For a complete list see
The following is an incomplete list of association football clubs based in São Tomé and Príncipe.
| width=100% | Key to Divisional Change |
|---|---|
| New club | |
| Club was promoted to a higher level, winner or runner-up of each regional league qualified into the National Championships | |
| Club was transferred between divisions at the same level | |
| Club resigned or was demoted to a lower level | |
| Club was relegated to a lower level | |
| Lowest division contains only a single division |
| width=20% | Club | width=20% | Location | width=20% | League/Division (Regional) | width=3% | Lvl | width=37% | Change from 2016 |
|---|---|---|---|---|---|---|---|---|---|
| 1o de Maio | Nova Estrela | Príncipe Regional Championships | 2 | ||||||
| 6 de Setembro | Santana | São Tomé Regional Championships | 2 | ||||||
| Monte Café | São Tomé | 1 | |||||||
| FC Aliança Nacional | Pantufo | São Tomé Regional Premier Division | 2 | ||||||
| Amador | Agostinho Neto | Sāo Tomé Regional Second Division | 2 | ||||||
| Andorinha SC | Ponta Mina | São Tomé Regional Third Division | 3 | bgcolor=salmon | Relegated to the Regional Third Division | ||||
| Caixão Grande | São Tomé Regional Premier Division | 2 | |||||||
| Boavista FC de São Tome | São Tomé | São Tomé Regional Second Division | 3 | bgcolor=lightgreen | Promoted into the Regional Second Division | ||||
| CD Guadalupe | Guadalupe | Sáo Tomé Regional Second Division | 3 | ||||||
| UD Correia | São Tomé Regional Premier Division | 2 | |||||||
| Cruz Vermelha | Almeirim | São Tomé Regional Third Division | 4 | ||||||
| Desportivo Condé | São Tomé Regional Third Division | 4 | |||||||
| Desportivo Marítimo | Micolò | São Tomé Regional Third Division | 4 | bgcolor=salmon | Relegated to the Regional Second Division | ||||
| (Porto) Folha Fede | Folha Fede | São Tomé Regional Premier Division | 2 | ||||||
| Inter FC | Bom Bom | São Tomé Regional Premier Division | 2 | ||||||
| Juba Diogo Simão | Diogo Simão | São Tomé Regional Second Division | 3 | Withdrawn from competition | |||||
| Kê Morabeza | São Tomé Regional Second Division | 3 | |||||||
| FC Neves | Neves | São Tomé Regional Premier Division | 2 | ||||||
| Oque do Rei | Oque do Rei | São Tomé Regional Second Division | 3 | ||||||
| Os Operários | Santo António | Príncipe Island Championships | 2 | ||||||
| Ototó | São Tomé Regional Third Division | 4 | |||||||
| Palmar | São Tomé Regional Second Division | 3 | bgcolor=green | Promoted to the Regional Second Division | |||||
| Porto Alegre | Porto Alegre | São Tomé Regional Second Division | 4 | ||||||
| FC Porto Real | Porto Real | Príncipe Regional Championships | 2 | ||||||
| Ribeira Peixe | Ribeira Peixe | São Tomé Regional Second Division | 3 | ||||||
| Santa Margarida | São Tomé Regional Third Division | 4 | |||||||
| Santana FC | Santana | São Tomé Regional Second Division | 3 | bgcolor=salmon | Relegated to the Regional Second Division | ||||
| Sporting Príncipe | Santo António | Príncipe Island Championships | 2 | ||||||
| Sporting São Tomé | São Tomé | São Tomé Regional Second Division | 4 | bgcolor=lightgreen | Promoted to the Regional Second Division | ||||
| Sporting Praia Cruz | Praia Cruz | São Tomé Premier Division | 2 | ||||||
| GD Sundy | Santo António | Príncipe Regional Championships | 2 | ||||||
| Trindade | Trindade | São Tomé Premier Division | 2 | ||||||
| UDAPB | Picão | Príncipe Regional Championships | 2 | ||||||
| UDESCAI | Água Izé | São Tomé Premier Division | 2 | bgcolor=green | Promoted to the Regional Premier Division | ||||
| UDRA | São João dos Angolares | São Tomé Premier Division | 2 | ||||||
| Varzim FC | São Tomé Third Division | 2 | |||||||
| Diogo Vaz | Diogo Vaz | São Tomé Third Division | 2 | ||||||
| Vitória FC | Riboque | São Tomé Premier Division | 2 | ||||||