This is a list of the number-one hits of 2010 on FIMI's Italian Singles and Albums Charts.
| Issue date | Song | Artist | Album | Artist | |
|---|---|---|---|---|---|
| 4 January | "Bad Romance" | Lady Gaga | Tracks 2 (inediti & rarità) | Vasco Rossi | |
| 11 January | "Baciami ancora" | Jovanotti | |||
| 18 January | |||||
| 25 January | |||||
| 1 February | Soldier of Love | Sade | |||
| 8 February | |||||
| 15 February | "Per tutta la vita" | Noemi | Re matto | Marco Mengoni | |
| 22 February | "Per tutte le volte che..." | Valerio Scanu | |||
| 1 March | "Baciami ancora" | Jovanotti | |||
| 8 March | "Per tutta la vita" | Noemi | |||
| 15 March | "Each Tear" | Mary J. Blige featuring Tiziano Ferro | Oltre | Emma Marrone | |
| 22 March | "Di notte" | Pierdavide Carone | |||
| 29 March | "Calore" | Emma Marrone | Una canzone pop | Pierdavide Carone | |
| 5 April | |||||
| 12 April | "Un colpo all'anima" | Ligabue | Inaspettata | Biagio Antonacci | |
| 19 April | |||||
| 26 April | |||||
| 3 May | "Alors on danse" | Stromae | |||
| 10 May | "Quello che dai" | Marco Carta | Arrivederci, mostro! | Ligabue | |
| 17 May | "Waka Waka (This Time for Africa)" | Shakira featuring Freshlyground | |||
| 24 May | |||||
| 31 May | |||||
| 7 June | Semplicemente sei | Gigi D'Alessio | |||
| 14 June | Arrivederci, mostro | Ligabue | |||
| 21 June | Vasco London Instant Live 04.05.2010 | Vasco Rossi | |||
| 28 June | |||||
| 5 July | |||||
| 12 July | Arrivederci, mostro | Ligabue | |||
| 19 July | |||||
| 26 July | |||||
| 2 August | She Wolf | Shakira | |||
| 9 August | |||||
| 16 August | The Final Frontier | Iron Maiden | |||
| 23 August | |||||
| 30 August | |||||
| 6 September | "Love the Way You Lie" | Eminem featuring Rihanna | Controcultura | Fabri Fibra | |
| 13 September | "White Knuckle Ride" | Jamiroquai | A Thousand Suns | Linkin Park | |
| 20 September | "Love the Way You Lie" | Eminem featuring Rihanna | Wonderlustre | Skunk Anansie | |
| 27 September | "Loca" | Shakira featuring Dizzee Rascal | Il mondo in un secondo | Alessandra Amoroso | |
| 4 October | |||||
| 11 October | |||||
| 18 October | Re matto live | Marco Mengoni | |||
| 25 October | Sale el Sol | Shakira | |||
| 1 November | Chocabeck | Zucchero | |||
| 8 November | "Only Girl (In the World)" | Rihanna | |||
| 15 November | "The Time (Dirty Bit)" | The Black Eyed Peas | Casa 69 | Negramaro | |
| 22 November | "In punta di piedi" | Nathalie | |||
| 29 November | "Tutto l'amore che ho" | Jovanotti | Arrivederci, mostro | Ligabue | |
| 6 December | Michael | Michael Jackson | |||
| 13 December | |||||
| 20 December | Chocabeck | Zucchero | |||
| 27 December | Michael | Michael Jackson |