| Year | Category | Nominee(s) | Episode | Result |
|---|
| 2000 | Outstanding Directing for a Comedy Series | Todd Holland | "Pilot" | |
| Outstanding Lead Actress in a Comedy Series | Jane Kaczmarek | "Red Dress" | |
| Outstanding Guest Actress in a Comedy Series | Bea Arthur | "Water Park" | |
| Outstanding Writing for a Comedy Series | Linwood Boomer | "Pilot" | |
| Outstanding Casting for a Comedy Series | Ken Miller, Mary V. Buck, Nikki Valko, Susan Edelman | | |
| 2001 | Outstanding Comedy Series | Linwood Boomer, Bob Stevens, Gary Murphy, Neil Thompson, Alan J. Higgins, Michael Glouberman, Andrew Orenstein, Todd Holland, Alex Reid, James Simons, Ken Kwapis, Jeff Melman | | |
| Outstanding Directing for a Comedy Series | Todd Holland | "Bowling" | |
| Jeff Melman | "Flashback" | |
| Outstanding Lead Actor in a Comedy Series | Frankie Muniz | "Bowling" | |
| Outstanding Lead Actress in a Comedy Series | Jane Kaczmarek | "Flashback" | |
| Outstanding Guest Actor in a Comedy Series | Robert Loggia | "Grandparents" | |
| Outstanding Guest Actress in a Comedy Series | Cloris Leachman | "Grandparents" | |
| Outstanding Writing for a Comedy Series | Alex Reid | "Bowling" | |
| 2002 | Outstanding Directing for a Comedy Series | Jeff Melman | "Christmas" | |
| Outstanding Lead Actress in a Comedy Series | Jane Kaczmarek | "Poker" | |
| Outstanding Supporting Actor in a Comedy Series | Bryan Cranston | "Poker" / "Monkey" | |
| Outstanding Guest Actress in a Comedy Series | Cloris Leachman | "Christmas" | |
| Susan Sarandon | "Company Picnic" | |
| Outstanding Stunt Coordination | Bobby Porter | "Company Picnic" | |
| 2003 | Outstanding Lead Actress in a Comedy Series | Jane Kaczmarek | "Baby" | |
| Outstanding Supporting Actor in a Comedy Series | Bryan Cranston | "Malcolm Holds His Tongue" / "Day Care" | |
| Outstanding Guest Actress in a Comedy Series | Cloris Leachman | | |
| Outstanding Single Camera Picture Editing for a Comedy Series | Mark Scheib, Steve Welch | "If Boys Were Girls" | |
| 2004 | Outstanding Lead Actress in a Comedy Series | Jane Kaczmarek | "Block Party" | |
| Outstanding Guest Actress in a Comedy Series | Cloris Leachman | | |
| Outstanding Choreography | Fred Tallaksen | "Dewey's Special Class" | |
| 2005 | Outstanding Lead Actress in a Comedy Series | Jane Kaczmarek | "Lois Battles Jamie" | |
| Outstanding Guest Actress in a Comedy Series | Cloris Leachman | | |
| Outstanding Music and Lyrics | Charles Sydnor, Eric Kaplan | "Song: "The Married Bed"
Episode: "Dewey's Opera" | |
| 2006 | Outstanding Lead Actress in a Comedy Series | Jane Kaczmarek | "Lois Strikes Back" | |
| Outstanding Supporting Actor in a Comedy Series | Bryan Cranston | "College Recruiters" / "Hal Grieves" | |
| Outstanding Guest Actress in a Comedy Series | Cloris Leachman | | |
| Outstanding Choreography | Fred Tallaksen | "Bomb Shelter" | | |
| Year | Category | Nominee(s) | Result |
|---|
| 2001 | Best Performance in a TV Comedy Series - Leading Young Actor | Frankie Muniz | |
| Best Performance in a TV Comedy Series - Supporting Young Actor | Craig Lamar Traylor | |
| Best Performance in a TV Comedy Series - Guest Starring Young Performer | Ashley Edner | |
| Best Performance in a TV Series (Comedy or Drama) - Young Actor Age Ten or Under | Erik Per Sullivan | |
| Best Ensemble in a TV Series (Drama or Comedy) | Frankie Muniz, Justin Berfield, Erik Per Sullivan, Craig Lamar Traylor, Christopher Masterson | |
| 2002 | Best Family TV Comedy Series | – | |
| Best Performance in a TV Comedy Series - Leading Young Actor | Frankie Muniz | |
| Best Performance in a TV Comedy Series - Supporting Young Actor | Craig Lamar Traylor | |
| Best Performance in a TV Comedy Series - Guest Starring Young Actor | Bobby Brewer | |
| Best Performance in a TV Comedy Series - Guest Starring Young Actress | Brooke Anne Smith | |
| Best Performance in a TV Series (Comedy or Drama) - Young Actor Age Ten or Under | Erik Per Sullivan | |
| Best Ensemble in a TV Series (Drama or Comedy) | Frankie Muniz, Justin Berfield, Erik Per Sullivan, Craig Lamar Traylor, Christopher Masterson | |
| 2003 | Best Performance in a TV Series (Comedy or Drama) - Leading Young Actor | Frankie Muniz | |
| Best Performance in a TV Series (Comedy or Drama) - Supporting Young Actor | Justin Berfield | |
| Best Performance in a TV Comedy Series - Guest Starring Young Actor | Miles Marsico | |
| Best Performance in a TV Comedy Series - Guest Starring Young Actress | Lauren Storm | |
| Best Ensemble in a TV Series (Comedy or Drama) | Frankie Muniz, Justin Berfield, Erik Per Sullivan, Kyle Sullivan, Craig Lamar Traylor | |
| 2004 | Most Popular Mom & Pop in a Television Series | Jane Kaczmarek, Bryan Cranston | |
| 2005 | Best Performance in a Television Series - Recurring Young Actor | Cameron Monaghan | | |
