| Post: | Ambassador of Spain to the Holy See |
| Insignia: | Escudo de España (mazonado).svg |
| Insigniasize: | 120px |
| Insigniacaption: | Coat of Arms of Spain |
| Department: | Ministry of Foreign Affairs |
| Incumbent: | María Isabel Celáa Diéguez |
| Incumbentsince: | 26 January 2022 |
| Style: | Her Excellency |
| Nominator: | Minister of Foreign Affairs |
| Appointer: | His Royal Majesty King Felipe VI |
| Deputy: | Deputy Chief of Mission at the Embassy of Spain to the Holy See |
The Ambassador of Spain to the Holy See is the Kingdom of Spain's foremost diplomatic representative in the Holy See.
The ambassador is appointed to the Council of Ministers, they direct the work of all the offices that depend on the Embassy, based in Vatican City. Likewise, it informs the Spanish Government about the evolution of events in the Holy See, negotiates on behalf of Spain, can sign or ratify agreements, observes the development of bilateral relations in all fields and ensures the protection of Spanish interests and its citizens in the Holy See.
The current ambassador is María Isabel Celáa Diéguez, who was appointed by Pedro Sánchez's government on 26 January 2022.[1]
| align=center valign=bottom width="10%" | Mission Start | align=center valign=bottom width="10%" | Mission End | align=center valign=bottom width="40%" | Name | valign=bottom width="40%" | Notes |
|---|---|---|---|---|---|---|---|
| 1475 | 1475 | Gonzalo Fernández de Heredia | |||||
| 1482 | 1484 | Gonzalo de Beteta | |||||
| 1485 | 1487 | Íñigo López de Mendoza, Count of Tendilla | |||||
| 1488 | 1491 | Francisco de Rojas y Escobar | |||||
| 1494 | 1499 | Garcilaso de la Vega, Señor de los Arcos | |||||
| 1498 | 1507 | Francisco de Rojas y Escobar | |||||
| 1507 | 1520 | Jerónimo Vich y Valterra | |||||
| 1520 | 1522 | Juan Manuel, señor de Belmonte | |||||
| 1522 | 1526 | Luis Fernández de Córdoba y Zúñiga | |||||
| 1537 | 1540 | Juan Fernández Manrique de Lara, Marquess of Aguilar de Campoo | |||||
| 1558 | 1558 | Pedro Téllez-Girón y de la Cueva, Count of Ureña | |||||
| 1561 | 1562 | Luis de Zúñiga y Requesens | |||||
| 1566 | 1566 | Luis Fernández-Manrique de Lara, Marquess of Aguilar de Campoo | Ambassador Extraordinary sent by Philip II to congratulate Pope Pius V on the his election. | ||||
| 1566 | 1571 | Antonio Perrenot de Granvela | |||||
| 1587 | 1587 | Enrique de Guzmán y Ribera, 2nd Count of Olivares | |||||
| 1588 | 1598 | Juan Vich y Manrique de Lara | |||||
| 1616 | 1619 | Gaspar de Borja y Velasco | Again ambassador from 1631 to 1634. | ||||
| 1619 | 1623 | Francisco Fernández de la Cueva, 7th Duke of Alburquerque | |||||
| 1623 | 1626 | Ruy III Gómez de Silva y Mendoza, 3rd Duke of Pastrana | |||||
| 1625 | 1626 | Fernando Afán de Ribera y Téllez-Girón, 3rd Duke of Alcalá | Extraordinary appointed by Philip IV | ||||
| 1626 | 1628 | Íñigo Vélez de Guevara y Tassis, 7th Count of Oñate | |||||
| 1628 | 1631 | Manuel de Acevedo y Zúñiga, 6th Count of Monterrey | |||||
| 1631 | 1631 | Diego de Saavedra Fajardo | |||||
| 1632 | 1644 | Manuel de Moura y Corte-Real, 2nd Marquess of Castel-Rodrigo | [2] | ||||
| 1633 | 1637 | Domingo Pimentel | Ambassadors sent by Philip IV to protest against the damages that Spain received from Rome.[3] | ||||
| 1633 | 1643 | Juan Chumacero Carrillo y Sotomayor | |||||
| 1691 | 1698 | Luis Francisco de la Cerda, 4th Duke of Medinaceli | |||||
| 1699 | 1709 | Juan Francisco Pacheco Téllez-Girón, Duke of Uceda | |||||
| 1708 | 1714 | Hercule-Louis Turinetti | |||||
| 1717 | 1725 | Francesco Acquaviva d'Aragona | |||||
| 1726 | 1732 | Marco Cornelio Bentivoglio | [4] | ||||
| 1732 | 1734 | Luis Antonio de Belluga y Moncada | |||||
