List of largest selling pharmaceutical products explained

Best selling pharmaceuticals of U.S. market

The top 5 best selling pharmaceuticals 2015–2019. Sales in billion USD.^[1]

Rank	Drug	Main indication	Trade name	2015	2016	2017	2018	2019
1	adalimumab	rheumatoid arthritis	Humira	10.1	13.5	16.3	18.4	21.4
2	apixaban	anticoagulant	Eliquis	1.6	3.0	4.6	7.1	9.9
3	etanercept	rheumatoid arthritis	Enbrel	7.2	7.6	7.9	8.0	8.1
4	ustekinumab	psoriasis	Stelara	2.0	2.6	3.7	5.0	6.6
5	pembrolizumab	oncology	Keytruda	0.4	0.7	2.2	4.3	6.5

Best selling pharmaceuticals of 2017/18

The top 16 best selling pharmaceuticals of 2017/18.^[2]

!Rank!Drug!Main indication!Trade name!2018 sales (million USD)!2017 sales (million USD)

1	adalimumab	rheumatoid arthritis	Humira	19 936	18427
3	apixaban	anticoagulant	Eliquis	9872	7395
4	lenalidomide	multiple myeloma	Revlimid	9685	8187
5	nivolumab	oncology	Opdivo	7570	5763
6	pembrolizumab	oncology	Keytruda	7171	3809
7	etanercept	rheumatoid arthritis	Enbrel	7126	7885
8	trastuzumab	breast cancer	Herceptin	6981	7013
9	bevacizumab	colon cancer	Avastin	6847	6686
10	rituximab	non-Hodgkin's lymphoma	Rituxan, MabThera	6750	7298
11	rivaroxaban	anticoagulant	Xarelto	6589	6234
12	aflibercept		Eylea	6551	5830
13	infliximab		Remicade	5908	7152
14	Pneumococcal conjugate vaccine		Prevnar 13 Prevenar 13	5802	5601
15	ustekinumab		Stelara	5156	4011
16	pregabalin	epilepsy	Lyrica	4970	5065

Largest selling pharmaceutical products of 2015

Drugs with sales above $5 billion in 2015 included:^{[3] [4]}

Rank	Drug	Trade name	Type	Main indications	Company	Sales (USD millions/year)	∆ vs 2014
1	Adalimumab	Humira	Biologic	Rheumatoid arthritis	AbbVie Inc.	14,012	1,469
2	Ledipasvir/sofosbuvir	Harvoni	Small molecule	Hepatitis C	Gilead Sciences	13,864	11,737
3	Etanercept	Enbrel	Biologic	Rheumatoid arthritis	AmgenPfizer	8,697	4,009
4	Infliximab	Remicade	Biologic	Crohn's Disease Rheumatoid Arthritis	Johnson & Johnson	8,355	1,487
5	Rituximab	MabtheraRituxan	Biologic	LymphomaLeukemia Autoimmune disorders	Roche Genentech	7,115	1,456
6	Insulin glargine	Lantus	Biologic	Diabetes mellitus	Sanofi	7,029	51
7	Bevacizumab	Avastin	Biologic	Metastatic cancers	Roche Genentech	6,751	270
8	Trastuzumab	Herceptin	Biologic	Breast cancer	Roche Genentech	6,603	265
9	Lenalidomide	Revlimid	Small molecule	Multiple myelomaMyelodysplastic syndromes	Celgene	5,801	821
10	Sofosbuvir	Sovaldi	Small molecule	Hepatitis C	Gilead Sciences	5,276	(5,007)
11	Fluticasone propionate/salmeterol	SeretideAdvair	Small molecule	AsthmaChronic obstructive pulmonary disease	GlaxoSmithKline	5,227	(778)
12	Rosuvastatin	Crestor	Small molecule	Cardiovascular diseases	AstraZeneca	5,017	(495)

Best selling pharmaceuticals of 2013

For the fourth quarter of 2013, the largest selling drugs were:^[5]

