List of therapeutic monoclonal antibodies explained

Therapeutic, diagnostic and preventive monoclonal antibodies are clones of a single parent cell. When used as drugs, the International Nonproprietary Names (INNs) end in -mab. The remaining syllables of the INNs, as well as the column Source, are explained in Nomenclature of monoclonal antibodies.The abbreviations in the column Type are as follows:

This list of over 500 monoclonal antibodies includes approved and investigational drugs as well as drugs that have been withdrawn from market; consequently, the column Use does not necessarily indicate clinical usage. See the list of FDA-approved therapeutic monoclonal antibodies in the monoclonal antibody therapy page.

Name Brand name Type Source Target Approved Use - mab mouse - mab mouse CA-125 (imitation) - ReoPro Fab chimeric CD41 (integrin alpha-IIb) Y[1] - mab humanized cancer - Fab humanized - mab human - mab human Clostridium difficile - Humira mab human Y[2] - mab human - Aduhelm mab human Y[3] - Afasevikumab mab human multiple sclerosis - F(ab')2 mouse - F(ab')2 humanized - Lemtrada, Campath mab humanized Y - Praluent mab human Y - Hybri-ceaker mab mouse Carcinoembryonic antigen (CEA) colorectal cancer (diagnosis) - mab chimeric cancer - Rybrevant BsAb human Y - Fab mouse Tumor-associated glycoprotein 72 (TAG-72) - mab chimeric gastric cancer or gastroesophageal junction adenocarcinoma - mab human mesothelin (MSLN) cancer - Saphnelo mab human Y[4] - Ebanga mab human Ebola virus glycoprotein Y treatment of Zaire ebolavirus (Ebola virus) - Anrukinzumab
(= IMA-638) 		mab humanized asthma - mab humanized hematological cancers - mab human - CEA-Scan Fab' mouse Carcinoembryonic antigen (CEA) gastrointestinal cancers (diagnosis) - mab human cancer - mab humanized L-selectin (CD62L) severely injured patients - Tecentriq mab humanized Y cancer - mab human - Atinumab mab human - mab human part of Atoltivimab/maftivimab/odesivimab for treatment of Zaire ebolavirus (Ebola virus) - Inmazeb mab human Y treatment of Zaire ebolavirus (Ebola virus) - mab human - Bavencio mab human Y cancer - Niktimvo mab humanized Y - mab chimeric/
humanized 		cancer - mab human spike protein receptor binding domain (RBD) of SARS-CoV-2 Emergency Use Authorization (EUA) when used with etesevimab[5] - mab humanized - Simulect mab chimeric CD25 (α chain of IL-2 receptor) Y prevention of organ transplant rejections - mab chimeric cancer, viral infections - human melanoma - mab human spike protein receptor binding domain (RBD) of SARS-CoV-2 Emergency Use Authorization (EUA)[6] - LymphoScan Fab' mouse non-Hodgkin's lymphoma (detection) - Librela[7] mab veterinary nerve growth factor (NGF) Y pain associated with osteoarthritis in dogs - mab mouse - Blenrep mab humanized B-cell maturation antigen (BCMA) Y (Withdrawn) relapsed or refractory multiple myeloma - Benlysta mab human B-cell activating factor (BAFF) Y systemic lupus erythematosus without renal or CNS involvement - Bemarituzumab mab humanized gastric cancer or gastroesophageal junction adenocarcinoma - Fasenra mab humanized Y asthma - mab human - Xilonix mab human - mab human - mab human CCL11 (eotaxin-1) severe allergic disorders - Scintimun mab mouse Carcinoembryonic antigen (CEA)-related antigen inflammatory lesions and metastases (detection) - Avastin mab humanized Y - Zinplava mab human Clostridium difficile Y - FibriScint Fab' mouse fibrin II, beta chain thromboembolism (diagnosis) - mab human myostatin inhibitor - Bimzelx mab humanized Y psoriasis - Birtamimab mab chimeric serum amyloid A protein - mab humanized CD44 v6 - mab human organ transplant rejection - Blincyto BiTE mouse Y pre-B Acute lymphoblastic leukemia (ALL) (CD19+) - Blontuvetmab Blontress mab veterinary - mab humanized osteoporosis - mab humanized - mab human Crohn's disease - Adcentris mab chimeric CD30 (TNFRSF8) Y - mab human - Siliq mab human Y - Beovu scFv humanized vascular endothelial growth factor A (VEGFA) Y wet age-related macular degeneration - mab humanized cancer - Crysvita mab human Y - mab humanized metastatic pancreatic cancer - mab human CD25 (α chain of IL-2 receptor) B-cell Hodgkin's lymphoma, non-Hodgkin lymphoma, acute lymphoblastic leukemia, acute myeloid leukemia - mab humanized - Ilaris mab human Y - mab humanized CanAg (a glycoform of MUC1) colorectal cancer etc. - mab humanized CanAg (a glycoform of MUC1) cancers - Cablivi sdAb humanized Y - mab human spike protein receptor binding domain (RBD) of SARS-CoV-2 Yes when used with imdevimab[8] [9] - Prostascint mab mouse Y prostate cancer (detection) - mab human oncology/immune indications - mab chimeric - Removab 3funct rat/mouse hybrid Y ovarian cancer, malignant ascites, gastric cancer - mab humanized cancer - mab humanized prevention of organ transplant rejections, treatment of autoimmune diseases - Libtayo mab human Y cutaneous squamous cell carcinoma - Cergutuzumab amunaleukin mab