List of dopaminergic drugs explained

This is a list of dopaminergic drugs. These are pharmaceutical drugs, naturally occurring compounds and other chemicals that influence the function of the neurotransmitter dopamine.

Receptor ligands

Adamantanes: Amantadine •Memantine •Rimantadine

Aminotetralins: 7-OH-DPAT •8-OH-PBZI •Rotigotine •UH-232

Benzazepines: 6-Br-APB •Fenoldopam •SKF-38,393 •SKF-77,434 •SKF-81,297 •SKF-82,958 •SKF-83,959

Ergolines: Bromocriptine •Cabergoline •Dihydroergocryptine •Lisuride •Lysergic acid diethylamide (LSD) •Pergolide

Dihydrexidine derivatives: 2-OH-NPA •A-86,929 •Ciladopa •Dihydrexidine •Dinapsoline •Dinoxyline •Doxanthrine

Others: A-68,930 •A-77,636 •A-412,997 •ABT-670 •ABT-724 •Aplindore •Apomorphine •Aripiprazole •Azodopa •Bifeprunox •BP-897 •CY-208,243 •Dizocilpine •Etilevodopa •Flibanserin •Ketamine •Melevodopa •Modafinil •Pardoprunox •Phencyclidine •PD-128,907 •PD-168,077 •PF-219,061 •Piribedil •Pramipexole •Propylnorapomorphine •Pukateine •Quinagolide •Quinelorane •Quinpirole •RDS-127 •Ro10-5824 •Ropinirole •Rotigotine •Roxindole •Salvinorin A •SKF-89,145 •Sumanirole •Terguride •Umespirone •WAY-100,635

Antagonists

Typical antipsychotics: Acepromazine •Azaperone •Benperidol •Bromperidol •Clopenthixol •Chlorpromazine •Chlorprothixene •Droperidol •Flupentixol •Fluphenazine •Fluspirilene •Haloperidol •Loxapine •Mesoridazine •Methotrimeprazine •Nemonapride •Penfluridol •Perazine •Periciazine •Perphenazine •Pimozide •Prochlorperazine •Promazine •Sulforidazine •Sulpiride •Sultopride •Thioridazine •Thiothixene •Trifluoperazine •Triflupromazine •Trifluperidol •Zuclopenthixol

Atypical antipsychotics: Amisulpride •Asenapine •Blonanserin •Cariprazine •Carpipramine •Clocapramine •Clozapine •Gevotroline •Iloperidone •Lurasidone •Melperone •Molindone •Mosapramine •Ocaperidone •Olanzapine •Paliperidone •Perospirone •Piquindone •Quetiapine •Remoxipride •Risperidone •Sertindole •Tiospirone •Ziprasidone •Zotepine

Antiemetics: AS-8112 •Alizapride •Bromopride •Clebopride •Domperidone •Metoclopramide •Thiethylperazine

Others: Amoxapine •Buspirone •Butaclamol •Ecopipam •N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) •Eticlopride •Fananserin •L-745,870 •Nafadotride •Nuciferine •PNU-99,194 •Raclopride •Sarizotan •SB-277,011-A •SCH-23,390 •SKF-83,566 •SKF-83,959 •Sonepiprazole •Spiperone •Spiroxatrine •Stepholidine •Tetrahydropalmatine •Tiapride •UH-232 •Yohimbine

Dopamine transporter (DAT) inhibitors

Piperazines: DBL-583 •GBR-12,935 •Nefazodone •Vanoxerine

Piperidines: 1-(1-(1-Benzothiophen-2-yl)cyclohexyl)piperidine (BTCP) •Desoxypipradrol •Dextromethylphenidate •Difemetorex •Ethylphenidate •Methylnaphthidate •Isopropylphenidate •Methylphenidate •Phencyclidine •Pipradrol

Pyrrolidines: Diphenylprolinol •Methylenedioxypyrovalerone (MDPV) •Naphyrone •Prolintane •Pyrovalerone

