Mississippi was admitted to the Union on December 10, 1817, and elects senators to class 1 and class 2. Its current senators are Republicans Cindy Hyde-Smith and Roger Wicker. As of February 2022, 51 people have served as U.S. senators from Mississippi. John C. Stennis was Mississippi's longest-serving senator (1947–1989).
Mississippi last elected a Democrat in 1982, and both seats have been occupied by the Republicans since 1989.
|- style="height:2em"! rowspan=2 | 1| rowspan=2 align=left |
Walter Leake| rowspan=2 | Democratic-
Republican| rowspan=2 nowrap | Dec 10, 1817 –
May 15, 1820| rowspan=2 | Elected in 1817.Resigned.| rowspan=4 | 1| | rowspan=5 | 1| rowspan=5 | Elected in 1817.| rowspan=11 nowrap | Dec 10, 1817 –
Mar 4, 1829| rowspan=6 | Democratic-
Republican| rowspan=11 align=right |
Thomas Hill Williams! rowspan=11 | 1
|- style="height:2em"|
|- style="height:2em"| colspan=3 | Vacant| nowrap | May 15, 1820 –
Aug 30, 1820|
|- style="height:2em"! rowspan=4 | 2| rowspan=4 align=left |
David Holmes| rowspan=3 | Democratic-
Republican| rowspan=4 nowrap | Aug 30, 1820 –
Sep 25, 1825| Elected to finish Leake's term.
|- style="height:2em"| rowspan=3 | Re-election year unknown.Resigned to become Governor of Mississippi.| rowspan=6 | 2|
|- style="height:2em"| | rowspan=6 | 2| rowspan=6 | Re-elected in 1823.
|- style="height:2em"| | Jacksonian| | rowspan=5 | Jacksonian
|- style="height:2em"| colspan=3 | Vacant| nowrap | Sep 25, 1825 –
Sep 28, 1825|
|- style="height:2em"! 3| align=left |
Powhatan Ellis| | Jacksonian| nowrap | Sep 28, 1825 –
Jan 28, 1826| Appointed to continue Holmes's term.Lost election to finish Holmes's term.
|- style="height:2em"! 4| align=left |
Thomas Buck Reed| | Jacksonian| nowrap | Jan 28, 1826 –
Mar 4, 1827| Elected to finish Holmes's term.Lost election to full term.
|- style="height:2em"! rowspan=7 | 5| rowspan=7 align=left |
Powhatan Ellis| rowspan=7 | Jacksonian| rowspan=7 nowrap | Mar 4, 1827 –
Jul 16, 1832| rowspan=7 | Election year unknown.Resigned to become a U.S. District Judge.| rowspan=9 | 3|
|- style="height:2em"| | rowspan=10 | 3| Elected in 1828.Died.| nowrap | Mar 4, 1829 –
Nov 26, 1829| | Jacksonian| align=right |
Thomas Buck Reed! 2
|- style="height:2em"| | nowrap | Nov 26, 1829 –
Jan 6, 1830| colspan=3 | Vacant
|- style="height:2em"| Elected to finish Reed's term.Died.| nowrap | Jan 6, 1830 –
Jul 2, 1830| | Jacksonian| align=right | Robert H. Adams! 3
|- style="height:2em"| | nowrap | Jul 2, 1830 –
Oct 15, 1830| colspan=3 | Vacant
|- style="height:2em"| rowspan=6 | Appointed to continue Adams's term.Elected in 1830 to finish Adams's term.Lost re-election.| rowspan=6 nowrap | Oct 15, 1830 –
Mar 4, 1835| | Jacksonian| rowspan=6 align=right |
George Poindexter! rowspan=6 | 4
|- style="height:2em"| | rowspan=5 | National
Republican
|- style="height:2em"| colspan=3 | Vacant| nowrap | Jul 16, 1832 –
Nov 12, 1832|
|- style="height:2em"! rowspan=5 | 6| align=left |
John Black| | Jacksonian| nowrap | Nov 12, 1832 –
Mar 4, 1833| Appointed to finish Ellis's term.
|- style="height:2em"| colspan=2 | Vacant| nowrap | Mar 4, 1833 –
Nov 22, 1833| Legislature failed to elect.| rowspan=7 | 4|
|- style="height:2em"| rowspan=3 align=left |
John Black| rowspan=2 | National
Republican| rowspan=3 nowrap | Nov 22, 1833 –
Jan 22, 1838| rowspan=3 | Elected late.Resigned.
|- style="height:2em"| | rowspan=6 | 4| rowspan=6 | Elected in 1835.| rowspan=9 nowrap | Mar 4, 1835 –
Mar 5, 1845| | Jacksonian| rowspan=9 align=right |
Robert J. Walker! rowspan=9 | 5
|- style="height:2em"| | Whig| | rowspan=8 | Democratic
|- style="height:2em"! 7| align=left |
James F. Trotter| | Democratic| nowrap | Jan 22, 1838 –
Jul 10, 1838| Appointed to continue Black's term.Resigned.