humanized cancer - Cimzia Fab' humanized Y - mab human cancer - Erbitux mab chimeric Epidermal growth factor receptor (EGFR) Y - mab humanized cancer - mab human spike protein receptor binding domain (RBD) of SARS-CoV-2 Emergency Use Authorization (EUA) when used with tixagevimab[10] - humanized chronic lymphocytic leukemia - Fab humanized ovarian cancer and other solid tumors - mab human solid tumors - mab humanized - mab chimeric - hPAM4-Cide mab humanized - mab humanized cancer - mab humanized cancer - mab chimeric cancer - mab human cancer - Alhemo mab humanized tissue factor pathway inhibitor (TFPI) Y - ZMapp mab chimeric ebolavirus glycoprotein Ebola virus - mab humanized - Adakveo mab humanized Y - mab human glucagon receptor (GCGR) diabetes - Piasky mab humanized Y - mab human infectious disease/influenza A - mab humanized cancer - mab humanized hematologic cancers - Zenapax mab humanized CD25 (α chain of IL-2 receptor) Y - mab humanized cancer etc. - mab humanized - Darzalex mab human Y[11] - mab human - mab humanized cancer - mab humanized cancer - Prolia mab human Y osteoporosis, bone metastases etc. - mab chimeric/
humanized 		EGFR glioblastoma - mab chimeric histone complex - mab mouse B-lymphoma cell lymphoma - mab humanized - Unituxin mab chimeric Y - Qarziba mab chimeric Y - mab human - Ivlizi mab humanized Y (Russia)[12] - mab humanized - Kisunla[13] mab humanized Y - F(ab')2 mouse - Jemperli mab humanized Y - mab human cancer etc. - humanized HER2 gastric or gastroesophageal junction adenocarcinoma - mab humanized testicular cancer - Dupixent mab human Y atopic dermatitis, asthma, nasal polyps - Imfinzi mab human Y cancer - mab human B-cell malignancies - scFv chimeric/
humanized 		cancer - mab chimeric malignant melanoma - Soliris mab humanized Y - mab mouse sepsis caused by Gram-negative bacteria - Panorex mab mouse colorectal carcinoma - Raptiva mab humanized LFA-1 (CD11a) psoriasis (blocks T-cell migration) - Mycograb scFv human - mab human - mab human repulsive guidance molecule A (RGMA) spinal cord injury and multiple sclerosis - mab human cancer - Empliciti mab humanized Y - mab mouse - mab humanized cancer - Gamifant mab human Y - mab humanized cancer - Hemlibra BsAb humanized Y - mab human cancer - mab humanized cancer etc. - Padcev mab human nectin-4 Y[14] - mab mouse ICAM-1 (CD54) - mab humanized cancer - mab humanized asthma - mab human - mab chimeric cancer - Epkinly BiTE humanized Y - mab mouse episialin - mab humanized cancer, systemic lupus erythematosus (SLE) - Vyepti mab humanized calcitonin gene-related peptide Y[15] migraine - Aimovig mab human calcitonin gene-related peptide receptor (CGRP) Y migraine - F(ab')2 humanized ITGB2 (CD18) - Rexomun 3funct rat/mouse hybrid Y breast cancer etc. - Abegrin mab humanized Y melanoma, prostate cancer, ovarian cancer etc. - mab human spike protein receptor binding domain (RBD) of SARS-CoV-2 Emergency Use Authorization (EUA) when used with bamlanivimab - mab humanized TIGIT - mab humanized - Evkeeza mab human angiopoietin 3 Y - Repatha mab human Y - mab human hepatitis B surface antigen hepatitis B - NeutroSpec mab mouse appendicitis (diagnosis) - mab mouse - Vabysmo mab humanized VEGF-A and Ang-2 Y angiogenesis, ocular vascular diseases - mab humanized ovarian cancer - mab human nerve growth factor (NGF) acute sciatic pain - FBTA05[16] [17] Lymphomun 3funct rat/mouse hybrid - mab humanized respiratory syncytial virus infection - mab human - mab humanized - mab humanized Hepatocyte growth factor (HGF) cancer etc. - mab human adrenocortical carcinoma, non-small cell lung carcinoma etc. - mab human - mab human TYRP1 (glycoprotein 75) melanoma - mab human - di-scFv humanized hematological malignancies - HuZAF mab humanized Crohn's disease etc. - mab human - mab human rabies virus glycoprotein rabies (prophylaxis) - Ajovy mab humanized calcitonin gene-related peptide alpha and beta Y - mab human idiopathic pulmonary fibrosis, focal segmental glomerulosclerosis, cancer - Frovocimab mab humanized - Solensia[18] mab veterinary nerve growth factor (NGF) Y pain associated with osteoarthritis in cats - mab human nerve growth factor (NGF) pain - mab chimeric Epidermal growth factor receptor (EGFR) cancer - Emgality mab humanized Y - mab chimeric - Gancotamab scFv human cancer - mab human cancer - mab human - mab humanized cancer - mab mouse CD147 (basigin) - mab human - Mylotarg mab humanized Y - mab humanized diabetes etc. - Gilvetmab mab veterinary - Gimsilumab mab human - Rencarex mab chimeric carbonic anhydrase 9 (CA-IX) clear cell renal cell carcinoma[19] - mab human - Columvi BsAb humanized Y[20] - Simponi mab human Y rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis - mab chimeric CD23 (IgE receptor) - Gosuranemab mab humanized - Tremfya mab human Y - mab human autoimmune hepatitis - Trogarzo mab humanized Y - human - Zevalin mab mouse Y non-Hodgkin's lymphoma - mab human cancer