List of antiviral drugs explained

Antiviral drugs are different from antibiotics. Flu antiviral drugs are different from antiviral drugs used to treat other infectious diseases such as COVID-19. Antiviral drugs prescribed to treat COVID-19 are not approved or authorized to treat flu.^[1]

List of Antiviral Drugs!Antiviral!Use!Manufacturer!Component!Type!Year approved

Abacavir	HIV	ViiV Healthcare		Nucleoside analogue reverse transcriptase inhibitor (NRTI)	1998
Acyclovir (Aciclovir)	Herpes Simplex, chickenpox,^[2] varicella zoster virus			guanosine analogue RTI	1981
Adefovir	Hepatitis B^[3]	Gilead Sciences		RTI	2002 (FDA), 2003 (EU)
Amantadine	Influenza			Influenza A virus M2 proton channel antagonist
Ampligen	Avian Influenza
Amprenavir (Agenerase)	HIV			Protease inhibitor (PI)
Umifenovir (Arbidol)	Influenza			Hemagglutinin inhibitor
Atazanavir	HIV			PI
Atripla (Efavirenz/emtricitabine/tenofovir)	HIV			Efavirenz: Non-nucleoside RTI (NNRTI) Emtricitabine: NRTI Tenofovir disoproxil: NRTI
Baloxavir marboxil (Xofluza)^[4]	Influenza A/B			Cap snatching endonuclease inhibitor	2018
Biktarvy (Bictegravir/emtricitabine/tenofovir alafenamide)	HIV			Bictegravir: INSTI Emtricitabine: NRTI Tenofovir alafenamide: NRTI
Boceprevir	Hepatitis C genotype 1^[5]	Schering-Plough, then Merck Group		Protease inhibitor	FDA approved 2011 Withdrawn 2015
Bulevirtide	Hepatitis D/B			Sodium/bile acid cotransporter inactivator
Cidofovir	AIDS			Viral DNA Polymerase inhibitor
Cobicistat (Tybost)^[6]	HIV			human CYP3A protein inhibitor
Combivir (Lamivudine/Zidovudine)	HIV			Lamivudine: cytidine analogue RTI Zidovudine: thymidine analogue RTI
Daclatasvir (Daklinza)	Hepatitis C			NS5A inhibitor
Darunavir	HIV		antiretroviral	HIV PI
Delavirdine	HIV		antiretroviral	NNRTI
Descovy (Emtricitabine/tenofovir alafenamide)	Hepatitis B			Emtricitabine: NRTI Tenofovir alafenamide: NRTI
Didanosine	HIV			Adenosine analogue RTI
Docosanol	Herpes Simplex			Entry inhibitor
Dolutegravir	HIV			Integrase inhibitor
Doravirine (Pifeltro)^[7]	HIV			NNRTI
Edoxudine	Herpes Simplex			Thymidine analogue inhibitor
Efavirenz	HIV	Mylan		NNRTI	1998
Elvitegravir	HIV	Gilead Sciences		Integrase inhibitor	2012 (Fixed-dose combo Stribild) 2014 (single pill) 2015 (Genvoya)
Emtricitabine	HIV	Gilead Sciences		NRTI	2003
Enfuvirtide	HIV			Entry inhibitor	2003
Ensitrelvir	COVID-19	Shionogi		3C-like protease inhibitor
Entecavir	HIV			NRTI	2005
Etravirine (Intelence)^[8]	HIV			NNRTI	2008
Famciclovir	Herpes Zoster			Guanosine analogue	1994
Fomivirsen	AIDS		Anti-sense oligonucleotide	Anti-sense	FDA-licensed in 1998 Withdrawn in EU (2002), US (2006)
Fosamprenavir	HIV	ViiV Healthcare		Amprenavir pro-drug	2003 (FDA), 2004 (EMA)
Foscarnet	Herpes			Pyrophosphate analogue DNA polymerase inhibitor	1991
Ganciclovir (Cytovene)^[9]	Cytomegalovirus (CMV)^[10]			Competitive nucleoside analogue dGTP inhibitor	1988
Ibacitabine	Herpes labialis
Ibalizumab (Trogarzo)^[11]	HIV			Entry inhibitor	2018
Idoxuridine	Herpes			dU analogue inhibitor	1962
Imiquimod	Genital wart, Basal cell carcinoma, Actinic keratosis			Opioid growth factor receptor (OGFr) agonist	1997
Inosine pranobex	Herpes Simplex			Thymus hormone immunostimulant
Indinavir	HIV			PI	1996
Lamivudine	HIV			cytidine analogue RTI
Letermovir (Prevymis)^[12]	Cytomegalovirus (CMV)
Lopinavir	HIV
Loviride	HIV
Maraviroc	HIV			entry inhibitor
Methisazone	Smallpox
Molnupiravir	COVID-19			viral RNA polymerase inhibitor
Moroxydine	Influenza
Nelfinavir	HIV
Nirmatrelvir/ritonavir (Paxlovid)	COVID-19	Pfizer		3C-like protease inhibitor (Nirmatrelvir) / inhibition of metabolism of nirmatrelvir (ritonavir)
Nevirapine	HIV			non-nucleoside reverse transcriptase inhibitor
Nitazoxanide	Broad-spectrum antiviral		thiazolide
Norvir	HIV
Oseltamivir (Tamiflu)^[13]	Influenza			neuraminidase inhibitor
Peramivir (Rapivab)^[14]	Influenza
Penciclovir	Herpes
Pleconaril	Picornavirus	Schering-Plough
Podophyllotoxin	Genital wart
Raltegravir	HIV			Integrase inhibitor
Remdesivir	COVID-19			viral RNA polymerase inhibitor
Ribavirin	Hepatitis C^[15]			nucleoside analogue reverse transcriptase inhibitor
Rilpivirine (Edurant)^[16]	HIV
Rimantadine	Influenza A			M2 proton channel antagonist
Ritonavir	HIV			HIV-1 protease inhibitor
Saquinavir	HIV
Simeprevir (Olysio)	Hepatitis C
Sofosbuvir	Hepatitis C^[17]			nucleoside analogue reverse transcriptase inhibitor
Stavudine	HIV
Taribavirin (Viramidine)	Hepatitis Syndromes in which Ribavirin is active^[18]
Telaprevir	Hepatitis C
Telbivudine (Tyzeka)	Hepatitis B
Tenofovir alafenamide	Hepatitis B
Tenofovir disoproxil	Hepatitis B, HIV^[19]
Tipranavir	HIV
Trifluridine	Eyes related Herpes
Trizivir	HIV
Tromantadine	Herpes Simplex
Truvada	HIV
Umifenovir	Influenza
Valaciclovir (Valtrex)^[20]	Herpes Simplex/Zoster
Valganciclovir (Valcyte)^[21]	Cytomegalovirus (CMV)
Vicriviroc	HIV-1	Schering-Plough		pyrimidine CCR5 entry inhibitor
Vidarabine	Herpes Simplex, Varicella Zoster
Zalcitabine	HIV
Zanamivir (Relenza)^[22]	Influenza A, Influenza B
Zidovudine	HIV^[23]		Antiretroviral

