This is a list of the Irish Recorded Music Association's Irish Singles Chart Top 50 number-ones of 2008.
| Issue Date | Song | Artist |
|---|---|---|
| 3 January | "When You Believe" | Leon Jackson |
| 10 January | "Piece of Me" | Britney Spears |
| 17 January | ||
| 24 January | "Now You're Gone" | Basshunter |
| 31 January | ||
| 7 February | ||
| 14 February | ||
| 21 February | ||
| 28 February | "Mercy" | Duffy |
| 6 March | "The Ballad of Ronnie Drew" | U2, The Dubliners, Kíla and A Band of Bowsies |
| 13 March | ||
| 20 March | "Mercy" | Duffy |
| 27 March | "Low" | Flo Rida featuring T-Pain |
| 3 April | "The Munster Song" | Glen Keating and Greg Ryan |
| 10 April | "The Galway Girl" | Sharon Shannon & Mundy |
| 17 April | ||
| 24 April | ||
| 1 May | ||
| 8 May | ||
| 15 May | "4 Minutes" | Madonna featuring Justin Timberlake and Timbaland |
| 22 May | "Take A Bow" | Rihanna |
| 29 May | ||
| 5 June | ||
| 12 June | ||
| 19 June | "Forever" | Chris Brown |
| 26 June | "On Wings" | Leanne Moore |
| 3 July | "Forever" | Chris Brown |
| 10 July | "All I Ever Wanted" | Basshunter |
| 17 July | ||
| 24 July | "All Summer Long" | Kid Rock |
| 31 July | ||
| 7 August | ||
| 14 August | ||
| 21 August | "I Kissed a Girl" | Katy Perry |
| 28 August | ||
| 4 September | ||
| 11 September | ||
| 18 September | "Sex on Fire" | Kings of Leon |
| 25 September | ||
| 2 October | "So What" | |
| 9 October | ||
| 16 October | "About You Now" | The Saw Doctors |
| 23 October | "So What" | Pink |
| 30 October | "Hero" | The X Factor Finalists 2008 |
| 6 November | ||
| 13 November | ||
| 20 November | "Run" | Leona Lewis |
| 27 November | ||
| 4 December | ||
| 11 December | ||
| 18 December | "Hallelujah" | Alexandra Burke |
| 25 December |