The following is a list of notable television and film personalities who made guest appearances on the Fox crime drama 21 Jump Street. Several played characters who were friends with members of the 21 Jump Street program, or were romantically linked to them, while others served as ″obstacles.″[1]
| Actor | Character | Season No. | Episode No. | Episode Title |
|---|---|---|---|---|
| Charlie | 1 | 1 | "Jump Street Chapel"/"Pilot" | |
| Brandon Douglas | Kenny Weckerle | 1 | 1 & 2 | "Jump Street Chapel"/"Pilot" |
| Reginald T. Dorsey | Tyrell "Waxer" Thompson | 1 | 1 & 2 | "Jump Street Chapel"/"Pilot" |
| Billy Jayne | Mark Dorian | 1 | 3 | "America, What a Town" |
| Steve Antin | Stevie Delano | 1 | 3 | "America, What a Town" |
| Traci Lind | Nadia | 1 | 3 | "America, What a Town" |
| Leah Ayres | Susan Chadwick | 1 | 4 | "Don't Pet the Teacher" |
| Geoffrey Blake | Jeffrey Stone | 1 | 4 | "Don't Pet the Teacher" |
| Tony Mockus, Jr. | Principal Weintraub | 1 | 4 | "Don't Pet the Teacher" |
| Josh Brolin | Taylor Rolator | 1 | 5 | "My Future's So Bright, I Gotta Wear Shades" |
| Jamie Bozian | Kurt Niles | 1 | 5 | "My Future's So Bright, I Gotta Wear Shades" |
| John D'Aquino | Vinny Morgan | 1 | 5 | "My Future's So Bright, I Gotta Wear Shades" |
| Norman Alden | Weston | 1 | 5 | "My Future's So Bright, I Gotta Wear Shades" |
| Troy Byer | Patty Blatcher | 1 | 6 | "The Worst Night of Your Life" |
| Lezlie Deane | Jane Kinney | 1 | 6 | "The Worst Night of Your Life" |
| Blair Underwood | Reginald Brooks | 1 | 7 | "Gotta Finish the Riff" |
| Robert Picardo | Ralph Buckley | 1 | 7 | "Gotta Finish the Riff" |
| Scott Schwartz | Jordan Simms | 1 | 8 | "Bad Influence" |
| Liane Curtis | Lauren Carlson | 1 | 8 | "Bad Influence" |
| Byron Thames | Dylan Taylor | 1 | 8 | "Bad Influence" |
| Sherilyn Fenn | Diane Nelson | 1 | 9 | "Blindsided" |
| Courtney Gains | Birch | 1 | 9 | "Blindsided" |
| Harold Pruett | Elly | 1 | 9 | "Blindsided" |
| Christopher Heyerdahl | Jake | 1 | 10 | "Next Generation" |
| Stephen Gregory | Hoagy Deleplant | 1 | 10 | "Next Generation" |
| Andy Romano | Tony Delaplant | 1 | 10 | "Next Generation" |
| Kurtwood Smith | Spencer Phillips | 1 | 11 | "Low and Away" |
| David Raynr | Kipling "Kip" Fuller | 1 | 12 | "16 Blown to 35" |
| Sarah G. Buxton | Trina | 1 | 12 | "16 Blown to 35" |
| Jason Priestley | Tober | 1 | 13 | "Mean Streets and Pastel Houses" |
| Actor | Character | Season No. | Episode No. | Episode Title |
|---|---|---|---|---|
| Kurtwood Smith | Spencer Phillips | 2 | 1 | "In the Custody of a Clown" |
| Ray Walston | Judge Desmond | 2 | 1 | "In the Custody of a Clown" |
| Barney Martin | Edison Coulter | 2 | 1 | "In the Custody of a Clown" |
| Jason Priestley | Brian Krompasick | 2 | 4 | "Two for the Road" |
| Pauly Shore | Kenny Ryan | 2 | 4 | "Two for the Road" |
| Reginald T. Dorsey | Tyrell "Waxer" Thompson | 2 | 9 | "You Oughta Be in Prison" |
| Shannon Tweed | Jody Kleinman | 2 | 9 | "You Oughta Be in Prison" |
| Lochlyn Munro | Derek | 2 | 9 | "You Oughta Be in Prison" |
| Mindy Cohn | Rosa | 2 | 11 | "Christmas in Saigon" |
