The following is a list of actors who have played Professor Moriarty in various media.
| Name | Title | Date | Type |
|---|---|---|---|
| Louis Hector | The Adventures of Sherlock Holmes – "The Missing Leonardo Da Vinci"[1] | 1932 | Radio (NBC Blue Network) |
| Charles Bryant | Lux Radio Theatre – "Sherlock Holmes"[2] | 1935 | Radio adaptation of the play (NBC) |
| Eustace Wyatt | The Mercury Theatre on the Air – "Sherlock Holmes" | 1938 | Radio adaptation of the play (CBS) |
| Joseph Kearns | The New Adventures of Sherlock Holmes – "The Singular Case of the Paradol Chamber"[3] | 1945 | Radio (Mutual) |
| Denis Green | The New Adventures of Sherlock Holmes – "The April Fool's Adventure"[4] | 1946 | |
| Robert Dryden | The New Adventures of Sherlock Holmes – "The Guest in the Coffin"[5] | 1949 | |
| Frederick Valk | Sherlock Holmes[6] | 1953 | Radio adaptation of the play (BBC) |
| Orson Welles | The Adventures of Sherlock Holmes – "The Final Problem"[7] | 1954 | BBC Light Programme |
| Ralph Truman | Sherlock Holmes – "The Final Problem"[8] | 1955 | BBC Home Service |
| Felix Felton | Sherlock Holmes – "The Final Problem"[9] | 1957 | BBC Home Service |
| Rolf Lefebvre | Sherlock Holmes – "The Final Problem"[10] | 1967 | BBC Light Programme |
| Michael Pennington | BBC Radio Sherlock Holmes – "The Final Problem", "The Empty House" | 1992 | BBC Radio 4 |
| Ronald Pickup | BBC Radio Sherlock Holmes – The Valley of Fear[11] | 1997 | BBC Radio 4 |
| David King | The Seven-Per-Cent Solution | 1993 | BBC radio dramatisation of the novel |
| Geoffrey Whitehead | The Newly Discovered Casebook of Sherlock Holmes | 1999 | BBC Radio 2 |
| Nolan Palmer | The Further Adventures of Sherlock Holmes – "The Moriarty Resurrection"[12] | 2006 | Radio (Imagination Theatre) |
| Richard Ziman | The Classic Adventures of Sherlock Holmes – "The Return of Sherlock Holmes"[13] | 2009 | |
| Alan Cox | Sherlock Holmes: The Final Problem/The Empty House[14] | 2011 | Audio drama (Big Finish Productions) |
| Gerard McDermott | Sherlock Holmes: The Voice of Treason[15] | 2020 | Audio drama (Audible Original) |
| Dominic Monaghan | Moriarty: The Devil's Game[16] | 2022 | Audio drama (Audible Original) |
| Name | Title | Date | Type |
|---|---|---|---|
| George Wessells | Sherlock Holmes | 1899 | Broadway (American) |
| Frank Keenan | Sherlock Holmes | 1928 | Broadway (American) |
| Thomas Gomez | "Sherlock Holmes" by Ouida Bergère[17] | 1953 | Broadway (American) |
| Martin Gabel | Baker Street | 1965 | Stage musical (Broadway) |
| Terry Williams | 1988 | Stage musical (Exeter, England) | |
| Name | Title | Date | Type |
|---|---|---|---|
| John Huston | Sherlock Holmes in New York | 1976 | Television film (American) |
| Viktor Yevgrafov | The Adventures of Sherlock Holmes and Dr. Watson | 1980 | Television film (USSR) |
| Anthony Andrews | Hands of a Murderer | 1990 | Television film (British) |
| Vincent D'Onofrio | 2002 | Television film (American) | |
| Steve Powell | 2010 | Japanese anime film (English dub, released on DVD) | |
| Malcolm McDowell | Tom and Jerry Meet Sherlock Holmes | 2010 | Animated direct-to-DVD film (American) |
| Name | Title | Date | Type | |
|---|---|---|---|---|
| Colin Jeavons | The Baker Street Boys – "The Adventure of the Winged Scarab" Parts 1 and 2 | 1983 | TV episodes (British) | |
| Chikao Ōtsuka | Sherlock Hound | 1984–1985 | TV animated series (Italian-Japanese) (Japanese version) | |
| Hamilton Camp | Sherlock Hound | 1984–1985 | TV animated series (Italian-Japanese) (English dub) | |
| Mauro Bosco | Sherlock Hound | 1984–1985 | TV animated series (Italian-Japanese) (Italian dub) | |
| Eric Porter | Sherlock Holmes | 1985 | TV series (British) | |
| Daniel Davis | – "Elementary, Dear Data" and "Ship in a Bottle" Star Trek Picard (Season 3) | 1988, 1993, 2023 | TV episodes (American) | |
| John Colicos | Alfred Hitchcock Presents – "My Dear Watson" | 1989 | TV episode (American) | |
| Richard Newman | Sherlock Holmes in the 22nd Century | 1999–2001 | TV series (British-American) | |
| Andrew Scott | Sherlock | 2010–2017 | TV series (British) | |
| Natalie Dormer | Elementary | 2013–2015 | TV series (American) | |
| Alexey Gorbunov | Sherlock Holmes | 2013 | TV series (Russian) | |
| Masashi Ebara | Sherlock Holmes | 2014–2015 | TV series (Japanese) | |
| David S. Lee | The Librarians | 2015 | TV series (American) | |
| Shima Ōnishi | 2019 | TV series (Japanese) | ||
| Seiichirō Yamashita | 2019–2020 | TV anime series (Japanese) (Japanese version) | ||
| Justin Briner | 2019–2020 | TV anime series (Japanese) (English dub) | ||
| Sōma Saitō | Moriarty the Patriot | 2020–2021 | TV anime series (Japanese) | |
| Aaron Dismuke | Moriarty the Patriot | 2020–2021 | TV anime series (Japanese) (English dub) | |
| Shizuka Ishigami | Moriarty the Patriot | 2020–2021 | TV anime series (Japanese) (Younger version) | |
| Emily Neves | Moriarty the Patriot | 2020–2021 | TV anime series (Japanese) (Younger version) (English dub) | |
| Dougray Scott | Sherlock & Daughter | 2025 | TV series (American-British) | |
| Dónal Finn | Young Sherlock | 2025 | TV series (British) |
| Name | Title | Date | Type |
|---|---|---|---|
| Roger L. Jackson | [18] [19] | 1996 | Voice only; digitized sprites based on a different actor |
| George Gregg | 1996 | Digitized-sprite actor | |
| Unknown actor | The Testament of Sherlock Holmes | 2012 | Sherlock Holmes series; voice role |
| Unknown actor | 2016 | ||
| Takaya Hashi | Fate/Grand Order (Limited event character)[20] [21] | 2017 | Mobile game; voice role (Japanese) |