etc. - Praxbind mab humanized Y reversal of anticoagulant effects of dabigatran - mab humanized glioblastoma multiforme[21] - Indimacis-125 F(ab')2 mouse ovarian cancer (diagnosis) - mab humanized cancer - mab human macrophage migration inhibitory factor (MIF) cancer - mab humanized melanoma cell adhesion molecule (MCAM) - Myoscint mab mouse Y cardiac imaging - mab human spike protein receptor binding domain (RBD) of SARS-CoV-2 Yes when used with casirivimab - mab humanized Epidermal growth factor receptor (EGFR) cancer - mab human selectin P cardiovascular disease - mab chimeric cancer - mab human cancer - Uplizna mab humanized Y[22] - Remicade mab chimeric Y rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, psoriasis, Crohn's disease, ulcerative colitis - mab human solid tumors (prostate cancer, melanoma) - mab mouse CD25 (α chain of IL-2 receptor) graft versus host disease - Besponsa mab humanized Y Acute lymphoblastic leukemia (ALL) - Yervoy mab human Y - mouse ablation of bone marrow - mab human CD30 (TNFRSF8) - Sarclisa mab chimeric Y multiple myeloma - mab human CD40 - mab human advanced solid tumors - Alzumab mab humanized Y psoriasis - Taltz mab humanized Y autoimmune diseases - mab mouse Kappa Myeloma Antigen (KMA) multiple myeloma - mab chimeric chronic asthma - CEA-Cide mab humanized Carcinoembryonic antigen (CEA) - mab humanized CSF1, macrophage colony stimulating factor (MCSF) cancer - mab humanized cancer - Fab humanized Complement factor D (CFD) geographic atrophy secondary to age-related macular degeneration - Takhzyro mab human Y - mab humanized muscle wasting disorders - mab chimeric epidermal growth factor receptor (EGFR) - mab chimeric ebolavirus glycoprotein Ebola virus - mab humanized - Leqembi mab humanized Y[23] - mab mouse NCA-90 (granulocyte antigen) diagnostic agent - mab humanized C5 - mab humanized hepatitis B surfage antigen hepatitis B - mab human - mab human - mab humanized CCR5 breast cancer, HIV - mab human - scFv humanized tumor necrosis factor related activation protein (TRAP) inflammatory diseases - mab human cancer - mab human hepatitis B surface antigen hepatitis B - mab humanized phosphate-sodium co-transporter cancer - mab humanized - Zynlonta mab chimeric Y relapsed or refractory large B-cell lymphoma - mab chimeric/
humanized 		cancer - mab mouse cancer - mab humanized cancer - mab human solid and hematological cancers - mab humanized - Cytopoint[24] mab veterinary Y clinical signs of atopic dermatitis in dogs - mab humanized cancer - mab human - mab humanized autoimmune diseases - mab chimeric CD23 (IgE receptor) - mab humanized cancer - mab human - mab human LYPD3 - mab humanized - mab human part of Atoltivimab/maftivimab/odesivimab for treatment of Zaire ebolavirus (Ebola virus) - mab human TRAIL-R1 cancer - Margenza[25] mab humanized HER2 Y - mab human tissue factor pathway inhibitor (TFPI) - mouse T-cell receptor - mab human - mab humanized Epidermal growth factor receptor (EGFR) colorectal, lung and stomach cancer - Bosatria mab humanized Y asthma and white blood cell diseases - mab human - mab humanized multiple myeloma and other hematological malignancies - mab mouse tumor detection (and therapy?) - Omvoh mab humanized Y - Elahere mab chimeric Y[26] ovarian cancer - mab mouse - mab chimeric EGFR extracellular domain III cancer - Poteligeo mab humanized Y - mab humanized NKG2A rheumatoid arthritis, gynecologic malignancies, and other cancers - mab human - Lunsumio BiTE humanized Y[27] follicular lymphoma - Numax mab humanized respiratory syncytial virus (prevention) - Lumoxiti mab mouse Y - Muromonab-CD3[28] [29] Orthoclone OKT3 mab mouse prevention of organ transplant rejections - Fab mouse C242 antigen - mab human - Fab mouse - mab chimeric - mab human MST1R (aka RON) cancer - Tysabri mab humanized Y multiple sclerosis, Crohn's disease - mab chimeric/
humanized 		cancer - mab human - Danyelza humanized c-Met Y high-risk neuroblastoma and refractory osteomedullary disease - mab human sepsis - Portrazza mab human Epidermal growth factor receptor (EGFR) Y non-small cell lung carcinoma - mab humanized eczema[30] - humanized amyloid - mab mouse - mab human cancer - Efleira mab humanized Y (Russia)[31] plaque psoriasis, psoriatic arthritis, ankylosing spondylitis - BioMab-EGFR, Theracim, Theraloc mab humanized epidermal growth factor receptor (EGFR) Y - mab human - Opdivo mab human Y cancer - Verluma Fab mouse cancer (diagnosis) - Anthim mab chimeric Bacillus anthracis anthrax Y Bacillus anthracis spores - Gazyva mab humanized Y - mab humanized cancer - Ocrevus mab humanized Y - mab human part of Atoltivimab/maftivimab/odesivimab for treatment of Zaire ebolavirus (Ebola virus) - mab mouse LFA-1 (CD11a) prevention of organ transplant rejections, immunological diseases - Arzerra, Kesimpta[32] mab human Y - Lartruvo mab human Y cancer - mab human - mab humanized complement C5a - mab humanized - Xolair mab humanized Y - Omburtamab mab mouse CD276 cancer - human MASP-2 atypical hemolytic uremic syndrome - Fab humanized human scatter factor receptor kinase cancer - mab chimeric/