| 1735 | 1747 | [5] | |||||
| 1747 | 1748 | Alfonso Clemente de Aróstegui | |||||
| 1748 | 1760 | Joaquín Fernández Portocarrero | [6] | ||||
| 1760 | 1765 | Manuel de Roda y Arrieta | |||||
| 1765 | 1772 | Tomás Aspurruo | |||||
| 1772 | 1776 | José Moñino y Redondo, Conde de Floridablanca | |||||
| 1777 | 1784 | Jerónimo Grimaldi, Marquess of Grimaldi | |||||
| 1784 | 1798 | José Nicolás de Azara | |||||
| 1801 | 1809 | Antonio Vargas Laguna | |||||
| 1847 | [7] | ||||||
| 1847 | Francisco Martínez de la Rosa | ||||||
| 1859 | [8] | ||||||
| 1861 | Manuel Pando Fernández de Pinedo | [9] | |||||
| 1864 | Gerardo de Souza | ||||||
| 1864 | [10] | ||||||
| 1864 | 1866 | Francisco Javier de Istúriz | |||||
| 1866 | 1867 | Luis José Sartorius y Tapia | |||||
| 1867 | 1868 | Alejandro de Castro y Casal | |||||
| 1868 | 1869 | José Posada Herrera | [11] [12] | ||||
| 1870 | 1876 | Viscount of Oña | |||||
| 1875 | Juan Álvarez de Lorenzana, Viscount of Barrantes | [13] | |||||
| 1875 | 1875 | Antonio Benavides Fernández de Navarrete | [14] [15] | ||||
| 1876 | 1881 | Francisco de Cárdenas | |||||
| 1881 | 1884 | Alejandro Groizard y Gómez de la Serna | [16] | ||||
| 1884 | 1886 | Mariano Roca de Togores, Marquess of Molins | [17] [18] | ||||
| 1893 | 1901 | Rafael Carlos Merry del Val | |||||
| 1901 | 1902 | Alejandro Pidal y Mon | |||||
| 1902 | 1904 | José Gutiérrez de Agüera | |||||
| 1904 | 1904 | Luis Polo de Bernabé Pilón | |||||
| 1904 | 1905 | Manuel Aguirre de Tejada | |||||
| 1905 | 1906 | Rodrigo de Figueroa y Torres | |||||
| 1906 | 1911 | Emilio de Ojeda y Perpiñán | |||||
| 1913 | 1913 | Fermín Calbetón y Blanchon | [19] | ||||
| 1913 | 1916 | Cipriano Muñoz y Manzano, Count of the Viñaza | |||||
| 1916 | 1917 | Fermín Calbetón y Blanchon | [20] | ||||
| 1922 | 1922 | Wenceslao Ramírez de Villa-Urrutia, 1st Marquis of Villa-Urrutia | |||||
| 1923 | Diego Atienza de Reinosa | [21] | |||||
| 1926 | 1930 | Antonio Magaz y Pers, 2nd Marquess of Magaz. | |||||
| 1930 | 1931 | Emilio de Palacios y Fau | |||||
| 1931 | 1934 | Eduardo García Comin | [22] | ||||
| 1934 | 1936 | Leandro Pita Romero | |||||
| 1936 | 1938 | Luis de Zulueta y Escolano | |||||
| 1938 | 1942 | José de Yanguas Messía | [23] | ||||
| 1942 | 1945 | Domingo de las Bárcenas y Lopez-Mollinedo Mercado | [24] | ||||
| 1946 | 1948 | Pablo de Churruca y Dotres, Marquess of Aycinena | previously Ambassador in Lima[25] | ||||
| 1948 | 1951 | Joaquín Ruiz-Giménez Cortés | |||||
| 1951 | 1956 | Fernando María Castiella y Maíz | |||||
| 1957 | 1962 | Francisco Gómez de Llano | |||||
| 1962 | 1964 | José María Doussinague y Texidor | |||||
| 1964 | 1972 | Antonio Garrigues Díaz-Cañabate, Marquess of Garrigues. | |||||
| 1972 | 1973 | Juan Pablo de Lojendio e Irure | [26] | ||||
| 1973 | 1974 | Gabriel Martínez de Mata | |||||
| 1974 | 1976 | Gabriel Fernández de Valderrama y Moreno | |||||
| 1976 | 1977 | Gonzalo Fernández de Córdova y Moreno | |||||
| 1977 | 1980 | Ángel Sanz-Briz | |||||
| 1980 | 1983 | José Joaquín Puig de la Bellacasa y Urdampilleta | |||||
| 1983 | 1985 | Nuño Aguirre de Cárcer y López de Sagredo | [27] | ||||
| 1985 | 1987 | Gonzalo Puente Ojea | |||||
| 1987 | 1992 | Jesús Ezquerra Calvo | |||||
| 1992 | 1997 | Pedro López de Aguirrebengoa | |||||
| 1997 | 2004 | Carlos Abella y Ramallo | [28] | ||||
| 2004 | 2006 | Jorge Dezcallar de Mazarredo | |||||
| 2006 | 2011 | Francisco Vázquez Vázquez | |||||
| 2011 | 2012 | María Jesús Figa López-Palop | |||||
| 2012 | 2017 | Eduardo Gutiérrez Sáenz de Buruaga | |||||
| 2017 | 2018 | Gerardo Ángel Bugallo Ottone | |||||
| 2018 | 2021 | María del Carmen de la Peña Corcuera | |||||
| 2022 | Incumbent | María Isabel Celaá Diéguez |