The following list is of important municipalities in Castilla-La Mancha, an autonomous community of Spain:
The following links are to lists which are more detailed province-specific, and all municipalities in a given province are ranked by population.
| Rank | Name | Population (2015) | ||
|---|---|---|---|---|
| 1 | Albacete | align=right | 173,362 | |
| 2 | Talavera de la Reina | align=right | 85,150 | |
| 3 | Guadalajara | align=right | 83,391 | |
| 4 | Toledo | align=right | 83,226 | |
| 5 | Ciudad Real | align=right | 74,427 | |
| 6 | Cuenca | align=right | 55,428 | |
| 7 | Puertollano | align=right | 50,035 | |
| 8 | Tomelloso | align=right | 37,645 | |
| 9 | Azuqueca de Henares | align=right | 34,896 | |
| 10 | Alcázar de San Juan | align=right | 31,269 | |
| 11 | Hellín | align=right | 30,592 | |
| 12 | Valdepeñas | align=right | 30,514 | |
| 13 | Villarrobledo | align=right | 25,989 | |
| 14 | Illescas | align=right | 25,964 | |
| 15 | Almansa | align=right | 24,837 | |
| 16 | Seseña | align=right | 21,558 | |
| 17 | Manzanares | align=right | 18,642 | |
| 18 | Daimiel | align=right | 18,577 | |
| 19 | La Roda | align=right | 16,978 | |
| 20 | La Solana | align=right | 15,739 |