humanized 		cancer - mab human VISTA (protein) (VSIR) - mab human LINGO-1 - Vicinium scFv humanized - OvaRex mab mouse ovarian cancer - mab human - mab chimeric/
humanized 		diabetes mellitus type 1 - Otilimab mab human GMCSF - mab humanized cancer - mab human asthma - mab humanized NOGO-A - mab humanized inflammation - mab chimeric sepsis (Staphylococcus) - Synagis, Abbosynagis mab humanized Y respiratory syncytial virus (prevention) - mab human connective tissue growth factor (CTGF) idiopathic pulmonary fibrosis (IPF), pancreatic cancer - Vectibix mab human epidermal growth factor receptor (EGFR) Y - mab humanized ovarian cancer - mab human Pseudomonas aeruginosa Pseudomonas aeruginosa infection - mab humanized cancer - mab humanized asthma - mab chimeric/
humanized 		cancer - mab humanized lymphotoxin alpha (LTA) - mab human cancer - humanized melanoma - Keytruda mab humanized Y[33] melanoma and other cancers - Pemgarda mab human spike protein receptor binding domain (RBD) of SARS-CoV-2 Emergency Use Authorization (EUA)[34] - Theragyn mouse cancer - mab humanized - Perjeta mab humanized Y cancer - scFv humanized C5 - mab humanized cancer and infectious diseases - mab humanized cancer - mab mouse adenocarcinoma antigen adenocarcinoma (imaging) - mab human pain and inflammatory diseases - Veopoz mab human Y CHAPLE disease - mab human - mab humanized - mab humanized tumor necrosis factor receptor (TNFR) superfamily member 4 - Polivy mab humanized Y - mab humanized - mab chimeric Zaire ebolavirus glycoprotein - mab humanized - mab humanized inducible T-cell co-stimulatory ligand (ICOSL) - mab chimeric Crohn's disease, multiple sclerosis - mab chimeric E. coli shiga toxin type-1 - mab human - humanized - mab humanized IGHE asthma - Vaxira mab mouse NGNA ganglioside Y non-small cell lung cancer - mab human fibronectin extra domain-B cancer - mab human rabies virus glycoprotein rabies (prophylaxis) - mab humanized - Cyramza mab human Y solid tumors - Ranevetmab mab veterinary NGF osteoarthritis in dogs - Lucentis Fab humanized Y macular degeneration (wet form) - mab human anthrax toxin, protective antigen Y anthrax (prophylaxis and treatment) - mab humanized CD40 Crohn's disease - Ultomiris mab humanized C5 Y - mab humanized myelin-associated glycoprotein recovery of motor function after stroke - mab human cytomegalovirus glycoprotein B cytomegalovirus infection - Regkirona[35] mab human spike protein receptor binding domain (RBD) of SARS-CoV-2 Y - mab human melanoma - mab human - Cinqair mab humanized Y inflammations of the airways, skin and gastrointestinal tract - Zynyz[36] mab humanized Y - mab human hepatocyte growth factor (HGF) solid tumors - mab human neovascular age-related macular degeneration - Skyrizi mab humanized Y Crohn's disease, psoriasis, psoriatic arthritis, and asthma - MabThera, Rituxan mab chimeric Y[37] lymphomas, leukemias, some autoimmune disorders - mab humanized Pseudomonas aeruginosa type III secretion system - mab human cancer - RabiShield human rabies virus G glycoprotein Y post-exposure prophylaxis of rabies - mab human RHD (gene) (RHD) - mab chimeric/
humanized 		- Evenity mab humanized Y - mab humanized - mab humanized root plate-specific spondin 3 cancer - mab humanized small cell lung cancer - LeukArrest mab humanized Y haemorrhagic shock etc. - Rystiggo mab chimeric/
humanized 		FCGRT Y[38] - Antova mab humanized CD154 (CD40L) Y rheumatic diseases - humanized neuromyelitis optica and neuromyelitis optica spectrum disorders - Trodelvy mab humanized TROP-2 Y[39] - mab humanized cancer - mab chimeric/
humanized 		LRRC15 cancer - Kevzara mab human Y - Enspryng mab humanized Y - mab mouse cancer (diagnosis) - Cosentyx mab human Y - mab human - mab human cancer - mab chimeric E. coli shiga toxin type-2 - mab human sclerostin (SOST) - human cytomegalovirus infection - mab humanized FAP (gene) (FAP) cancer - mab humanized acute lymphoblastic leukemia and B-cell non-Hodgkin lymphoma - human mucosal addressin cell adhesion molecule Crohn's disease - mab human - Sylvant mab chimeric Y cancer - mab humanized - mab humanized psoriasis, graft-versus-host disease (prevention) - mab human cancer - mab human - mab humanized ovarian cancer - mab humanized - BiTE mouse gastrointestinal, lung, and other cancers - Sonepcizumab[40] humanized - mab humanized episialin - Xevudy mab human spike protein receptor binding domain (RBD) of SARS-CoV-2 Y[41] [42] - mab humanized melanoma - Spevigo mab humanized Interleukin 36 receptor (IL1RL2/IL1RAP) Y generalized pustular psoriasis (GPP) - mab human muscular dystrophy - mab human - LeukoScan Fab' mouse NCA-90 (granulocyte antigen) osteomyelitis (imaging) - mab human RSVFR - Enjaymo mab chimeric/