Rank	Brand Name(s)	Generic Name	Sales Q1 2014 Sales ($000)	Change from Q4 2013	Company(ies)	Disease/Medical Use	First Approval Date	Patent Expiration Date^[6] ^[7]
1	Abilify		1,602,329	2.23%		Psychosis, mania, and depression	Nov-2002	2014-Oct
2	Humira		1,561,861	3.86%		Crohn's disease; Rheumatoid arthritis	Dec-2002	2016-Dec
3	Nexium		1,536,435	0.74%		Gastrointestinal disorders	Mar-2000	2014-May
4	Crestor		1,333,502	4.53%		Cholesterol	Nov-2002	2016-Jul
5	Enbrel		1,189,844	1.46%		Rheumatoid arthritis	Nov-1998	2012-Oct
6	Advair Diskus, Seretide		1,147,330	2.65%		Asthma	Aug-2000	2012-Mar
8	Remicade		994,020	align="right"	-2.71%		Crohn's disease; rheumatoid arthritis	Aug-1998	n/a
9	Lantus Solostar		939,691	9.39%		Diabetes mellitus type 1 and 2	Apr-2000	2011-Dec
10	Neulasta		854,508	align="right"	-4.90%		Neutropenia	Jan-2002	Mon-20XX
11	Copaxone		851,351	align="right"	-4.69%		Multiple sclerosis	Dec-1996	Nov-2014
12	Rituxan, MabThera		746,766	align="right"	-0.16%		Non-Hodgkin’s lymphoma; rheumatoid arthritis	Nov-1997	Mon-20XX
13	Spiriva		726,057	3.39%		Chronic obstructive pulmonary disease	Apr-2002	2018-Jul
14	Januvia		700,941	3.63%		Diabetes mellitus type 2	Dec-1996	2017-Nov
15	Lantus		685,461	5.84%		Diabetes mellitus type 1 and 2	Apr-2000	Dec-2011
16	Atripla		679,418	0.36%		HIV infection	Dec-1996	Mar-2015
17	Cymbalta		664,186	align="right"	-23.06%		Depression; anxiety disorders	Aug-2004	Dec-2013
18	Avastin		650,208	align="right"	-1.25%		Cancer	Feb-2004	Mon-20XX
19	Lyrica		624,774	2.82%		Neuropathic pain	Jul-2004	Jul-2019
20	OxyContin		585,482	align="right"	-2.91%		Pain	Dec-1996	Mon-20XX
21	Celebrex		580,332	5.23%		Osteoarthritis; rheumatoid arthritis	Dec-1998	May-2014
22	Epogen		503,493	align="right"	-2.08%		Anemia	Jun-1989	Mon-20XX
23	Truvada		542,846	0.03%		HIV infection	Aug-2004	Mon-20XX
24	Diovan		533,924	align="right"	-2.80%		Hypertension	Dec-1996	Sep-2012
25	Levemir		424,186	9.34%		Diabetes mellitus type 1 and 2	Dec-1990	Mon-20XX
26	Gleevec, Glivec		498,149	7.22%		Leukemia	May-2001	Jan-2015
27	Herceptin		473,632	1.53%		Breast cancer	Sep-1998	Mon-20XX
28	Vyvanse		447,188	9.39%		Attention deficit hyperactivity disorder	Apr-2008	Mon-20XX
29	Lucentis		460,621	align="right"	-0.84%		Macular degeneration	Dec-1990	Mon-20XX
30	Zetia		444,731	4.04%		Cholesterol	Oct-2002	2017-Oct
31	Combivent		391,404	20.28%		Chronic obstructive pulmonary disease	Oct-1996	Mon-20XX
32	Symbicort		407,646	9.63%		Asthma	Aug-2000	Mon-20XX
33	Namenda		434,766	align="right"	-6.00%		Alzheimer's disease	Oct-2003	Apr-2014 ^[8]
34	NovoLog FlexPen		364,870	7.84%		Diabetes mellitus type 1 and 2	Oct-1996	Mon-20XX
35	Xarelto		321,462	18.72%		Oral anticoagulant	Dec-1996	Sep-2012
36	NovoLog		344,235	3.86%		Diabetes mellitus type 1 and 2	Oct-1996	Mon-20XX
37	Humalog		304,866	6.15%		Diabetes mellitus type 1 and 2	Apr-1996	Mon-20XX
38	Suboxone		321,892	align="right"	-2.11%		Pain; opioid addiction	Aug-2000	Mon-20XX
40	Viagra		300,463	3.26%		Erectile dysfunction	Mar-1998	Mar-2012
41	Seroquel XR		291,494	2.22%		Psychosis; depression	Sep-1997	Mar-2012
33	Incivo		370,899	0.00%		Hepatitis C	Dec-1990	Mon-20XX
35	AndroGel	Testosterone gel	351,737	5.47%		Low testosterone levels	Oct-2002	Oct-2016
37	Enoxaparin		341,184	6.55%		Deep-vein thrombosis	Mar-1993	2012-Aug
38	Ritalin		327,346	2.26%		Attention deficit hyperactivity disorder	Aug-2000	Mon-20XX
41	ProAir HFA		306,461	10.87%		Asthma; chronic obstructive pulmonary disease	Oct-1996	Mon-20XX
43	Alimta		302,728	6.00%		Cancer	Feb-2004	Mon-20XX
44	Victoza		301,414	9.59%		Diabetes mellitus type 2	May-1909	Mon-20XX
47	Synagis		289,704	0.00%		RSV infection	Feb-1998	Aug-2012
