This is a list of airlines currently operating in São Tomé and Príncipe.
| Airline | Image | IATA | ICAO | Callsign | Commenced operations | Notes | |
|---|---|---|---|---|---|---|---|
| Africa's Connection STP | ACH | 2011 | |||||
| Goliaf Air | GLE | 1997 | |||||
| SAL Express | 1999 | ||||||
| STP Airways | 8F | STP | SAOTOME AIRWAYS | 2008 | |||
| Transafrik International | TFK | 1984 | |||||
| Transliz Aviation | TLZ | 2007 | |||||
| TRAST Aero Atlantic | TRE | 2008 |