This is a list of Western Oregon Wolves players in the NFL Draft.
| B | Back | K | Kicker | NT | Nose tackle |
| C | Center | LB | Linebacker | FB | Fullback |
| DB | Defensive back | P | Punter | HB | Halfback |
| DE | Defensive end | QB | Quarterback | WR | Wide receiver |
| DT | Defensive tackle | RB | Running back | G | Guard |
| E | End | T | Offensive tackle | TE | Tight end |
| = Pro Bowler | ||
| = Hall of Famer |
| Year | Round | Pick | Overall | Player | Team | Position |
|---|---|---|---|---|---|---|
| 2001 | 7 | 25 | 225 | Brian Crawford | Minnesota Vikings | OT |
| 2007 | 5 | 16 | 153 | Kevin Boss | New York Giants | TE |
| 2012 | 6 | 29 | 199 | Jason Slowey | San Francisco 49ers | C |