Tropanes: 3β-(4'-Chlorophenyl)-2β-(3'-phenylisoxazol-5'-yl)tropane (β-CPPIT) •Altropane •Brasofensine •WIN 35428 (β-CFT) •Cocaine •Dichloropane •Difluoropine •N-(2'-Fluoroethyl-)-3β-(4'-chlorophenyl)-2β-(3'-phenylisoxazol-5'-yl)nortropane (FE-β-CPPIT) •N-(3'-Fluoropropyl-)-3β-(4'-chlorophenyl)-2β-(3'-phenylisoxazol-5'-yl)nortropane (FP-β-CPPIT) •Ioflupane (123I) •Iometopane •RTI-112 •RTI-113 •RTI-121 •RTI-126 •RTI-150 •RTI-177 •RTI-229 •RTI-336 •Tenocyclidine •Tesofensine •Troparil •Tropoxane •2β-Propanoyl-3β-(4-tolyl)-tropane (WF-11) •2β-Propanoyl-3β-(2-naphthyl)-tropane (WF-23) •2-Propanoyl-3-(4-isopropylphenyl)-tropane (WF-31) •2α-(Propanoyl)-3β-(2-(6-methoxynaphthyl))-tropane (WF-33)

Others: Adrafinil •Armodafinil •Amfonelic acid •Amineptine •Benzatropine (benztropine) •Bromantane •2-Butyl-3-(p-tolyl)quinuclidine (BTQ) •BTS-74,398 •Bupropion (amfebutamone) •Ciclazindol •Diclofensine •Dimethocaine •Diphenylpyraline •Dizocilpine •DOV-102,677 •DOV-21,947 •DOV-216,303 •Etybenzatropine (ethylbenztropine) •EXP-561 •Fencamine •Fencamfamine •Fezolamine •GYKI-52,895 •Hydrafinil •Indatraline •Ketamine •Lefetamine •Levophacetoperane •LR-5182 •Manifaxine •Mazindol •Medifoxamine •Mesocarb •Modafinil •Nefopam •Nomifensine •NS-2359 •O-2172 •Pridefrine •Propylamphetamine •Radafaxine •SEP-225,289 •SEP-227,162 •Sertraline •Sibutramine •Tametraline •Tripelennamine

Vesicular monoamine transporter (VMAT) inhibitors (dopamine depleting agents)

Deserpidine •Deutetrabenazine •Ibogaine •Reserpine •Tetrabenazine •Valbenazine

Morpholines: Fenbutrazate •Morazone •Phendimetrazine •Phenmetrazine

Oxazolines: 4-Methylaminorex (4-MAR, 4-MAX) •Aminorex •Clominorex •Cyclazodone •Fenozolone •Fluminorex •Pemoline •Thozalinone

Phenethylamines (also amphetamines, cathinones, phentermines, etc.): 2-Hydroxyphenethylamine (2-OH-PEA) •4-Chlorophenylisobutylamine (4-CAB) •4-Methylamphetamine (4-MA) •4-Methylmethamphetamine (4-MMA) •Alfetamine •Amfecloral •Amfepentorex •Amfepramone •Amphetamine (dextroamphetamine, levoamphetamine) •Amphetaminil •β-Methylphenethylamine (β-Me-PEA) •Benzodioxolylbutanamine (BDB) •Benzodioxolylhydroxybutanamine (BOH) •Benzphetamine •Buphedrone •Butylone •Cathine •Cathinone •Clobenzorex •Clortermine •D-Deprenyl •Dimethoxyamphetamine (DMA) •Dimethoxymethamphetamine (DMMA) •Dimethylamphetamine •Dimethylcathinone (dimethylpropion, metamfepramone) •Ethcathinone (ethylpropion) •Ethylamphetamine •Ethylbenzodioxolylbutanamine (EBDB) •Ethylone •Famprofazone •Fenethylline •Fenproporex •Flephedrone •Fludorex •Furfenorex •Hordenine •Lophophine (homomyristicylamine) •Mefenorex •Mephedrone •Methamphetamine (desoxyephedrine, methedrine; dextromethamphetamine, levomethamphetamine) •Methcathinone (methylpropion) •Methedrone •Methoxymethylenedioxyamphetamine (MMDA) •Methoxymethylenedioxymethamphetamine (MMDMA) •Methylbenzodioxolylbutanamine (MBDB) •Methylenedioxyamphetamine (MDA, tenamfetamine) •Methylenedioxyethylamphetamine (MDEA) •Methylenedioxyhydroxyamphetamine (MDOH) •Methylenedioxymethamphetamine (MDMA) •Methylenedioxymethylphenethylamine (MDMPEA, homarylamine) •Methylenedioxyphenethylamine (MDPEA, homopiperonylamine) •Methylone •Ortetamine •Parabromoamphetamine (PBA) •Parachloroamphetamine (PCA) •Parafluoroamphetamine (PFA) •Parafluoromethamphetamine (PFMA) •Parahydroxyamphetamine (PHA) •Paraiodoamphetamine (PIA) •Paredrine (norpholedrine, oxamphetamine) •Phenethylamine (PEA) •Pholedrine •Phenpromethamine •Prenylamine •Propylamphetamine •Tiflorex (flutiorex) •Tyramine (TRA) •Xylopropamine •Zylofuramine