| Kent McCord | Tom Hanson, Sr. | 2 | 14 | "Chapel of Love" |
| Mindy Cohn | Rosa | 2 | 14 | "Chapel of Love" |
| Don S. Davis | Frank | 2 | 14 | "Chapel of Love" |
| Tom Wright | Judy's Date | 2 | 14 | "Chapel of Love" |
| Jean Sagal | Betty Sue Fitzgerald | 2 | 14 | "Chapel of Love" |
| Liz Sagal | Mary Lou Fitzgerald | 2 | 14 | "Chapel of Love" |
| Deborah Lacey | Lynette Johnson | 2 | 14 | "Chapel of Love" |
| Bradford English | Charlie | 2 | 14 | "Chapel of Love" |
| Brandon Douglas | Kenny Weckerle | 2 | 15 | "I′m OK — You Need Work" |
| Christina Applegate | Tina | 2 | 15 | "I′m OK — You Need Work" |
| Peter Berg | Jerome Sawyer | 2 | 17 | "Champagne High" |
| Gabriel Jarret | Ricky | 2 | 17 | "Champagne High" |
| Bruce French | Brother Williams | 2 | 18 | "Brother Hanson & the Miracle of Renner′s Pond" |
| Dann Florek | Jim Crawford | 2 | 18 | "Brother Hanson & the Miracle of Renner′s Pond" |
| Gregory Itzin | Principal Garner | 2 | 18 | "Brother Hanson & the Miracle of Renner′s Pond" |
| Brad Pitt | Peter | 2 | 20 | "Best Years of Your Life" |
| Don S. Davis | Principal | 2 | 22 | "School′s Out" |
| Sam Anderson | Dan Finger | 2 | 22 | "School′s Out" |
| Actor | Character | Season No. | Episode No. | Episode Title |
|---|---|---|---|---|
| Leo Rossi | Sgt. Walker | 3 | 2 | "Slippin' Into Darkness" |
| Tim Russ | Ray Davies | 3 | 2 | "Slippin' Into Darkness" |
| Peri Gilpin | Fitzgerald | 3 | 3 | "The Currency We Trade In" |
| Kelly Hu | Kim Van Luy | 3 | 7 | "The Dragon and the Angel" |
| Russell Wong | Locke | 3 | 7 | "The Dragon and the Angel" |
| Christopher Titus | Jack Archer | 3 | 11 | "Woolly Bullies" |
| Dom DeLuise | Uncle Nick | 3 | 11 | "Woolly Bullies" |
| Kehli O'Byrne | Carol | 3 | 11 | "Woolly Bullies" |
| Larenz Tate | Young Adam Fuller | 3 | 11 | "Woolly Bullies" |
| Maia Brewton | Maureen Maroney | 3 | 11 | "Woolly Bullies" |
| Michael DeLuise | Doug Penhall at Age 16 | 3 | 11 | "Woolly Bullies" |
| Savannah Smith Boucher | Dr. St. John | 3 | 14 | "Nemesis" |
| Mario Van Peebles | Dana | 3 | 16 | "High High" |
| Bridget Fonda | Molly 'Moho' Chapman | 3 | 17 | "Blinded by the Thousand Points of Light" |
| Conor O'Farrell | Frank Farrell | 3 | 19 | "Loc'd Out Part 1" |
| Andrew Lauer | Psycho | 3 | 19 | "Loc'd Out Part 1" |
| Claude Brooks | Lil Monster | 3 | 19 | "Loc'd Out Part 1" |
| Conor O'Farrell | Frank Farrell | 3 | 20 | "Loc'd Out Part 2" |
| Margot Rose | D.A. Katherine Sullivan | 3 | 20 | "Loc'd Out Part 2" |
| Andrew Lauer | Psycho | 3 | 20 | "Loc'd Out Part 2" |
| Claude Brooks | Lil Monster | 3 | 20 | "Loc'd Out Part 2" |
| Actor | Character | Season No. | Episode No. | Episode Title |
|---|---|---|---|---|
| Conor O'Farrell | Frank Farrell | 4 | 1 | "Draw the Line" |
| Don S. Davis | Warden | 4 | 1 | "Draw the Line" |
| Robert Romanus | Cadet Mortellaro | 4 | 1 | "Draw the Line" |
| Rob Estes | Darryl | 4 | 2 | "Say It Ain't So, Pete" |
| Stu Nahan | Himself | 4 | 2 | "Say It Ain't So, Pete" |
| Mario Van Peebles | Dancer | 4 | 3 | "Eternal Flame" |
| Thomas Haden Church | Tony | 4 | 3 | "Eternal Flame" |
| Billy Warlock | Ron Greenwood | 4 | 4 | "Come from the Shadows" |