48	Avonex		281,554	align="right"	-1.43%		Multiple sclerosis	May-1996	Mon-20XX
49	Renvela		280,917	21.44%		Hyperphosphatemia	Apr-2002	Apr-2016 ^[9]
50	Rebif		280,548	align="right"	-6.27%		Multiple sclerosis	Feb-1998	Mon-20XX
51	Cialis		280,518	4.58%		Erectile dysfunction	Nov-2002	2017-Nov
52	Gilenya		272,701	4.05%		Multiple sclerosis	Feb-2000	2007-Jan
53	Nasonex		272,345	5.67%		Allergic rhinitis	Oct-1997	2018-Oct
54	Stelara		270,598	12.47%		Psoriasis; psoriatic arthritis	Apr-2000	Mon-20XX
55	Restasis	Ciclosporin ophthalmic emulsion	268,463	6.30%			Nov-2002	Mon-20XX
56	Budesonide		268,201	26.81%		Asthma	Aug-2000	Mon-20XX
57	Acetaminophen/hydrocodone		264,814	6.67%		Pain	Aug-2000	Mon-20XX
58	Flovent HFA		263,072	13.97%		Asthma	Mar-1996	Mon-20XX
59		Omega-3 fatty acid ethyl esters	258,177	2.90%		Cholesterol	Jun-2001	Mon-20XX
60	Prezista		251,372	3.54%		HIV infection	Jun-2006	Mon-20XX
61	Isentress		248,924	0.72%		HIV Infection	Dec-1998	Mon-20XX
62	Janumet		247,150	4.65%		Diabetes mellitus type 2	Dec-1998	Mon-20XX
63	Procrit, Eprex		241,535	align="right"	-10.09%		Anemia	Dec-1990	Mon-20XX
64	Doxycycline		241,381	align="right"	-5.65%		Bacterial infections	Dec-1996	Nov-2011
65	Orencia		241,149	1.65%		Rheumatoid arthritis	Aug-2000	Mon-20XX
66	Amphetamine/dextroamphetamine		240,482	2.78%		Attention deficit hyperactivity disorder; narcolepsy	Feb-2004	Mon-20XX
67	Vesicare		240,435	5.37%		Overactive bladder	Feb-2000	2018-Nov
68	Dexilant		238,897	7.57%		Gastrointestinal disorders	Dec-2004	Jul-2012
69	Humalog KwikPen		238,418	11.02%		Diabetes mellitus type 1 and 2	Apr-1996	Mon-20XX
70	Neupogen		229,912	align="right"	-2.70%		Neutropenia	Feb-1991	Mon-20XX
71	Lidocaine		225,903	0.00%		Pain	Mar-1999	Mon-20XX
72	Lunesta		225,101	5.24%		Insomnia	Dec-2004	April-2015
73	Fenofibrate		223,300	align="right"	-2.22%		Cholesterol	Feb-1998	Mon-20XX
74	Zytiga		222,026	11.86%		Prostate Cancer	Dec-1998	April-2015
75	Reyataz		217,793	align="right"	-1.38%		HIV infection	Jan-2003	Mon-20XX
76	Sensipar		216,657	13.71%		Hyperparathyroidism	Apr-2000	Mon-20XX
77	Metoprolol		215,111	2.99%		Hypertension	Jan-1992	Mon-20XX
78	AcipHex		214,251	10.03%		Gastrointestinal disorders	Aug-1999	Nov-2013
79	Synthroid		213,424	align="right"	-2.50%		Hypothyroidism	May-1999	Expired
80	Avonex Pen		211,917	13.59%		Hypertension	Apr-2002	Apr-2016
81	Prevnar 13		209,367	6.41%		Pneumococcal disease	Feb-2000	Jan-2007
82	Xolair		207,891	1.91%		Asthma	2003	Mon-20XX
83	Lipitor		207,542	4.23%		Cholesterol	Dec-1996	Nov-2011 ^[10]
84	levothyroxine		204,755	0.00%		Hypothyroidism	Aug-1990	Mon-20XX
85	Benicar		203,336	3.22%		Hypertension	Jun-1909	Mon-2016
86	Stribild		202,642	0.00%		HIV/AIDS	Apr-2000	Mon-20XX^[11]
87	Zostavax	Zostavax	202,240	15.17%		Herpes zoster	Aug-1999	May-2013
88	Pradaxa		200,697	align="right"	-0.53%		Oral anticoagulant	Oct-2010	Mon-20XX
89	Vytorin		199,625	align="right"	-3.02%		Cholesterol	Jul-2004	Mon-20XX
90	Tamiflu		197,718	0.00%		Influenza	Oct-1999	Mon-20XX
91	Xgeva		197,711	3.24%		Osteoporosis	Nov-2010	Mon-20XX
92	Evista		196,929	align="right"	-4.31%		Osteoporosis	Dec-1997	Jan-2013
93	Xeloda		194,044	6.52%		Cancer	Jun-1909	Mon-20XX ^[12]
94	Aranesp		185,225	align="right"	-9.22%		Anemia	Jun-2001	Mon-20XX
95	Ventolin HFA		183,060	0.00%		Asthma; chronic obstructive pulmonary disease	May-1981	Mon-20XX
96	divalproex sodium		181,554	0.00%		Epilepsy and bipolar disorder ^[13]	Jun-1909	Mon-20XX
97	Afinitor		180,719	0.03%		Cancer	Jun-1909	Mon-20XX
98	Betaseron, Betaferon		179,216	align="right"	-3.72%		Multiple sclerosis	Jul-1993	Mon-20XX
99	Adderall XR		177,505	3.31%		Attention deficit hyperactivity disorder	Oct-2001	Mon-20XX
100	Complera		174,933	0.00%		HIV	Jun-20XX	Mon-20XX