|- style="height:2em"| colspan=3 | Vacant| nowrap | Jul 10, 1838 –
Nov 12, 1838|
|- style="height:2em"! 8| align=left | Thomas H. Williams| | Democratic| nowrap | Nov 12, 1838 –
Mar 4, 1839| Appointed to continue Black's term.Elected in 1839 to finish Black's term..
|- style="height:2em"! rowspan=3 | 9| rowspan=3 align=left |
John Henderson| rowspan=3 | Whig| rowspan=3 nowrap | Mar 4, 1839 –
Mar 4, 1845| rowspan=3 | Elected in 1838..| rowspan=3 | 5|
|- style="height:2em"| | rowspan=5 | 5| rowspan=3 | Re-elected in 1841.Resigned to become U.S. Secretary of the Treasury.
|- style="height:2em"|
|- style="height:2em"! rowspan=4 | 10| rowspan=4 align=left |
Jesse Speight| rowspan=4 | Democratic| rowspan=4 nowrap | Mar 4, 1845 –
May 1, 1847| rowspan=4 | Elected in 1844.Died.| rowspan=7 | 6|
|- style="height:2em"| | nowrap | Mar 5, 1845 –
Nov 3, 1845| colspan=3 | Vacant
|- style="height:2em"| Appointed to continue Walker's term.Elected in 1846 to finish Walker's term..| nowrap | Nov 3, 1845 –
Mar 4, 1847| | Democratic| align=right | Joseph W. Chalmers! 6
|- style="height:2em"| | rowspan=10 | 6| rowspan=7 | Elected in 1846 or 1847.Resigned to become Governor of Mississippi.| rowspan=7 nowrap | Mar 4, 1847 –
Jan 8, 1852| rowspan=7 | Democratic| rowspan=7 align=right |
Henry S. Foote! rowspan=7 | 7
|- style="height:2em"| colspan=3 | Vacant| nowrap | May 1, 1847 –
Aug 10, 1847|
|- style="height:2em"! rowspan=3 | 11| rowspan=3 align=left |
Jefferson Davis| rowspan=3 | Democratic| rowspan=3 nowrap | Aug 10, 1847 –
Sep 23, 1851| rowspan=2 | Appointed to continue Speight's term.Elected in 1848 to finish Speight's term.
|- style="height:2em"|
|- style="height:2em"| Re-elected in 1850.Resigned to run for Governor of Mississippi.| rowspan=9 | 7|
|- style="height:2em"| colspan=3 | Vacant| nowrap | Sep 23, 1851 –
Dec 1, 1851|
|- style="height:2em"! rowspan=3 | 12| rowspan=3 align=left |
John J. McRae| rowspan=3 | Democratic| rowspan=3 nowrap | Dec 1, 1851 –
Mar 17, 1852| rowspan=3 | Appointed to continue Davis's term.Successor elected.
|- style="height:2em"| | nowrap | Jan 8, 1852 –
Feb 18, 1852| colspan=3 | Vacant
|- style="height:2em"| rowspan=2 | Elected to finish Foote's term.Retired.| rowspan=2 nowrap | Feb 18, 1852 –
Mar 4, 1853| rowspan=2 | Whig| rowspan=2 align=right |
Walker Brooke! rowspan=2 | 8
|- style="height:2em"! rowspan=4 | 13| rowspan=4 align=left |
Stephen Adams| rowspan=4 | Democratic| rowspan=4 nowrap | Mar 17, 1852 –
Mar 4, 1857| rowspan=4 | Elected to finish Davis's term..
|- style="height:2em"| | rowspan=4 | 7| | nowrap | Mar 4, 1853 –
Jan 7, 1854| colspan=3 | Vacant
|- style="height:2em"| rowspan=3 | Elected late in 1854| rowspan=4 nowrap | Jan 7, 1854 –
Jan 12, 1861| rowspan=4 | Democratic| rowspan=4 align=right |
Albert G. Brown! rowspan=4 | 9
|- style="height:2em"|
|- style="height:2em"! rowspan=3 | 14| rowspan=3 align=left |
Jefferson Davis| rowspan=3 | Democratic| rowspan=3 nowrap | Mar 4, 1857 –
Jan 21, 1861| rowspan=3 | Elected in 1856 or 1857.Resigned.| rowspan=5 | 8|
|- style="height:2em"| | rowspan=5 | 8| Re-elected in 1859.Withdrew.