humanized 		complement component 1s (C1s) Y - mab humanized viral infections - mab human - mab human B-cell activating factor (BAFF) B-cell cancers - AFP-Cide mab humanized cancer - Fab humanized integrin αIIbβ3 - Monjuvi mab humanized
(from mouse) 		Y relapsed or refractory diffuse large B-cell lymphoma - mab humanized leukemia etc. - mab humanized - Talvey BsAb humanized Y - Tamtuvetmab Tactress mab veterinary - mab humanized nerve growth factor (NGF) - mab mouse cancer - mab human Notch receptor cancer - Imdelltra[43] BsAb human Y - Tavolimab mab chimeric/
humanized 		CD134 cancer - Tecvayli BsAb human Y[44] [45] - Aurexis mab humanized Staphylococcus aureus infection - Fab mouse - mab humanized cancer - mab humanized cancer - mab mouse cancer - mab chimeric - Tzield mab humanized Y - mab human cancer - Tepezza mab human Y - mab human - mab humanized cancer[46] - Tezspire mab human thymic stromal lymphopoietin (TSLP) Y[47] - humanized - Tibulizumab mab humanized B-cell activating factor (BAFF) autoimmune disorders - Ilumya mab humanized Y immunologically mediated inflammatory disorders - mab humanized cancer - mab humanized cancer - mab human - mab human - mab human cancer - mab humanized - Tivdak mab human Y relapsed or refractory cervical cancer[48] [49] - mab human spike protein receptor binding domain (RBD) of SARS-CoV-2 Emergency Use Authorization (EUA) when used with cilgavimab - humanized - Actemra, RoActemra mab humanized Y[50] - mab humanized cancer - mab humanized CD154 (CD40L) rheumatoid arthritis, lupus nephritis etc. - mab human Staphylococcus aureus - Bexxar mouse Y - mab human cancer - Adtralza, Adbry[51] mab human Y atopic dermatitis - Herceptin mab humanized Y - Kadcyla mab humanized Y - Kadcyla mab humanized Y - TRBS07[52] Ektomab 3funct melanoma - mab humanized - Imjudo mab human Y[53] - mab human growth differentiation factor 8 - mab humanized cancer - human hepatitis B virus chronic hepatitis B - Briumvi mab chimeric CD20 Y multiple sclerosis, chronic lymphocytic leukemia - mab human hematologic malignancies - mab human 4-1BB (CD137) cancer etc. - mab humanized Escherichia coli diarrhoea caused by E. coli - Stelara mab human Y multiple sclerosis, psoriasis, psoriatic arthritis - mab human 4-1BB (CD137) diffuse large B-cell lymphoma - mab chimeric - mab humanized CD40 - mab humanized cancer - mab human cancer - mab humanized cancer - mab chimeric AOC3 (VAP-1) - mab human angiogenesis - mab human solid tumors and hematologic malignancies - mab humanized ITGA2 (CD49b) - Entyvio mab humanized Y[54] - mab humanized non-Hodgkin's lymphoma - mab mouse AOC3 (VAP-1) inflammation - Vesencumab mab human solid malignancies - Gohibic mab chimeric C5a receptor (C5a) Emergency Use Authorization (EUA)[55] - Nuvion mab humanized Crohn's disease, ulcerative colitis - scFv humanized inflammatory autoimmune diseases - mab chimeric integrin α5β1 solid tumors - mab humanized cancer - mab humanized CD278, aka ICOS - mab humanized cancer - HumaSPECT mab human tumor antigen CTAA16.88 colorectal tumors - mab humanized - mab humanized ? - humanized CD19 diffuse large B-cell lymphoma - mab human Epidermal growth factor receptor (EGFR) - mab human rheumatoid arthritis, psoriasis, T-cell lymphoma - mab chimeric cancer - mab humanized cancer - mab human CD147 (basigin) - Vyloy[56] mab chimeric Y - mab mouse systemic lupus erythematosus, graft-versus-host disease

Notes and References

  1. Web site: ReoPro Abciximab . DailyMed . 4 May 2020 . 28 June 2022 . 6 September 2022 . https://web.archive.org/web/20220906054525/https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=486252 . live .
  2. Web site: Humira- adalimumab kit Humira- adalimumab injection, solution . DailyMed . 18 February 2020 . 21 June 2020 . https://web.archive.org/web/20200621160349/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=608d4f0d-b19f-46d3-749a-7159aa5f933d#section-1 . live .
  3. Web site: Aduhelm- aducanumab injection, solution . DailyMed . 14 June 2021 . 14 June 2021 . https://web.archive.org/web/20210614225021/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=41706573-546f-6774-6872-5374726f6e67 . live .
  4. Web site: Saphnelo- anifrolumab injection, solution . DailyMed . 11 August 2021 . 12 August 2021 . https://web.archive.org/web/20210812053122/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d6203302-2128-41a7-b0b4-0e6c0704d4dc . live .
  5. Web site: Fact Sheet For Health Care Providers Emergency Use Authorization (EUA) Of Bamlanivimab and Etesevimab . PDF . U.S. Food and Drug Administration (FDA) . 18 March 2021 . 18 March 2021 . https://web.archive.org/web/20210318145534/https://www.fda.gov/media/145802/download . live .
  6. Web site: Fact Sheet For Health Care Providers Emergency Use Authorization (EUA) Of Bebtelovimab . PDF . U.S. Food and Drug Administration (FDA) . 12 February 2022 . 11 February 2022 . https://web.archive.org/web/20220211204138/http://www.fda.gov/media/156152/download . live .
