List of investigational sexual dysfunction drugs explained

This is a list of investigational sexual dysfunction drugs, or drugs that are currently under development for clinical treatment of sexual dysfunction but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.

This list was last comprehensively updated in June 2017. It is likely to become outdated with time.

Atrophic vaginitis

Estetrol (E4; Donesta) – estrogen receptor agonist (Estetrol - Mithra Pharmaceuticals - AdisInsight)
Lasofoxifene (CP-336156, CP-336156-CB, Fablyn, Oporia) – selective estrogen receptor modulator (Lasofoxifene - Sermonix Pharmaceuticals - AdisInsight)

Erectile dysfunction

HCP-1302 – undefined mechanism of action (HCP 1302 - AdisInsight)
Nitroglycerin gel (Eroxon, Futura, MED-2001–MED-2005) – nitric oxide donor (Nitroglycerin gel - Futura Medical - AdisInsight)
Tadalafil/tamsulosin (HCP-1303, CKD-397, YBH-1603) (Tadalafil/tamsulosin - Hanmi Pharmaceutical - AdisInsight, Tadalafil/tamsulosin - Ildong Pharmaceutical - AdisInsight, Tadalafil/tamsulosin - Chong Kun Dang - AdisInsight, Tadalafil/tamsulosin - Yungjin Pharmaceutical - AdisInsight)
TT-701 (LY-2452473) – selective androgen receptor modulator (OPK 88004 - AdisInsight)

Female anorgasmia

Testosterone low-dose intranasal (MPP-14, TBS-2, Noseafix, Tefina) – androgen receptor agonist (Testosterone intranasal (low-dose) - Acerus Pharmaceuticals - AdisInsight)

Female sexual dysfunction

BP-101 – undefined mechanism of action (BP 101 - Ovoca Bio - AdisInsight)
Bupropion/trazodone (S1P-104, S1P-205, Lorexys, Orexa) – norepinephrine reuptake inhibitor, nicotinic acetylcholine receptor antagonist, 5-HT_2A receptor antagonist, α₁-adrenergic receptor antagonist, weak serotonin reuptake inhibitor (Bupropion/trazodone - AdisInsight)
Buspirone/testosterone (Lybridos) – 5-HT_1A receptor partial agonist and androgen receptor agonist (Buspirone/testosterone - Emotional Brain - AdisInsight)
Lasofoxifene (CP-336156, CP-336156-CB, Fablyn, Oporia) – selective estrogen receptor modulator (Lasofoxifene - Sermonix Pharmaceuticals - AdisInsight)
PL-6983 – selective MC₄ receptor agonist (Research programme: sexual dysfunction therapy - Palatin Technologies - AdisInsight)
Sildenafil/testosterone (Lybrido) – PDE5 inhibitor and androgen receptor agonist (Sildenafil/testosterone - Emotional Brain - AdisInsight)
TGFK09SD – 5-HT_1A receptor agonist (TGFK 09SD - AdisInsight)

Premature ejaculation

Clomipramine/sildenafil (CDFR-0812) – serotonin reuptake inhibitor and PDE5 inhibitor (Clomipramine/sildenafil - CTC Bio - AdisInsight)
DA-8031 – serotonin reuptake inhibitor (DA 8031 - AdisInsight)
IX-01 – oxytocin receptor antagonist (Cligosiban - Ixchelsis - AdisInsight)
OnabotulinumtoxinA (botulinum toxin A, Botox) – acetylcholine release inhibitor (Onabotulinum toxin A - AbbVie - AdisInsight)

Unspecified

Vilazodone (Viibryd, EMD-68843, SB-659746A) – 5-HT_1A receptor partial agonist and serotonin reuptake inhibitor (Vilazodone - AbbVie - AdisInsight)

External links

AdisInsight - Springer