| Tony Plana | Robert Mendez | 4 | 4 | "Come from the Shadows" |
| Julie Warner | Alice Greenwood | 4 | 4 | "Come from the Shadows" |
| Barbara Tarbuck | Judge | 4 | 4 | "Come from the Shadows" |
| Kamala Lopez | Marta | 4 | 4 | "Come from the Shadows" |
| Pamela Adlon | Dori | 4 | 6 | "Old Haunts in a New Age" |
| Christine Elise | Quincy | 4 | 7 | "Out of Control" |
| Robyn Lively | Helen Akerly | 4 | 9 | "Mike's P.O.V." |
| Vince Vaughn | Bill Peterson | 4 | 9 | "Mike's P.O.V." |
| Mickey Jones | Bobo | 4 | 10 | "Wheels and Deals: Part 2" |
| Ray Baker | Raymond Crane | 4 | 10 | "Wheels and Deals: Part 2" |
| Keith Coogan | Kyle DeGray | 4 | 12 | "Things We Said Today" |
| Shannen Doherty | Janine DeGray | 4 | 12 | "Things We Said Today" |
| Wallace Langham | Poole | 4 | 13 | "Research and Destroy" |
| Rosie Perez | Rosie Martinez | 4 | 16 | "2245" |
| Don S. Davis | Chapman | 4 | 16 | "2245" |
| Chick Hearn | Himself | 4 | 17 | "Hi Mom" |
| Kareem Abdul-Jabbar | Wesley Williams | 4 | 17 | "Hi Mom" |
| David Raynr | Kipling 'Kip' Fuller | 4 | 17 | "Hi Mom" |
| John Waters | Mr. Bean | 4 | 18 | "Awomp-Bomp-Aloobomb, Aloop Bamboom" |
| John Pyper-Ferguson | Dealer | 4 | 18 | "Awomp-Bomp-Aloobomb, Aloop Bamboom" |
| Diedrich Bader | Paul | 4 | 20 | "Last Chance High" |
| Kelly Perine | Holt | 4 | 26 | "Blackout" |
| Kristin Dattilo | Allison | 4 | 26 | "Blackout" |
| Actor | Character | Season No. | Episode No. | Episode Title | |
|---|---|---|---|---|---|
| Jennifer Copping | Mara | 5 | 1 | "Tunnel of Love" | |
| Lisa Dean Ryan | School Girl | 5 | 2 | "Back to School" | |
| Scott Grimes | Christopher | 5 | 3 | "Buddy System" | |
| Brigitta Dau | Claire | 5 | 3 | "Buddy System" | |
| Tony Dakota | Clavo | 5 | 4 | "Poison" | |
| Perrey Reeves | Tracy Hill | 5 | 4 | "Poison" | |
| Johannah Newmarch | Lisa | 5 | 4 | "Poison" | |
| Richard Leacock | Jam | 5 | 4 | "Poison" | |
| Pat Bermel | Inspector Nickerson | 5 | 5 | "Just Say No! High" | |
| Deanna Milligan | Vanessa | 5 | 5 | "Just Say No! High" | |
| Peter Outerbridge | Jeff Chandler | 5 | 5 | "Just Say No! High" | |
| Tony Dakota | Clavo | 5 | 6 | "Poison" | |
| Don MacKay | Kyle Morgan | 5 | 6 | "Poison" | |
| John Pyper-Ferguson | Joshua, group leader | 5 | 6 | "Poison" | |
| Terence Kelly | Edward Arbogast | 5 | 7 | "This Ain't No Summer Camp" | |
| Merrilyn Gann | Rosalie Arbogast | 5 | 7 | "This Ain't No Summer Camp" | |
| Ocean Hellman | Suzanne Ross | 5 | 8 | "The Girl Next Door" | |
| Lochlyn Munro | Vince | 5 | 8 | "The Girl Next Door" | |
| Leslie Carlson | Professor Gray | 5 | 9 | "Diplomas for Sale" | |
| Tony Dakota | Clavo | 5 | 10 | "Number One with a Bullet" | |
| David DeLuise | Stevenson | 5 | 10 | "Number One with a Bullet" | |
| Kamala Lopez | Marta | 5 | 10 | "Number One with a Bullet" | |
| Sandra P. Grant | reporter | 5 | 10 | "Number One with a Bullet" | |
| Don S. Davis | Lt. Donnelly | 5 | 14 | "Film at Eleven" | |
| Jennifer Copping | Melanie | 5 | 17 | "Under the Influence" | |
| Jada Pinkett Smith | Nicole | 5 | 21 | "Homegirls" |
Mario Van Peebles also directed these episodes.