  7. Zoetis Announces U.S. FDA Approval of Librela (bedinvetmab injection) to Control Osteoarthritis (OA) Pain in Dogs . Zoetis . Business Wire . 5 May 2023 . 13 May 2023 . 6 May 2023 . https://web.archive.org/web/20230506023701/http://www.businesswire.com/news/home/20230505005475/en/Zoetis-Announces-U.S.-FDA-Approval-of-Librela%E2%84%A2-bedinvetmab-injection-to-Control-Osteoarthritis-OA-Pain-in-Dogs/ . live .
  8. Web site: Ronapreve EPAR . European Medicines Agency . 10 November 2021 . 12 November 2021 . 13 November 2021 . https://web.archive.org/web/20211113183418/https://www.ema.europa.eu/en/medicines/human/EPAR/ronapreve . live .
  9. Japan becomes first country to approve Ronapreve (casirivimab and imdevimab) for the treatment of mild to moderate COVID-19 . Roche . 20 July 2021 . 29 August 2021 . 24 July 2021 . https://web.archive.org/web/20210724035234/https://www.roche.com/media/releases/med-cor-2021-07-20.htm . live .
  10. Coronavirus (COVID-19) Update: FDA Authorizes New Long-Acting Monoclonal Antibodies for Pre-exposure Prevention of COVID-19 in Certain Individuals . U.S. Food and Drug Administration (FDA) . 8 December 2021 . 9 December 2021 . 28 April 2022 . https://web.archive.org/web/20220428174550/https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-new-long-acting-monoclonal-antibodies-pre-exposure . live .
  11. Web site: Darzalex- daratumumab injection, solution, concentrate Darzalex IV- daratumumab injection, solution, concentrate . DailyMed . 18 December 2021 . 19 December 2021 . https://web.archive.org/web/20211219013316/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a4d0efe9-5e54-467e-9eb4-56fa7d53b60b . live .
  12. Web site: Ivlizi (divozilimab) Concentrate for Solution for Infusion. Full Prescribing Information . 28 January 2024 . Russian State Register of Medicines . JSC Biocad . ru.
  13. FDA approves treatment for adults with Alzheimer's disease . U.S. Food and Drug Administration (FDA) . 2 July 2024 . 2 July 2024 . 2 July 2024 . https://web.archive.org/web/20240702222134/https://www.fda.gov/drugs/news-events-human-drugs/fda-approves-treatment-adults-alzheimers-disease . live .
  14. Web site: Padcev ejfv- enfortumab vedotin injection, powder, lyophilized, for solution . DailyMed . 18 December 2021 . 11 December 2021 . https://web.archive.org/web/20211211113318/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b5631d3e-4604-4363-8f20-11dfc5a4a8ed . live .
  15. Web site: Vyepti- eptinezumab-jjmr injection . DailyMed . 27 September 2021 . 28 September 2021 . https://web.archive.org/web/20210928051812/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=79065861-6aa5-4d1f-829f-3a6471286b36 . live .
  16. Buhmann. R . Immunotherapy of recurrent B–cell malignancies after allo SCT with Bi20 (FBTA05), a trifunctional anti-CD3 x anti-CD20 antibody and donor lymphocyte infusion. Bone Marrow Transplantation . 43 . 5. 383–397 . 2008 . 18850012 . Simoes . B . Stanglmaier . M . Yang . T . Faltin . M . Bund . D . Lindhofer . H . Kolb . HJ . 10.1038/bmt.2008.323. etal. free .
  17. Boehrer. S . Cytotoxic effects of the trifunctional bispecific antibody FBTA05 in ex-vivo cells of chronic lymphocytic leukaemia depend on immune-mediated mechanisms . Anti-Cancer Drugs . 12 . 10. 3085–3091 . 2011 . 10.1097/CAD.0b013e328344887f . 21637160 . Schroeder . Petra . Mueller . Tina . Atz . Judith . Chow . Kai Uwe. 29327089 . etal.
  18. FDA Approves Novel Treatment to Control Pain in Cats with Osteoarthritis, First Monoclonal Antibody Drug for Use in Any Animal Species . U.S. Food and Drug Administration (FDA) . 13 January 2022 . 14 January 2022 . 13 January 2022 . https://web.archive.org/web/20220113154907/https://www.fda.gov/news-events/press-announcements/fda-approves-novel-treatment-control-pain-cats-osteoarthritis-first-monoclonal-antibody-drug-use-any . live .
  19. Prometheus Obtains Exclusive US Commercialization Rights for RENCAREX® . 2 May 2011 . 7 July 2017 . https://web.archive.org/web/20170707225516/http://www.prnewswire.com/news-releases/prometheus-obtains-exclusive-us-commercialization-rights-for-rencarex-121075044.html . live .
  20. FDA approves Roche's Columvi, the first and only bispecific antibody with a fixed-duration treatment for people with relapsed or refractory diffuse large B-cell lymphoma . F. Hoffmann-La Roche Ltd . GlobeNewswire . 16 June 2023 . 16 June 2023 .
  21. Web site: Results from Cure Brain Cancer Foundation-funded trial show promise. www.curebraincancer.org.au. 14 June 2019. 19 March 2020. https://web.archive.org/web/20200319004011/https://www.curebraincancer.org.au/news/1752/results-from-cure-brain-cancer-foundation-funded-trial-show-promise. live.
