This is a list of singles which have reached number one on the Irish Singles Chart in 1988.
| Week ending | Song | Artist | Ref. |
|---|---|---|---|
| 2 January | "Fairytale of New York" | The Pogues featuring Kirsty MacColl | |
| 9 January | |||
| 16 January | "Heaven is a Place on Earth" | Belinda Carlisle | |
| 23 January | "Sign Your Name" | Terence Trent D'Arby | |
| 30 January | "I Think We're Alone Now" | Tiffany | |
| 6 February | |||
| 13 February | "When Will I Be Famous" | Bros | |
| 20 February | "Get Outta My Dreams, Get into My Car" | Billy Ocean | |
| 27 February | "I Should Be So Lucky" | Kylie Minogue | |
| 5 March | |||
| 12 March | "Together Forever" | Rick Astley | |
| 19 March | "Feet on the Ground" | Hothouse Flowers | |
| 26 March | "Drop the Boy" | Bros | |
| 2 April | "Could've Been" | Tiffany | |
| 9 April | "Heart" | Pet Shop Boys | |
| 16 April | |||
| 23 April | |||
| 30 April | "One More Try" | ||
| 7 May | "Perfect" | ||
| 14 May | |||
| 21 May | "With a Little Help from My Friends" | ||
| 28 May | |||
| 4 June | |||
| 11 June | "The Boys in Green" | Republic of Ireland Soccer Squad | |
| 18 June | |||
| 25 June | |||
| 2 July | |||
| 9 July | "Fast Car" | Tracy Chapman | |
| 16 July | "Nothing's Gonna Change My Love for You" | Glenn Medeiros | |
| 23 July | |||
| 30 July | [1] | ||
| 6 August | "Flight of Earls" | Paddy Reilly | |
| 13 August | "The Locomotion" | Kylie Minogue | |
| 20 August | "The Only Way Is Up" | Yazz and the Plastic Population | |
| 27 August | |||
| 3 September | "The Harder I Try" | Brother Beyond | |
| 10 September | "A Groovy Kind of Love" | Phil Collins | |
| 17 September | |||
| 24 September | "Desire" | U2 | |
| 1 October | |||
| 8 October | [2] | ||
| 15 October | |||
| 22 October | "Orinoco Flow (Sail Away)" | Enya | |
| 29 October | |||
| 5 November | |||
| 12 November | |||
| 19 November | "Stand Up for Your Love Rights" | Yazz and the Plastic Population | |
| 26 November | "First Time" | ||
| 3 December | "Missing You" | Chris de Burgh | |
| 10 December | "Mistletoe and Wine" | Cliff Richard | |
| 17 December | |||
| 24 December | |||
| 31 December |