevedo | "" | [55] | Dani Fernández | "Dile a los demás" | [56] |
| 29 | July 15 | [57] | Shakira and Rauw Alejandro | "Te Felicito" | [58] | ||
| 30 | July 22 | [59] | Harry Styles | "As It Was" | [60] | ||
| 31 | July 29 | Rosalía | "Despechá" | [61] | Shakira and Rauw Alejandro | "Te Felicito" | [62] |
| 32 | August 5 | Bizarrap and Quevedo | "Quevedo: Bzrp Music Sessions, Vol. 52" | [63] | Camila Cabello featuring Ed Sheeran | "Bam Bam" | [64] |
| 33 | August 12 | Rosalía | "Despechá" | [65] | Shakira and Rauw Alejandro | "Te Felicito" | [66] |
| 34 | August 19 | Bizarrap and Quevedo | "Quevedo: Bzrp Music Sessions, Vol. 52" | [67] | Camila Cabello featuring Ed Sheeran | "Bam Bam" | [68] |
| 35 | August 26 | [69] | Harry Styles | "As It Was" | [70] | ||
| 36 | September 2 | [71] | Camila Cabello featuring Ed Sheeran | "Bam Bam" | [72] | ||
| 37 | September 9 | [73] | [74] | ||||
| 38 | September 16 | [75] | Rosalía | "Despechá" | [76] | ||
| 39 | September 23 | [77] | [78] | ||||
| 40 | September 30 | [79] | Sangiovanni and Aitiana | "Mariposas" | [80] | ||
| 41 | October 7 | [81] | [82] | ||||
| 42 | October 14 | [83] | Rosalía | "Despechá" | [84] | ||
| 43 | October 21 | Manuel Turizo | "La Bachata" | [85] | [86] | ||
| 44 | October 28 | [87] | Sangiovanni and Aitiana | "Mariposas" | [88] | ||
| 45 | November 4 | Mora and Quevedo | "Apa" | [89] | [90] | ||
| 46 | November 11 | Manuel Turizo | "La Bachata" | [91] | [92] | ||
| 47 | November 18 | Bizarrap and Duki | "" | [93] | David Guetta and Bebe Rexha | "I'm Good (Blue)" | [94] |
| 48 | November 25 | Manuel Turizo | "La Bachata" | [95] | Sangiovanni and Aitiana | "Mariposas" | [96] |
| 49 | December 2 | Arcángel and Bad Bunny | "La Jumpa" | [97] | Manuel Turizo | "La Bachata" | [98] |
| 50 | December 9 | [99] | [100] | ||||
| 51 | December 16 | Quevedo and Myke Towers | "Playa del Inglés" | [101] | [102] | ||
| 52 | December 23 | Arcángel and Bad Bunny | "La Jumpa" | [103] | [104] | ||