Here is a list of cities and towns in São Tomé and Príncipe. These are villages, towns, and cities with populations over 300. The date of censuses are August 4, 1991, August 25, 2001, and January 1, 2005:
| Rank | Place | Population | District | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Census 1991 | Census 2001 | Estimate 2005 | ||||||||
| align=right | 1. | São Tomé (capital) | align=right | 42,331 | align=right | 49,957 | align=right | 56,166 | Água Grande | |
| align=right | 2. | align=right | 5,878 | align=right | - | align=right | 8,239 | Lobata | ||
| align=right | 3. | align=right | 5,919 | align=right | 6,635 | align=right | 7,392 | Lembá | ||
| align=right | 4. | align=right | 6,190 | align=right | 6,228 | align=right | 6,969 | Cantagalo | ||
| align=right | 5. | align=right | - | align=right | 6,049 | align=right | 6,636 | Mé-Zóchi | ||
| align=right | 6. | align=right | - | align=right | 1,862 | align=right | 2,045 | Caué | ||
| align=right | 7. | align=right | - | align=right | 1,929 | align=right | 2,169 | Água Grande | ||
| align=right | 8. | align=right | - | align=right | 1,543 | align=right | 1,734 | Lobata | ||
| align=right | 9. | align=right | 1,000 | align=right | 1,010 | align=right | 1,156 | Pagué | ||
| align=right | 10. | align=right | - | align=right | - | align=right | 971 | Lembá | ||
| align=right | 11. | align=right | - | align=right | - | align=right | 334 | Caué | ||