This lists the singles that reached number one on the Spanish PROMUSICAE sales and airplay charts in 2021. Total sales correspond to the data sent by regular contributors to sales volumes and by digital distributors.
| Week | Issue date | Top Streaming, Downloads & Physical Sales | Most Airplay | ||||
|---|---|---|---|---|---|---|---|
| Artist(s) | Song | Ref. | Artist(s) | Song | Ref. | ||
| 1 | January 1 | Bad Bunny and Jhay Cortez | "Dakiti" | [1] | BTS | "Dynamite" | [2] |
| 2 | January 8 | [3] | Nil Moliner | "Mi Religión" | [4] | ||
| 3 | January 15 | Myke Towers and Juhn | "Bandido" | [5] | Dani Martín | "Portales" | [6] |
| 4 | January 22 | [7] | Ana Mena and Rocco Hunt | "A un Paso de la luna" | [8] | ||
| 5 | January 29 | [9] | Nil Moliner | "Mi Religión" | [10] | ||
| 6 | February 5 | [11] | [12] | ||||
| 7 | February 12 | Rochy RD, Myke Towers and Nicki Nicole | "Ella No Es Tuya" | [13] | Camilo | "Vida De Rico" | [14] |
| 8 | February 19 | [15] | Nil Moliner | "Mi Religión" | [16] | ||
| 9 | February 26 | C. Tangana featuring Gipsy Kings | "Ingobernable" | [17] | Ana Mena and Rocco Hunt | "A un Paso de la luna" | [18] |
| 10 | March 5 | Rochy RD, Myke Towers and Nicki Nicole | "Ella No es Tuya" | [19] | Camilo | "Vida De Rico" | [20] |
| 11 | March 12 | [21] | Purple Disco Machine and Sophie and the Giants | "Hypnotized" | [22] | ||
| 12 | March 19 | [23] | [24] | ||||
| 13 | March 26 | [25] | Álvaro de Luna | "Juramento eterno de sal" | [26] | ||
| 14 | April 2 | Los Legendarios, Wisin and Jhay Cortez | "Fiel" | [27] | Beret and Melendi | "Desde Cero" | [28] |
| 15 | April 9 | [29] | Purple Disco Machine and Sophie and the Giants | "Hypnotized" | [30] | ||
| 16 | April 16 | [31] | Álvaro de Luna | "Juramento eterno de sal" | [32] | ||
| 17 | April 23 | Sebastián Yatra featuring Myke Towers | "Pareja del Año" | [33] | Purple Disco Machine and Sophie and the Giants | "Hypnotized" | [34] |
| 18 | April 30 | [35] | Álvaro de Luna | "Juramento eterno de sal" | [36] | ||
| 19 | May 7 | [37] | [38] | ||||
| 20 | May 14 | [39] | [40] | ||||
| 21 | May 21 | Rauw Alejandro | "Todo de Ti" | [41] | [42] | ||
| 22 | May 28 | [43] | [44] | ||||
| 23 | June 5 | [45] | [46] | ||||
| 24 | June 12 | [47] | [48] | ||||
| 25 | June 19 | [49] | [50] | ||||
| 26 | June 26 | [51] | Purple Disco Machine and Sophie and the Giants | "Hypnotized" | [52] | ||
| 27 | July 3 | [53] | Rauw Alejandro | "Todo de Ti" | [54] | ||
| 28 | July 10 | [55] | Álvaro de Luna | "Juramento eterno de sal" | [56] | ||
| 29 | July 17 | [57] | [58] | ||||
| 30 | July 24 | Farruko | "Pepas" | [59] | Rauw Alejandro | "Todo de Ti" | [60] |
| 31 | July 31 | [61] | [62] | ||||
| 32 | August 7 | [63] | [64] | ||||
| 33 | August 14 | [65] | [66] | ||||
| 34 | August 21 | [67] | [68] | ||||
| 35 | August 28 | Zzoilo and Aitana | "Mon Amour (Remix)" | [69] | [70] | ||
| 36 | September 4 | [71] | [72] | ||||
| 37 | September 11 | [73] | [74] | ||||
| 38 | September 18 | [75] | [76] | ||||
| 39 | September 25 | [77] | [78] | ||||
| 40 | October 2 | [79] | Måneskin | "Beggin'" | [80] | ||
| 41 | October 9 | C. Tangana and Nathy Peluso | "Ateo" | [81] | Zzoilo and Aitana | "Mon Amour (Remix)" | [82] |
| 42 | October 16 | [83] | Nil Moliner | "Libertad" | [84] | ||
| 43 | October 23 | [85] | [86] | ||||
| 44 | October 30 | [87] | [88] | ||||
| 45 | November 6 | [89] | [90] | ||||
| 46 | November 13 | Rosalía featuring The Weeknd | "La Fama" | [91] | Zzoilo and Aitana | "Mon Amour (Remix)" | [92] |
| 47 | November 20 | [93] | The Kid Laroi and Justin Bieber | "Stay" | [94] | ||
| 48 | November 27 | [95] | Adele | "Easy on Me" | [96] | ||
| 49 | December 3 | Zzoilo and Aitana | "Mon Amour (Remix)" | [97] | Elton John and Dua Lipa | "Cold Heart" | [98] |
| 50 | December 10 | Bizarrap and Morad | "Morad: Bzrp Music Sessions, Vol. 47" | [99] | Adele | "Easy on Me" | [100] |
| 51 | December 17 | [101] | [102] | ||||
| 52 | December 24 | Zzoilo and Aitana | "Mon Amour (Remix)" | [103] | [104] | ||
| 1 | December 31 | Morad | "Pelele" | [105] | [106] | ||