Piperazines: 2,5-Dimethoxy-4-bromobenzylpiperazine (2C-B-BZP) •Benzylpiperazine (BZP) •Methoxyphenylpiperazine (MeOPP, paraperazine) •Methylbenzylpiperazine (MBZP) •Methylenedioxybenzylpiperazine (MDBZP, piperonylpiperazine)

Others: 2-Amino-1,2-dihydronaphthalene (2-ADN) •2-Aminoindane (2-AI) •2-Aminotetralin (2-AT) •4-Benzylpiperidine (4-BP) •5-Iodo-2-aminoindane (5-IAI) •Clofenciclan •Cyclopentamine •Cypenamine •Cyprodenate •Feprosidnine •Gilutensin •Heptaminol •Hexacyclonate •Indanylaminopropane (IAP) •Indanorex •Isometheptene •Methylhexanamine •Naphthylaminopropane (NAP) •Octodrine •Phthalimidopropiophenone •Propylhexedrine (levopropylhexedrine) •Tuaminoheptane (tuamine)

Activity enhancers

Benzofuranylpropylaminopentane (BPAP) •Desmethylselegiline •Indolylpropylaminopentane (IPAP) •Phenethylamine •Phenylpropylaminopentane (PPAP) •Selegiline (L-deprenyl) •Tryptamine •Tyramine

Enzyme inhibitors

Synthesis inhibitors

Phenylalanine hydroxylase inhibitors

3,4-Dihydroxystyrene

Tyrosine hydroxylase inhibitors

3-Iodotyrosine •Aquayamycin •Bulbocapnine •Metirosine •Oudenone

Aromatic L-amino acid decarboxylase inhibitors (DOPA decarboxylase inhibitors)

Benserazide •Carbidopa •Genistein •Methyldopa

Degradation inhibitors

Nonselective: Benmoxin •Caroxazone •Echinopsidine •Furazolidone •Hydralazine •Indantadol •Iproclozide •Iproniazid •Isocarboxazid •Isoniazid •Linezolid •Mebanazine •Metfendrazine •Nialamide •Octamoxin •Paraxazone •Phenelzine •Pheniprazine •Phenoxypropazine •Pivalylbenzhydrazine •Procarbazine •Safrazine •Tranylcypromine

MAO-A selective: Amiflamine •Bazinaprine •Befloxatone •Befol •Brofaromine •Cimoxatone •Clorgiline •Esuprone •Harmala alkaloids (harmine, harmaline, tetrahydroharmine, harman, norharman, etc.) •Methylene blue •Metralindole •Minaprine •Moclobemide •Pirlindole •Sercloremine •Tetrindole •Toloxatone •Tyrima

MAO-B selective: D-Deprenyl •Selegiline (L-deprenyl) •Ladostigil •Lazabemide •Milacemide •Mofegiline •Pargyline •Rasagiline •Safinamide

Entacapone •Nitecapone •Opicapone •Tolcapone

Dopamine beta hydroxylase inhibitors

Bupicomide •Disulfiram •Dopastin •Fusaric acid •Nepicastat •Phenopicolinic acid •Tropolone

Others

Precursors

L-PhenylalanineL-tyrosineL-DOPA (levodopa)

Cofactors

Ferrous iron (Fe2+) •Tetrahydrobiopterin •Vitamin B3 (niacin, nicotinamideNADPH) •Vitamin B6 (pyridoxine, pyridoxamine, pyridoxalpyridoxal phosphate) •Vitamin B9 (folic acidtetrahydrofolic acid) •Vitamin C (ascorbic acid) •Zinc (Zn2+)

Toxins

Oxidopamine (6-hydroxydopamine)

Levodopa prodrugs

XP21279

Photoswitchable ligands

A photoswitchable agonist of D1-like receptors (azodopa) has been described that allows reversible control of dopaminergic transmission in wildtype animals.