List of adverse effects of axitinib explained

This is a list of adverse effects of the anti-cancer drug axitinib, sorted by frequency of occurrence.^{[1] [2] [3] [4] [5] [6]}

Very common

Very common (>10% incidence) adverse effects include:

• Underactive thyroid
• Decreased appetite
• Headache
• Dizziness
• Taste changes
• Haemorrhage
• High blood pressure
• Cough
• Shortness of breath
• Speech disorder
• Diarrhoea
• Nausea
• Vomiting
• Abdominal pain
• Stomatitis
• Indigestion
• Hand-foot syndrome
• Dry skin
• Rash
• Joint aches and pains
• Pain in the extremities
• Proteinuria
• Fatigue
• Asthenia
• Mucosal inflammation
• Weight loss

Common

Common (1–10% incidence) adverse effects include:

• Anaemia
• Thrombocytopenia
• Hyperthyroidism
• TSH-increased
• Dehydration
• High blood potassium
• High blood calcium
• Ringing in the ears
• Venous embolic and thrombotic events
• Arterial embolic and thrombotic events
• Oropharyngeal pain
• Flatulence
• Haemorrhoids
• Glossodynia
• Hyperbilirubinaemia
• Itchiness
• Erythema
• Hair loss
• Myalgia
• Kidney failure
• Increased lipase
• Increases alanine aminotransferase
• Increased amylase
• Increased aspartate aminotransferase
• Increased alkaline phosphatase
• Increased creatinine

Uncommon

Uncommon (0.1–1% incidence) adverse effects include:

• Gastrointestinal Perforation and fistula
• Reversible posterior leukoencephalopathy syndrome
• Polycythaemia

Notes and References

1. Web site: Inlyta (axitinib) dosing, indications, interactions, adverse effects, and more. Medscape Reference. WebMD. 25 January 2014.
2. Web site: INLYTA (axitinib) tablet, film coated [Pfizer Laboratories Div Pfizer Inc]]. DailyMed. Pfizer Laboratories Div Pfizer Inc. September 2013. 25 January 2014.
3. Web site: Inlyta : EPAR - Product Information. European Medicines Agency. Pfizer Ltd.. 17 December 2013. 25 January 2014.
4. Web site: Inlyta 1 mg 3mg, 5 mg & 7mg film-coated tablets - Summary of Product Characteristics (SPC). electronic Medicines Compendium. Pfizer Limited. 5 December 2013. 25 January 2014. https://web.archive.org/web/20140222203314/http://www.medicines.org.uk/emc/medicine/27051/SPC/Inlyta+1+mg+3mg%2C+5+mg+%26+7mg+film-coated+tablets/. 22 February 2014. dead.
5. Web site: PRODUCT INFORMATION INLYTA (axitinib). TGA eBusiness Services. Pfizer Australia Pty Ltd. 5 July 2013. 25 January 2014. PDF.
6. Book: Rossi, S . 978-0-9805790-9-3 . Australian Medicines Handbook . Adelaide . The Australian Medicines Handbook Unit Trust . 2013 . 2013 .