This is a list of the German Media Control Top100 Singles Chart number-ones of 1980.
| Indicates best-performing single and album of 1980[1] [2] |
| 7 January | "Maybe" | "Weihnachten mit Andrea Jürgens" | Andrea Jürgens | |||
| 14 January | ||||||
| 21 January | bgcolor=#FFFF99 rowspan="2" | "Sun of Jamaica" | bgcolor=#FFFF99 rowspan="17" | "The Wall" | Pink Floyd | |
| 28 January | ||||||
| 4 February | "Another Brick in the Wall Part II" | Pink Floyd | ||||
| 11 February | ||||||
| 18 February | ||||||
| 25 February | bgcolor=#FFFF99 | "Sun of Jamaica" | Goombay Dance Band | |||
| 3 March | "Another Brick in the Wall Part II" | Pink Floyd | ||||
| 10 March | bgcolor=#FFFF99 rowspan="5" | "Sun of Jamaica" | Goombay Dance Band | |||
| 17 March | ||||||
| 24 March | ||||||
| 31 March | ||||||
| 7 April | ||||||
| 14 April | "It's a Real Good Feeling" | Peter Kent | ||||
| 21 April | bgcolor=#FFFF99 | "Sun of Jamaica" | Goombay Dance Band | |||
| 28 April | "Weekend" | Earth & Fire | ||||
| 5 May | ||||||
| 12 May | ||||||
| 19 May | "Die schonsten Melodien der Welt" | Orchester Anthony Ventura | ||||
| 26 May | "Der Nippel" | Mike Krüger | ||||
| 2 June | ||||||
| 9 June | ||||||
| 16 June | ||||||
| 23 June | ||||||
| 30 June | "Funkytown" | Lipps Inc. | ||||
| 7 July | ||||||
| 14 July | ||||||
| 21 July | ||||||
| 28 July | "20 Greatest Hits" | Hot Chocolate | ||||
| 4 August | ||||||
| 11 August | ||||||
| 18 August | ||||||
| 25 August | ||||||
| 1 September | ||||||
| 8 September | "Xanadu" | Olivia Newton-John & ELO | ||||
| 15 September | "Xanadu" | Olivia Newton-John & ELO | ||||
| 22 September | "Santa Maria" | "Revanche" | Peter Maffay | |||
| 29 September | ||||||
| 6 October | ||||||
| 13 October | ||||||
| 20 October | ||||||
| 27 October | ||||||
| 3 November | "Santa Maria" | "Beautiful Moments" | Carpenters | |||
| 10 November | "Revanche" | Peter Maffay | ||||
| 17 November | ||||||
| 24 November | "James Last spielt Robert Stolz" | James Last | ||||
| 1 December | ||||||
| 8 December | "Woman in Love" | "Super Trouper" | ABBA | |||
| 15 December | "Träumereien 2" | Richard Clayderman | ||||
| 22 December | "Super Trouper" | "Super Trouper" | ABBA | |||
| 29 December | "Träumereien 2" | Richard Clayderman |