  22. Web site: Uplizna- inebilizumab injection . DailyMed . 8 July 2019 . 13 June 2020 . 13 June 2020 . https://web.archive.org/web/20200613184027/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0ce5e7f6-eb97-4738-8b10-43b89e16b5b3 . live .
  23. FDA Grants Accelerated Approval for Alzheimer's Disease Treatment . U.S. Food and Drug Administration (FDA) . 6 January 2023 . 7 January 2023 . 7 January 2023 . https://web.archive.org/web/20230107000220/https://www.fda.gov/news-events/press-announcements/fda-grants-accelerated-approval-alzheimers-disease-treatment . live .
  24. News: Guthrie . Arlo . Zoetis launches breakthrough treatment for canine atopic dermatitis . 6 July 2018 . VetNurse News . 27 June 2017 . 7 July 2018 . https://web.archive.org/web/20180707041223/https://www.vetnurse.co.uk/b/veterinary-nursing-news/archive/2017/06/27/zoetis-launches-breakthrough-treatment-for-canine-atopic-dermatitis.aspx . live .
  25. Web site: Margenza: FDA-Approved Drugs . U.S. Food and Drug Administration (FDA) . 17 December 2020 . 23 March 2021 . https://web.archive.org/web/20210323184034/https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=761150 . live .
  26. Web site: FDA grants accelerated approval to mirvetuximab soravtansine-gynx for FRα positive, platinum-resistant epithelial ovarian, fallopian tube, or peritoneal cancer . U.S. Food and Drug Administration (FDA) . 14 November 2022 . 18 November 2022 . 18 November 2022 . https://web.archive.org/web/20221118062737/https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-mirvetuximab-soravtansine-gynx-fra-positive-platinum-resistant . live .
  27. Web site: FDA grants accelerated approval to mosunetuzumab-axgb . U.S. Food and Drug Administration . 22 December 2022 . 3 January 2023 . 4 January 2023 . https://web.archive.org/web/20230104033950/https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-mosunetuzumab-axgb-relapsed-or-refractory-follicular-lymphoma . live .
  28. Wilde. Michelle I.. Goa. Karen L.. 1 May 1996. Muromonab CD3. Drugs. en. 51. 5. 865–894. 10.2165/00003495-199651050-00010. 8861551. 13220985. 1179-1950. free.
  29. Hooks. M. A.. Wade. C. S.. Millikan. W. J.. 1991. Muromonab CD-3: a review of its pharmacology, pharmacokinetics, and clinical use in transplantation. Pharmacotherapy. 11. 1. 26–37. 10.1002/j.1875-9114.1991.tb03595.x . 0277-0008. 1902291. 10 September 2021. 10 September 2021. https://web.archive.org/web/20210910224913/https://pubmed.ncbi.nlm.nih.gov/1902291/. live.
  30. 10.1056/NEJMoa1606490. 28249150. Anti–Interleukin-31 Receptor a Antibody for Atopic Dermatitis. New England Journal of Medicine. 376. 9. 826–835. 2017. Ruzicka. Thomas. Hanifin. Jon M.. Furue. Masutaka. Pulka. Grazyna. Mlynarczyk. Izabela. Wollenberg. Andreas. Galus. Ryszard. Etoh. Takafumi. Mihara. Ryosuke. Yoshida. Hiroki. Stewart. Jonathan. Kabashima. Kenji. XCIMA Study Group. 205100502. free.
  31. Web site: Efleira (netakimab) Solution for Subcutaneous Use. Full Prescribing Information . 28 January 2024 . Russian State Register of Medicines . JSC Biocad . ru.
  32. FDA approves Novartis Kesimpta (ofatumumab), the first and only self-administered, targeted B-cell therapy for patients with relapsing multiple sclerosis . 21 August 2020 . 20 August 2020 . Novartis . 24 September 2020 . https://web.archive.org/web/20200924215304/https://www.novartis.com/news/media-releases/fda-approves-novartis-kesimpta-ofatumumab-first-and-only-self-administered-targeted-b-cell-therapy-patients-relapsing-multiple-sclerosis . live .
  33. Web site: Keytruda- pembrolizumab injection, powder, lyophilized, for solution Keytruda- pembrolizumab injection, solution . DailyMed . 17 September 2019 . 10 January 2020 . 17 June 2020 . https://web.archive.org/web/20200617124927/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9333c79b-d487-4538-a9f0-71b91a02b287 . live .
  34. Web site: FDA Roundup: March 22, 2024 . U.S. Food and Drug Administration (FDA) . 22 March 2024 . 23 March 2024.
  35. Web site: Regkirona EPAR . European Medicines Agency . 10 November 2021 . 12 November 2021 . 12 November 2021 . https://web.archive.org/web/20211112234216/https://www.ema.europa.eu/en/medicines/human/EPAR/regkirona . live .
  36. Web site: ZYNYZ™ (retifanlimab-dlwr) injection, for intravenous use . 23 March 2023 . live . 23 March 2023 . https://web.archive.org/web/20230323054836/https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/761334s000lbl.pdf.
  37. Web site: 6 November 2019. Rituxan- rituximab injection, solution. 2 February 2020. DailyMed. 4 August 2020. https://web.archive.org/web/20200804180021/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b172773b-3905-4a1c-ad95-bab4b6126563. live.
  38. UCB announces U.S. FDA approval of Rystiggo (rozanolixizumab-noli) for the treatment of adults with generalized myasthenia gravis . UCB . PR Newswire . 27 June 2023 . 28 June 2023.
