| Name | Source | Type |
|---|
| Daemonites | | |
| Sailor Moon | Purplish-skinned amorphous monsters that are forms of life native to the Tau Ceti Star System, who act as minions of the main antagonists of the third arc, the Death Busters. |
| Dakkamites | | Humanoid |
| Daktaklakpak | Star Control 3 | |
| Daleks | Doctor Who | Mutated squid-like lifeforms inside tank-like war machines. Xenophobic and power-hungry, they have repeatedly threatened the universe and are the most recurring enemies of the Doctor. |
| The Dance | | Humanoid |
| Star Wars | |
| Darjakr'Ul | Utopia | |
| Warhammer 40,000 | Humanoid pirates dedicated to sadism and depravity. |
| Darloks | Master of Orion | |
| Darrians | | |
| Darzok | | |
| Daxamites | | Humanoid |
| Futurama | Lobster people. Bright red, with tentacles over their mouths. When they mate, they die horribly. |
| | Faction of Cybertronians who are opposed to the Autobots. Ill intent for human race. |
| DearS | | Humanoid |
| | Fish-like humanoids who serve and worship the Great Old Ones known as Father Dagon and Mother Hydra. |
| | |
| Defiance | Genesis Rising | band of many different races |
| Delphons | The History of the Galaxy series | |
| Deltans | Star Trek | Humanoid |
| Delvians | Farscape | Humanoid - Similar to humans in appearance, but evolved from plants. Blue, bald, sensitive to sunlight, procreate through air-borne spores. |
| Warhammer 40,000 | |
| Deneans | Fstar trek | Humanoid |
| Denebians | Star Wars | |
| Deng | Keith Laumer's Bolo series | Arachnoids |
| Denobulans | Star Trek | Humanoid |
| Dentics | Farscape | Gastropod / Slug-like. Symbiotic relationship, used for dental hygiene purposes: This small animal thoroughly cleans the teeth of the user in a short amount of time. |
| Dentrassis | The Hitchhiker's Guide to the Galaxy | Dedicated chefs who "don't give a wet slap about anything else". |
| Pokémon | Humanoid/virus |
| Derkuhr | Chronicles of Honor | Reptilian |
| Dessarians | Tracker | |
| Detrovite | Ben 10 | |
| Star Wars | |
| Devastators | One Mind's Eye | |
| Devilukean | To Love-Ru | Humanoid |
| Dilbians | | Ursinoid |
| Dirdir | Jack Vance's Planet of Adventure Series | |
| Star Control | |
| Do Min-joon | My Love from the Star | Humanoid |
| Do Seo-joon | Oppa, Saranghae! | A humanoid character pulled out this TV show |
| Dog | | Humanoid Canine |
| Dom Kavash | Freelancer | |
| | Humanoid |
| Dominators | Doctor Who | Ruthless humanoid conquerors; served by robotic Quarks. |
| DomZ | Beyond Good & Evil | Parasitic, energy-draining creatures with a skeletal/insectoid appearance. Come in various forms, including Sarcophagii, Spirit-Eaters and the DomZ High Priest. |
| Doog | Star Control 3 | Reptiloid with canine features. Extremely dull-witted. |
| Doraemon (Parallel Planet on the contrary) | Doraemon | |
| the Doublers | Stanisław Lem's Eden | two-in-one semi-humanoid |
| Star Trek | |
| Draaknaars | Thor series | |
| Dracs | Barry B. Longyear's Enemy Mine and The Enemy Papers | Reptiloid |
| Draconians | Doctor Who | Reptilian humanoids with an interstellar empire rivalling that of Earth. |
| Draenei | World of Warcraft | Seven-foot-tall blue humanoids with cloven hooves for feet, reptilian tails, and barbels. |
| Drahvins | Doctor Who | Humanoid |
| The Longest Journey, Dreamfall | Giant dragon-like creatures. |
| Drak | Farscape | Insectile parasites |
| Babylon 5 and Crusade | Reptiloids |
| Star Frontiers | Amoeba-like meter-tall spacefaring technological species |
| Drath | Galactic Civilizations: Altarian Prophecy | Pseudo-humanoid amoebae |
| Star Trek | Humanoid |
| Dread Lords | | |
| Drej | Titan A.E. | Composed of pure energy, these aliens are a powerful force and are capable of destroying whole planets if they see fit. Ruled by a Queen. |
| Dremer | Gene Brewer's K-PAX | |
| Drengin | Galactic Civilizations | Reptiloid |
| Drones (Yanme'e) | Halo | Flying creatures, appear insectoid. Part of Covenant Hierarchy, ill intent towards humans. |
| Drophyd | Ratchet & Clank | Intelligent fish-like creatures |
| Star Control | Humanoid |
| Dubtaks | Ascendancy | large manta-like creature that move on a multitude of wormlike legs |
| Dugs | Star Wars | Reptiloids |
| Duos from Uranus | Space Patrol (1962) | Sapient semi-humanoid plants |
| Duo Miaomiao | Let's Shake It | Humanoid |
| Duo Xingxing | Let's Shake It | Humanoid |
| Durlans | | A mass of tentacles in robes. |
| Duros | Star Wars | Reptiloid |
| Peter F. Hamilton's "Pandora's Star" | | |