Notes and References

1. Web site: What You Should Know about Flu Antiviral Drugs . 15 December 2022 .
2. Web site: Acyclovir. The American Society of Health-System Pharmacists. Jan 1, 2015. live. https://web.archive.org/web/20150105113809/http://www.drugs.com/monograph/acyclovir.html. 2015-01-05.
3. Marcellin P, Chang TT, Lim SG, Tong MJ, Sievert W, Shiffman ML, Jeffers L, Goodman Z, Wulfsohn MS, Xiong S, Fry J, Brosgart CL . 6 . Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B . The New England Journal of Medicine . 348 . 9 . 808–16 . February 2003 . 12606735 . 10.1056/NEJMoa020681 . free .
4. Web site: Xofluza- baloxavir marboxil tablet, film coated . DailyMed . 28 October 2019 . 21 September 2020.
5. Degertekin B, Lok AS (May 2008). "Update on viral hepatitis: 2007". Curr. Opin. Gastroenterol. 24 (3): 306–11. doi:10.1097/MOG.0b013e3282f70285. . S2CID 43762307
6. Web site: Tybost- cobicistat tablet, film coated . DailyMed . 27 August 2020 . 21 September 2020.
7. Web site: Pifeltro- doravirine tablet, film coated . DailyMed . 10 October 2019 . 21 September 2020.
8. Web site: Intelence- etravirine tablet . DailyMed . 9 June 2020 . 21 September 2020.
9. Web site: Cytovene IV- ganciclovir sodium injection, powder, lyophilized, for solution . DailyMed . 19 June 2020 . 21 September 2020.
10. Rossi S, editor. Australian Medicines Handbook 2006. Adelaide: Australian Medicines Handbook; 2006.
11. Web site: Trogarzo- ibalizumab injection, solution . DailyMed . 8 April 2020 . 21 September 2020.
12. Web site: Prevymis- letermovir tablet, film coated PREVYMIS- letermovir injection, solution . DailyMed . 23 March 2020 . 21 September 2020.
13. Web site: Tamiflu- oseltamivir phosphate capsule TAMIFLU- oseltamivir phosphate powder, for suspension . DailyMed . 21 September 2020.
14. Web site: Rapivab- peramivir solution . DailyMed . 3 August 2020 . 21 September 2020.
15. "Rebetol, Ribasphere (ribavirin) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Archived from the original on 28 February 2014. Retrieved 23 February 2014.
16. Web site: Edurant- rilpivirine hydrochloride tablet, film coated . DailyMed . 8 June 2020 . 21 September 2020.
17. Berden FA, Kievit W, Baak LC, Bakker CM, Beuers U, Boucher CA, Brouwer JT, Burger DM, van Erpecum KJ, van Hoek B, Hoepelman AI, Honkoop P, Kerbert-Dreteler MJ, de Knegt RJ, Koek GH, van Nieuwkerk CM, van Soest H, Tan AC, Vrolijk JM, Drenth JP . Dutch guidance for the treatment of chronic hepatitis C virus infection in a new therapeutic era . The Netherlands Journal of Medicine . 72 . 8 . 388–400 . October 2014 . 25387551 .
18. Gish RG (January 2006). "Treating HCV with ribavirin analogues and ribavirin-like molecules". The Journal of Antimicrobial Chemotherapy. 57 (1): 8–13. doi:10.1093/jac/dki405.
19. "Tenofovir Disoproxil Fumarate". The American Society of Health-System Pharmacists. Archived from the original on 30 November 2016. Retrieved 29 November 2016.
20. Web site: Valtrex- valacyclovir hydrochloride tablet, film coated . DailyMed . 10 December 2019 . 21 September 2020.
21. Web site: Valcyte- valganciclovir tablet, film coated VALCYTE- valganciclovir hydrochloride powder, for solution . DailyMed . 9 August 2018 . 3 September 2022.
22. Web site: Relenza- zanamivir powder . DailyMed . 21 June 2018 . 21 September 2020.
23. Web site: Zidovudine . PubChem Public Chemical Database . NCBI . April 10, 2011 . live . https://web.archive.org/web/20121025081252/http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=35370 . October 25, 2012 .