  39. Web site: Trodelvy- sacituzumab govitecan powder, for solution . DailyMed . 9 April 2021 . 20 March 2021 . https://web.archive.org/web/20210320205956/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=57a597d2-03f0-472e-b148-016d7169169d . live .
  40. 10.1002/jcp.21588 . Blockade of Sphingosine-1-phosphate Reduces Macrophage Influx and Retinal and Choroidal Neovascularization . 2009 . Xie . B. . Shen . J. . Dong . A. . Rashid . A. . Stoller . 2905312 . G. . Campochiaro . P. A. . Journal of Cellular Physiology . 218 . 192–198 . 18781584 . 1 .
  41. Web site: AusPAR: Sotrovimab . Therapeutic Goods Administration (TGA) . 20 August 2021 . 4 September 2021 . 1 November 2021 . https://web.archive.org/web/20211101082146/https://www.tga.gov.au/auspar/auspar-sotrovimab . live .
  42. Web site: Xevudy EPAR . European Medicines Agency (EMA) . 15 December 2021 . 17 December 2021 . 18 December 2021 . https://web.archive.org/web/20211218074403/https://www.ema.europa.eu/en/medicines/human/EPAR/xevudy . live .
  43. Web site: FDA grants accelerated approval to tarlatamab-dlle for extensive stage small cell lung cancer . U.S. Food and Drug Administration (FDA) . 16 May 2024 . 17 May 2024.
  44. Janssen Marks First Approval Worldwide for Tecvayli (teclistamab) with EC Authorisation of First-in-Class Bispecific Antibody for the Treatment of Patients with Multiple Myeloma . Janssen Pharmaceutical Companies . 24 August 2022 . 26 October 2022 . 26 October 2022 . https://web.archive.org/web/20221026192404/https://www.jnj.com/janssen-marks-first-approval-worldwide-for-tecvayli-teclistamab-with-ec-authorisation-of-first-in-class-bispecific-antibody-for-the-treatment-of-patients-with-multiple-myeloma . live .
  45. Web site: U.S. FDA Approves Tecvayli (teclistamab-cqyv), the First Bispecific T-cell Engager Antibody for the Treatment of Patients with Relapsed or Refractory Multiple Myeloma . Janssen Pharmaceutical Companies . 25 October 2022 . 26 October 2022.
  46. Jostein Dahle . Ada H. V. Repetto-Llamazares . Camilla S. Mollatt . Katrine B. Melhus . Oyvind S. Bruland . Arne Kolstad . Roy H. Larsen . Evaluating antigen targeting and anti-tumor activity of a new anti-CD37 radioimmunoconjugate against non-Hodgkin's lymphoma . . 33 . 1 . 85–95 . January 2013 . 23267131.
  47. Web site: Tezspire- tezepelumab-ekko injection, solution . DailyMed . 17 December 2021 . 28 June 2022 . 25 December 2021 . https://web.archive.org/web/20211225032358/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=60f0aa03-ad25-4d48-80ce-7fcfa76f325f . live .
  48. Wright. Rob. 13 February 2018. Seattle Genetics Legacy Of Partnering. Life Science Leader. Beyond The Printed Page. 22 February 2018. 23 February 2018. https://web.archive.org/web/20180223023846/https://www.lifescienceleader.com/doc/seattle-genetics-legacy-of-partnering-0001. live.
  49. Web site: Enforcement Reports. 21 September 2021. 21 September 2021. https://web.archive.org/web/20210921051657/https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/761208s000lbl.pdf. live.
  50. Web site: RoActemra EPAR . European Medicines Agency . 17 September 2018 . 18 December 2021 . 18 December 2021 . https://web.archive.org/web/20211218083546/https://www.ema.europa.eu/en/medicines/human/EPAR/roactemra . live .
  51. LEO Pharma announces FDA approval of Adbry tralokinumab . LEO Pharma . 28 December 2021 . 28 December 2021 . https://web.archive.org/web/20211228121841/https://www.leo-pharma.com/media-center/news/leo-pharma-announces-fda-approval-of-adbry-tralokinumab . live .
  52. Ruf. P . Two new trifunctional antibodies for the therapy of human malignant melanoma . International Journal of Cancer . 108 . 725–732 . 2004 . 14696099 . 10.1002/ijc.11630 . Jäger . M . Ellwart . J . Wosch . S . Kusterer . E . Lindhofer . H . 5. 25197165 . etal. free .
  53. Imjudo (tremelimumab) in combination with Imfinzi approved in the US for patients with unresectable liver cancer . AstraZeneca . 26 October 2022 . 26 October 2022 . 24 October 2022 . https://web.archive.org/web/20221024124047/https://www.astrazeneca.com/media-centre/press-releases/2022/imfinzi-and-imjudo-approved-in-advanced-liver-cancer.html . live .
  54. Web site: Entyvio- vedolizumab injection, powder, lyophilized, for solution . DailyMed . 3 April 2020 . 12 October 2020 . 21 October 2020 . https://web.archive.org/web/20201021195924/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6e94621c-1a95-4af9-98d1-52b9e6f1949c . live .
  55. Web site: FDA authorizes Gohibic (vilobelimab) injection for the treatment of COVID-19 . U.S. Food and Drug Administration (FDA) . 4 April 2023 . 4 April 2023.
  56. Astellas' Vyloy (zolbetuximab) Approved in Japan for Treatment of Gastric Cancer . Astellas Pharma . PR Newswire . 26 March 2024 . 19 April 2024.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "List of therapeutic monoclonal antibodies".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.