See also

• List of drugs
• Lists about the pharmaceutical industry

Notes and References

1. Web site: Medicine Spending and Affordability in the United States: Understanding Patients' Costs for Medicines. live. https://web.archive.org/web/20200917170152/https://www.iqvia.com/insights/the-iqvia-institute/reports/medicine-spending-and-affordability-in-the-us. 17 Sep 2020. IQVIA Institute for Human Data Science.
2. Web site: Top 15 Best-Selling Drugs of 2018. 2019-03-11. GEN - Genetic Engineering and Biotechnology News. en-US. 2019-05-30.
3. Web site: The Top 15 Best-Selling Drugs of 2016 . 6 March 2017 .
4. Web site: Top drugs by sales revenue in 2015: Who sold the biggest blockbuster drugs?. March 10, 2016. October 19, 2016.
5. Drugs.com U.S. Pharmaceutical Sales - Q4 2013, updated Feb. 2014
6. http://www.uspto.gov/patents/resources/terms/156.jsp Patent Terms Extended Under 35 USC §156
7. http://www.accessdata.fda.gov/scripts/cder/ob/docs/querytn.cfm Orange Book Trade Name Search
8. Web site: Unknown. Generic Namenda Availability - Drugs.com. www.drugs.com. Drugs.com. 21 December 2015.
9. Web site: Donohue. Mark. Impax Laboratories Inc. - Impax Launches Authorized Generic RENVELA®. investors.impaxlabs.com. Impax Laboratories. 21 December 2015.
10. Web site: Atorvastatin: Drug Uses, Dosage, Side Effects - Drugs.com. www.drugs.com. drugs.com. 21 December 2015.
11. Web site: HIV Treatment. www.stribild.com.
12. Web site: Walsh. Sandy. Press Announcements - FDA approves first generic capecitabine to treat colorectal and breast cancers. www.fda.gov. United States Food and Drug Administration. 21 December 2015.
13. Web site: Valproic Acid. The American Society of Health-System Pharmacists. Oct 23, 2015. live. https://web.archive.org/web/20170731065623/https://www.drugs.com/monograph/valproic-acid.html. 2017-07-31.