List of adverse effects of aripiprazole explained

The rates of adverse effects of aripiprazole are:^{[1] [2] [3] [4] [5]}

Adults

Very common (>10% incidence)

• Weight gain
• Headache
• Agitation
• Insomnia
• Anxiety
• Nausea & vomiting
• Akathisia — a sense of unease and restlessness that presents itself with anxiety
• Lightheadedness
• Constipation
• Emotional instability
• Euphoria or Dysphoria

Common (1–10% incidence)

• Dizziness
• Dyspepsia — indigestion
• Somnolence — which is usually mild and transient and less severe than that seen with most antipsychotics.^[6]
• Fatigue
• Restlessness
• Dry mouth
• Extrapyramidal side effects (e.g. dystonia, parkinsonism, tremor, myoclonic jerks, etc.)
• Orthostatic hypotension
• Musculoskeletal stiffness
• Abdominal discomfort
• Blurred vision
• Cough
• Pain
• Myalgia
  • Rash Rhinitis

Uncommon (0.1–1% incidence)

• Leukopenia
• Thrombocytopenia
• Bradycardia (low heart rate)
• Palpitations
• Orthostatic hypotension
• Dry eye
• Photophobia
• Diplopia
• Eyelid oedema
• Photopsia
• Diarrhoea
• Gastritis
• Pathological gambling
• Dysphagia
• Gastroesophageal reflux disease
• Swollen tongue
• Oesophagitis
• Hypoaesthesia oral
• Face oedema
• Gait disturbance
• Chills
• Discomfort
• Feeling abnormal
• Mobility decreased
• Self-mutilation
• Heart rate increased
• Blood glucose increased
• Pyrexia
• Blood prolactin increased
• Blood urea increased
• Electrocardiogram QT prolonged
• Blood bilirubin increased
• Hepatic enzyme increased
• Increased appetite
• Nocturia
• Polyuria
• Pollakiuria
• Incontinence
• Urinary retention
• Sexual dysfunction
• Amenorrhoea
• Pruritus
• Photosensitivity reaction
• Urticaria

Rare (<0.1%)

• Neuroleptic malignant syndrome (Combination of fever, muscle stiffness, faster breathing, sweating, reduced consciousness, and sudden change in blood pressure and heart rate)
• Neutropenia^[7]
• Suicidal ideation and behavior
• Depression
• Painful and/or sustained erection (Priapism)
• Seizures^[8]
• Rhabdomyolysis
• Agranulocytosis
• Cardiopulmonary failure
• Myocardial infarction (heart attack)
• Atrial flutter
• Supraventricular tachycardia
• Ventricular tachycardia
• Atrioventricular block
• Extrasystoles
• Sinus tachycardia
• Atrial fibrillation
• Angina pectoris
• Myocardial ischaemia
• Pancreatitis
• Diabetic ketoacidosis
• Prolonged QT interval (less common than with most other atypical antipsychotic drugs)^[6]
• Speech disorder
• Electrolyte abnormalities including hyponatraemia, hypokalaemia, hypocalcaemia, etc.
• Hypertension
• Dysphagia
• Oropharyngeal spasm
• Laryngospasm
• Hepatitis
• Jaundice
• Hypersalivation
• Chest pain
• Urinary retention or incontinence
• Alopecia (hair loss)
• Photosensitivity reaction
• Rash
• Xerostomia (when given by injection)
• Tardive dyskinesia (As with all antipsychotic medication, patients using aripiprazole may develop the permanent neurological disorder tardive dyskinesia.)^{[9] [10] [11]}
• Stroke
• Transient Ischaemic Attack
• Increased body temperature
• Angioedema
• Cardiorespiratory arrest
• Cardiorespiratory failure

Sudden unexplained death has been reported, however the frequency is unknown.^[12]

Common in children

• Feeling sleepy
• Headache
• Vomiting
• Fatigue
• Increased appetite
• Insomnia
• Nausea
• Stuffy nose
• Weight gain
• Uncontrolled movement such as restlessness, tremor muscle stiffness^[13]

Notes and References

1. Web site: Product Information for ABILIFY Aripiprazole Tablets & Orally Disintegrating Tablets. TGA eBusiness Services. Bristol-Myers Squibb Australia Pty Ltd. 1 November 2012. 22 October 2013.
2. Web site: ABILIFY (aripiprazole) tablet ABILIFY (aripiprazole) solution ABILIFY DISCMELT (aripiprazole) tablet, orally disintegrating ABILIFY (aripiprazole) injection, solution [Otsuka America Pharmaceutical, Inc.]]. April 2013. 22 October 2013. Otsuka America Pharmaceutical, Inc.. DailyMed.
3. Web site: Abilify Tablets, Orodispersible Tablets, Oral Solution - Summary of Product Characteristics (SPC). 20 September 2013. 22 October 2013. Otsuka Pharmaceuticals (UK) Ltd. electronic Medicines Compendium. https://web.archive.org/web/20160304001126/http://www.medicines.org.uk/emc/medicine/18494/SPC/Abilify+Tablets,+Orodispersible+Tablets,+Oral+Solution/. 4 March 2016. dead.
4. Web site: ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS. European Medicines Agency. Otsuka Pharmaceutical Europe Ltd.. 22 October 2013.
5. Web site: Abilify Discmelt, Abilify Maintena (aripiprazole) dosing, indications, interactions, adverse effects, and more. 22 October 2013. Medscape Reference. WebMD.
6. Leucht S, Cipriani A, Spineli L, Mavridis D, Orey D, Richter F, Samara M, Barbui C, Engel RR, Geddes JR, Kissling W, Stapf MP, Lässig B, Salanti G, Davis JM . Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. . Lancet . 382 . 9896 . 951–962 . September 2013 . 23810019 . 10.1016/S0140-6736(13)60733-3 . 32085212 .
7. Felin . Tricia . Naveed . Sadiq . Chaudhary . Amna M. . Aripiprazole-Induced Neutropenia: Case Report and Literature Review . Journal of Psychosocial Nursing and Mental Health Services . SLACK, Inc. . 56 . 5 . 2018-05-01 . 0279-3695 . 29715374 . 10.3928/02793695-20180419-02 . 21–24.
8. Thabet . Farouq I. . Sweis . Rochelle T. . Joseph . Suja A. . Aripiprazole-Induced Seizure in a 3-Year-Old Child . Clinical Neuropharmacology . Ovid Technologies (Wolters Kluwer Health) . 36 . 1 . 2013 . 0362-5664 . 10.1097/wnf.0b013e3182767efb . 29–30. 23334073 .
9. Abbasian C, Power P . A case of aripiprazole and tardive dyskinesia . J Psychopharmacol (Oxford) . 23 . 2 . 214–5 . March 2009 . 18515468 . 10.1177/0269881108089591 . 206489666 .
10. Zaidi SH, Faruqui RA . Aripiprazole is associated with early onset of Tardive Dyskinesia like presentation in a patient with ABI and psychosis . Brain Inj . 22 . 1 . 99–102 . January 2008 . 18183513 . 10.1080/02699050701822493 . 11197371 .
11. Maytal G, Ostacher M, Stern TA . Aripiprazole-related tardive dyskinesia . CNS Spectr . 11 . 6 . 435–9 . June 2006 . 10.1017/s1092852900014632 . 16816781 . 41849016 .
12. http://www.medicines.org.uk/EMC/pdfviewer.aspx?isAttachment=true&documentid=16161
13. Web site: ABILIFY (aripiprazole) [package insert]. ]. 18 October 2012 . Otsuka Pharmaceutical Co, Ltd.