These are the Billboard magazine Hot Dance Club Play number one hits of 1978.
| Issue date | Song | Artist |
|---|---|---|
| January 7 | Once Upon a Time... (all cuts) | Donna Summer |
| January 14 | ||
| January 21 | "Supernature"/ "Give Me Love"/ "Love Is Here" | Cerrone |
| January 28 | ||
| February 4 | ||
| February 11 | ||
| February 18 | "Let's All Chant"/ "Love Express" | Michael Zager Band |
| February 25 | "Dance Little Dreamer"/ "Risky Changes" | Bionic Boogie |
| March 4 | ||
| March 11 | ||
| March 18 | "Romeo and Juliet" | Alec R. Costandinos & the Syncophonic Orchestra |
| March 25 | Come into My Heart (all cuts) | USA European Connection |
| April 1 | ||
| April 8 | Voyage (all cuts) | Voyage |
| April 15 | ||
| April 22 | ||
| April 29 | "If My Friends Could See Me Now"/ "Gypsy Lady"/ "Runaway Love" | Linda Clifford |
| May 6 | ||
| May 13 | ||
| May 20 | ||
| May 27 | ||
| June 3 | "Last Dance"/ "After Dark"/ "Thank God It's Friday"/ "Take It to the Zoo" | Donna Summer/ Pattie Brooks/ Love & Kisses/ Sunshine |
| June 10 | ||
| June 17 | ||
| June 24 | ||
| July 1 | ||
| July 8 | ||
| July 15 | "Boogie Oogie Oogie" | A Taste of Honey |
| July 22 | ||
| July 29 | ||
| August 5 | "Hot Shot" | Karen Young |
| August 12 | ||
| August 19 | "Dance (Disco Heat)"/ "You Make Me Feel (Mighty Real)" | Sylvester |
| August 26 | ||
| September 2 | ||
| September 9 | ||
| September 16 | ||
| September 23 | ||
| September 30 | "Keep on Jumpin'"/ "In the Bush" | Musique |
| October 7 | ||
| October 14 | Instant Replay (all cuts) | Dan Hartman |
| October 21 | "MacArthur Park Suite" | Donna Summer |
| October 28 | ||
| November 4 | ||
| November 11 | ||
| November 18 | ||
| November 25 | "Le Freak"/ "I Want Your Love"/ "Chic Cheer" | Chic |
| December 2 | ||
| December 9 | ||
| December 16 | ||
| December 23 | ||
| December 30 | ||