This is a list of the German Media Control Top100 Singles Chart number-ones of 1988.
| Indicates best-performing single and album of 1988[1] [2] |
| Song | Artist | Album | Artist | |
| 4 January | "Whenever You Need Somebody" | "Misteriosa Venezia" | Rondò Veneziano | |
| 11 January | "Always on My Mind" | Pet Shop Boys | ||
| 18 January | "Whenever You Need Somebody" | Rick Astley | ||
| 25 January | ||||
| 1 February | bgcolor=#FFFF99 rowspan="3" | "Dirty Dancing" | Various artists | |
| 8 February | ||||
| 15 February | ||||
| 22 February | "My Love Is a Tango" | Guillermo Marchena | "Lange Schatten" | Peter Maffay |
| 29 February | ||||
| 7 March | "Tell It to My Heart" | Taylor Dayne | ||
| 14 March | bgcolor=#FFFF99 rowspan="4" | "Dirty Dancing" | Various artists | |
| 21 March | ||||
| 28 March | ||||
| 4 April | ||||
| 11 April | "I Should Be So Lucky" | "More Dirty Dancing" | ||
| 18 April | "Ö" | Herbert Grönemeyer | ||
| 25 April | "Heart" | Pet Shop Boys | ||
| 2 May | ||||
| 9 May | ||||
| 16 May | ||||
| 23 May | "Ella, Elle L'a" | France Gall | ||
| 30 May | ||||
| 6 June | ||||
| 13 June | ||||
| 20 June | "Im Nin'Alu" | Ofra Haza | ||
| 27 June | ||||
| 4 July | ||||
| 11 July | ||||
| 18 July | ||||
| 25 July | "Bad" | Michael Jackson | ||
| 1 August | ||||
| 8 August | ||||
| 15 August | "The Twist" | The Fat Boys & Chubby Checker | ||
| 22 August | bgcolor=#FFFF99 rowspan="6" | "Girl You Know It's True" | Milli Vanilli | |
| 29 August | "Tracy Chapman" | Tracy Chapman | ||
| 5 September | ||||
| 12 September | ||||
| 19 September | "Da Capo" | BAP | ||
| 26 September | ||||
| 3 October | "Hand in Hand" | Koreana | ||
| 10 October | ||||
| 17 October | ||||
| 24 October | "One Moment in Time" | "Rattle and Hum" | U2 | |
| 31 October | ||||
| 7 November | "Don't Worry, Be Happy" | Bobby McFerrin | ||
| 14 November | ||||
| 21 November | ||||
| 28 November | "Live - Nach uns die Sintflut" | Die Ärzte | ||
| 5 December | "Rattle and Hum" | U2 | ||
| 12 December | "Pop Goes Classic" | Munich Symphony Orchestra | ||
| 19 December | ||||
| 26 December |