The show has received multiple award nominations. It has been nominated for 46 Primetime Emmy Awards (winning six technical awards, one for Kathy Bates for Outstanding Guest Actress in a Comedy Series as The Ghost of Charlie Harper, and two for Jon Cryer as Alan Harper), and has also received two Golden Globe Award nominations for Charlie Sheen for Best Actor in a Television Series – Musical or Comedy. The show won the award for Favorite TV Comedy at the 35th People's Choice Awards.
| Year | Category | Nominee | Result |
|---|
| 2004 | Outstanding Original Main Title Theme Music | Lee Aronsohn, Grant Geissman, Chuck Lorre | |
| Outstanding Cinematography for a Multi-Camera Series | Steven V. Silver (for "Camel Filters and Pheremones") | |
| Outstanding Art Direction for a Multi-Camera Series | John Shaffner, Ann Shea (for "Alan Harper, Frontier Chiropractor") | |
| 2005 | Outstanding Supporting Actress in a Comedy Series | Holland Taylor (as "Evelyn Harper") | |
| Outstanding Supporting Actress in a Comedy Series | Conchata Ferrell (as "Berta") | |
| Outstanding Multi-Camera Sound Mixing for a Series or Special | Bob La Masney, Charlie McDaniel, Kathy Oldham, Bruce Peters (for "Can You Eat Human Flesh with Wooden Teeth?") | |
| Outstanding Multi-Camera Picture Editing for a Series | Joe Bella (for "It Was Mame, Mom") | |
| Outstanding Cinematography for a Multi-Camera Series | Steven Silver (for "Back Off, Mary Poppins") | |
| Outstanding Art Direction for a Multi-Camera Series | John Shaffner, Ann Shea (for "It Was 'Mame', Mom"/"A Low, Guttural Tongue Flapping Noise") | |
| 2006 | Outstanding Supporting Actor in a Comedy Series | Jon Cryer (as "Alan Harper") | |
| Outstanding Multi-Camera Sound Mixing for a Series or Special | Bob La Masney, Charlie McDaniel, Kathy Oldham, Bruce Peters (for "The Unfortunate Little Schnauzer") | |
| Outstanding Multi-Camera Picture Editing for a Series | Joe Bella (for "That Special Tug") | |
| Outstanding Lead Actor in a Comedy Series | Charlie Sheen (as "Charlie Harper") | |
| Outstanding Guest Actor in a Comedy Series | Martin Sheen (as "Harvey") | |
| Outstanding Comedy Series | Lee Aronsohn, Mark Burg, Oren Koules, Chuck Lorre, Eric Tannenbaum and Kim Tannenbaum, executive producers; Susan Beavers, Don Foster and Eddie Gorodetsky, co-executive producers; Mark Roberts, supervising producers; Michael Collier, produced by | |
| Outstanding Cinematography for a Multi-Camera Series | Steven V. Silver (for "Carpet Burns and a Bite Mark") | |
| 2007 | Outstanding Supporting Actress in a Comedy Series | Holland Taylor (as "Evelyn Harper") | |
| Outstanding Supporting Actress in a Comedy Series | Conchata Ferrell (as "Berta") | |
| Outstanding Supporting Actor in a Comedy Series | Jon Cryer (as "Alan Harper") | |
| Outstanding Multi-Camera Picture Editing for a Series | Joe Bella (for "Release the Dogs") | |
| Outstanding Lead Actor in a Comedy Series | Charlie Sheen (as "Charlie Harper") | |
| Outstanding Comedy Series | Chuck Lorre, Lee Aronsohn, Eric Tannenbaum, Kim Tannenbaum, Mark Burg and Oren Koules, executive producers; Don Foster, Eddie Gorodetsky, Susan Beavers and Mark Roberts, co-executive producers; Michael Collier and Jim Patterson, producers | |
| Outstanding Cinematography for a Multi-Camera Series | Steven Silver (for "Release the Dogs") | |
| 2008 | Outstanding Supporting Actress in a Comedy Series | Holland Taylor (as "Evelyn Harper") | |
| Outstanding Supporting Actor in a Comedy Series | Jon Cryer (as "Alan Harper") | |
| Outstanding Sound Mixing for a Comedy or Drama Series (half-hour) and Animation | Bruce Peters, Kathy Oldham, Charlie McDaniel, Bob La Masney (for "Is There a Mrs. Waffles?") | |
| Outstanding Makeup for a Multi-Camera Series or a Special (non-prosthetic) | Janice Berridge, Peggy Nichols, Shelly Woodhouse-Collins, Gabriel Solana (for "City of Great Racks") | |
| Outstanding Lead Actor in a Comedy Series | Charlie Sheen (as "Charlie Harper") | |
| Outstanding Hairstyling for a Multi-Camera Series or a Special | Pixie Schwartz, Krista Borrelli, Ralph M. Abalos, Janice Zoladz (for "City of Great Racks") | |
| Outstanding Comedy Series | Chuck Lorre, Lee Aronsohn, Eric Tannenbaum, Kim Tannenbaum, Mark Burg and Oren Koules, executive producers; Don Foster, Eddie Gorodetsky, Susan Beavers and Mark Roberts, co-executive producers; Jim Patterson, producer; Michael Collier, produced by | |
| 2009 | Outstanding Supporting Actor in a Comedy Series | Jon Cryer (as "Alan Harper") | |
| Outstanding Lead Actor in a Comedy Series | Charlie Sheen (as "Charlie Harper") | |
| 2010 | Outstanding Supporting Actor in a Comedy Series | Jon Cryer (as "Alan Harper") | |
| Outstanding Supporting Actress in a Comedy Series | Holland Taylor (as "Evelyn Harper") | |
| Outstanding Guest Actress in a Comedy Series | Jane Lynch (as "Dr. Linda Freeman") | |
| Outstanding Cinematography for a Half-Hour Series | Steven V. Silver (for "Crude and Uncalled For") | |
| Outstanding Hairstyling for a Multi-Camera Series or Special | Pixie Schwartz, Krista Borrelli, Ralph Abalos, Janice Allison (for "That's Why They Call It Ballroom") | |
| Outstanding Sound Mixing for a Comedy or Drama Series (Half-Hour) and Animation | Bruce Peters, Bob LaMasney, Kathy Oldham (for "Fart Jokes, Pie and Celeste") | |
| 2011 | Outstanding Supporting Actor in a Comedy Series | Jon Cryer (as "Alan Harper") | |
| Outstanding Cinematography for a Multi-Camera Series | Steven V. Silver (for "Hookers, Hookers, Hookers") | |
| 2012 | Outstanding Lead Actor in a Comedy Series | Jon Cryer (as "Alan Harper") | |
| Outstanding Cinematography for a Multi-Camera Series | Steven V. Silver (for "Sips, Sonnets and Sodomy") | |
| Outstanding Multi-Camera Picture Editing for a Comedy Series | Joseph Bella (for "Why We Gave Up Women") | |
| Outstanding Guest Actress in a Comedy Series | Kathy Bates (as "Charlie Harper") | |
| 2013 | Outstanding Cinematography for a Multi-Camera Series | Steven V. Silver (for "Grab a Feather and Get in Line") | |
| Outstanding Art Direction for a Multi-Camera Series | John Schaffner, Ann Shea, Francoise Cherry-Cohen (for "Avoid the Chinese Mustard") | | |
