This lists the singles that reached number one on the Spanish PROMUSICAE sales and airplay charts in 2019. Total sales correspond to the data sent by regular contributors to sales volumes and by digital distributors.
| Week | Issue date | Top Streaming, Downloads & Physical Sales | Most Airplay | |||||
|---|---|---|---|---|---|---|---|---|
| Artist(s) | Song | Ref. | Artist(s) | Song | Ref. | |||
| 1 | January 3 | Paulo Londra | "Adán y Eva" | [1] | Maroon 5< | -- Cardi B is not credited --> | "Girls Like You" | [2] |
| 2 | January 10 | [3] | [4] | |||||
| 3 | January 17 | [5] | Beret | "Lo siento" | [6] | |||
| 4 | January 24 | Anuel AA and Karol G | "Secreto" | [7] | [8] | |||
| 5 | January 31 | [9] | Lukas Graham | "Love Someone" | [10] | |||
| 6 | February 7 | [11] | [12] | |||||
| 7 | February 14 | Daddy Yankee featuring Snow | "Con Calma" | [13] | [14] | |||
| 8 | February 21 | [15] | David Guetta, Bebe Rexha and J Balvin | "Say My Name" | [16] | |||
| 9 | February 28 | [17] | Lukas Graham | "Love Someone" | [18] | |||
| 10 | March 7 | [19] | Ava Max | "Sweet but Psycho" | [20] | |||
| 11 | March 14 | Don Patricio and Cruz Cafuné | "Contando lunares" | [21] | Lukas Graham | "Love Someone" | [22] | |
| 12 | March 21 | [23] | [24] | |||||
| 13 | March 28 | [25] | Ava Max | "Sweet but Psycho" | [26] | |||
| 14 | April 4 | Rosalía, J Balvin and El Guincho | "Con altura" | [27] | Lukas Graham | "Love Someone" | [28] | |
| 15 | April 11 | [29] | Ava Max | "Sweet but Psycho" | [30] | |||
| 16 | April 18 | [31] | Lukas Graham | "Love Someone" | [32] | |||
| 17 | April 25 | [33] | [34] | |||||
| 18 | May 2 | [35] | [36] | |||||
| 19 | May 9 | [37] | Mark Ronson featuring Miley Cyrus | "Nothing Breaks Like a Heart" | [38] | |||
| 20 | May 16 | Lunay, Daddy Yankee and Bad Bunny | "Soltera" (Remix) | [39] | Ava Max | "Sweet but Psycho" | [40] | |
| 21 | May 23 | [41] | Lukas Graham | "Love Someone" | [42] | |||
| 22 | May 30 | Sech and Darell | "Otro Trago" | [43] | Ed Sheeran and Justin Bieber | "I Don't Care" | [44] | |
| 23 | June 6 | Rosalía | "Aute Cuture" | [45] | [46] | |||
| 24 | June 13 | Bad Bunny and Tainy | "Callaíta" | [47] | Lukas Graham | "Love Someone" | [48] | |
| 25 | June 20 | [49] | Alejandro Sanz and Camila Cabello | "Mi Persona Favorita" | [50] | |||
| 26 | June 27 | [51] | Jonas Brothers | "Sucker" | [52] | |||
| 27 | July 4 | [53] | Morat and Aitana | "Presiento" | [54] | |||
| 28 | July 11 | Rosalía | "Milionària" | [55] | [56] | |||
| 29 | July 18 | Bad Bunny and Tainy | "Callaíta" | [57] | Dvicio and Taburete | "5 Sentidos" | [58] | |
| 30 | July 25 | Anuel AA, Daddy Yankee and Karol G featuring J Balvin and Ozuna | "China" | [59] | Ed Sheeran and Justin Bieber | "I Don't Care" | [60] | |
| 31 | August 1 | [61] | Manuel Carrasco | "Qué Bonito Es Querer" | [62] | |||
| 32 | August 8 | [63] | Lewis Capaldi | "Someone You Loved" | [64] | |||
| 33 | August 15 | [65] | Panic! at the Disco | "High Hopes" | [66] | |||
| 34 | August 22 | [67] | Morat and Aitana | "Presiento" | [68] | |||
| 35 | August 29 | Rosalía and Ozuna | "Yo x Ti, Tú x Mí" | [69] | Ed Sheeran and Justin Bieber | "I Don't Care" | [70] | |
| 36 | September 5 | [71] | Shawn Mendes and Camila Cabello | "Señorita" | [72] | |||
| 37 | September 12 | [73] | [74] | |||||
| 38 | September 19 | [75] | [76] | |||||
| 39 | September 26 | [77] | [78] | |||||
| 40 | October 3 | Anuel AA, Daddy Yankee and Karol G featuring J Balvin and Ozuna | "China" | [79] | [80] | |||
| 41 | October 10 | [81] | Manuel Carrasco | "Qué Bonito Es Querer" | [82] | |||
| 42 | October 17 | [83] | Lewis Capaldi | "Someone You Loved" | [84] | |||
| 43 | October 24 | [85] | Shawn Mendes and Camila Cabello | "Señorita" | [86] | |||
| 44 | October 31 | Omar Montes and Bad Gyal | "Alocao" | [87] | [88] | |||
| 45 | November 7 | [89] | Manuel Carrasco | "Qué Bonito Es Querer" | [90] | |||
| 46 | November 14 | [91] | [92] | |||||
| 47 | November 21 | [93] | [94] | |||||
| 48 | November 28 | [95] | Tones and I | "Dance Monkey" | [96] | |||
| 49 | December 5 | Karol G and Nicki Minaj | "Tusa" | [97] | [98] | |||
| 50 | December 12 | [99] | Sinsinati | "Indios y vaqueros" | [100] | |||
| 51 | December 19 | [101] | Morat | "A dónde vamos" | [102] | |||
| 52 | December 26 | [103] | Dani Fernández | "Disparos" | [104] | |||