|- style="height:2em"| rowspan=7 | Civil War and Reconstruction| rowspan=7 nowrap | Jan 12, 1861 –
Feb 23, 1870| rowspan=7 colspan=3 | Vacant
|- style="height:2em"| rowspan=6 colspan=3 | Vacant| rowspan=6 nowrap | Jan 21, 1861 –
Feb 23, 1870| rowspan=6 | Civil War and Reconstruction
|- style="height:2em"|
|- style="height:2em"| rowspan=3 | 9|
|- style="height:2em"| | rowspan=4 | 9
|- style="height:2em"|
|- style="height:2em"| rowspan=6 | 10|
|- style="height:2em"! rowspan=4 | 15| rowspan=4 align=left |
Adelbert Ames| rowspan=4 | Republican| rowspan=4 nowrap | Feb 23, 1870 –
Jan 4, 1874| rowspan=4 | Elected in 1870 upon readmission.Resigned to become Governor of Mississippi.| Elected in 1870 upon readmission..| nowrap | Feb 23, 1870 –
Mar 4, 1871| | Republican| align=right |
Hiram R. Revels! 10
|- style="height:2em"| | rowspan=6 | 10| | nowrap | Mar 4, 1871 –
Dec 1, 1871| colspan=3 | Vacant
|- style="height:2em"| rowspan=5 | Elected in 1870, but remained Governor until Dec 1871..| rowspan=5 nowrap | Dec 1, 1871 –
Mar 4, 1877| rowspan=5 | Republican| rowspan=5 align=right |
James L. Alcorn! rowspan=5 | 11
|- style="height:2em"|
|- style="height:2em"| colspan=3 | Vacant| nowrap | Jan 4, 1874 –
Feb 3, 1874|
|- style="height:2em"! 16| align=left |
Henry R. Pease| | Republican| nowrap | Feb 3, 1874 –
Mar 4, 1875| Elected to finish Ames's term.Retired.|
|- style="height:2em"! rowspan=3 | 17| rowspan=3 align=left |
Blanche Bruce| rowspan=3 | Republican| rowspan=3 nowrap | Mar 4, 1875 –
Mar 4, 1881| rowspan=3 | Elected in 1874..| rowspan=3 | 11|
|- style="height:2em"| | rowspan=3 | 11| rowspan=3 | Elected in 1876.| rowspan=5 nowrap | Mar 4, 1877 –
Mar 6, 1885| rowspan=5 | Democratic| rowspan=5 align=right |
Lucius Q. C. Lamar! rowspan=5 | 12
|- style="height:2em"|
|- style="height:2em"! rowspan=13 | 18| rowspan=13 align=left |
James Z. George| rowspan=13 | Democratic| rowspan=13 nowrap | Mar 4, 1881 –
Aug 14, 1897| rowspan=5 | Elected in 1880.| rowspan=5 | 12|
|- style="height:2em"| | rowspan=5 | 12| rowspan=2 | Re-elected in 1883.Resigned.
|- style="height:2em"|
|- style="height:2em"| | nowrap | Mar 6, 1885 –
Mar 9, 1885| colspan=3 | Vacant
|- style="height:2em"| rowspan=2 | Appointed to continue Lamar's term.Elected in 1886 to finish Lamar's term.| rowspan=5 nowrap | Mar 9, 1885 –
Jan 24, 1894| rowspan=5 | Democratic| rowspan=5 align=right |
Edward C. Walthall! rowspan=5 | 13
|- style="height:2em"| rowspan=3 | Re-elected in 1886.| rowspan=3 | 13|
|- style="height:2em"| | rowspan=5 | 13| rowspan=3 | Re-elected in 1889.Resigned.
|- style="height:2em"|
|- style="height:2em"| rowspan=5 | Re-elected in 1892.[1] Died.| rowspan=9 | 14|
|- style="height:2em"| | nowrap | Jan 24, 1894 –
Feb 7, 1894| colspan=3 | Vacant
|- style="height:2em"| Elected to finish Walthall's term..| nowrap | Feb 7, 1894 –
Mar 4, 1895| | Democratic| align=right |
Anselm J. McLaurin! 14
|- style="height:2em"| | rowspan=7 | 14| rowspan=4 | Elected early in 1892.[1] Died.| rowspan=4 nowrap | Mar 4, 1895 –
Apr 21, 1898| rowspan=4 | Democratic| rowspan=4 align=right |
Edward C. Walthall! rowspan=4 | 15
|- style="height:2em"|
|- style="height:2em"| colspan=3 | Vacant| nowrap | Aug 14, 1897 –
Oct 8, 1897|
|- style="height:2em"! rowspan=12 | 19| rowspan=12 align=left |
Hernando Money| rowspan=12 | Democratic| rowspan=12 nowrap | Oct 8, 1897 –
Mar 4, 1911| rowspan=3 | Appointed to finish George's term.
|- style="height:2em"| | nowrap | Apr 21, 1898 –
May 31, 1898| colspan=3 | Vacant
|- style="height:2em"| rowspan=2 | Appointed to continue Walthall's term.Elected in 1900 to finish Walthall's term.Retired.| rowspan=2 nowrap | May 31, 1898 –
Mar 4, 1901| rowspan=2 | Democratic| rowspan=2 align=right |
William V. Sullivan! rowspan=2 | 16
|- style="height:2em"| rowspan=3 | Elected to full term in 1899.| rowspan=3 | 15|
|- style="height:2em"| | rowspan=3 | 15| rowspan=3 | Elected in 1900.| rowspan=5 nowrap | Mar 4, 1901 –
Dec 22, 1909| rowspan=5 | Democratic| rowspan=5 align=right |
Anselm J. McLaurin! rowspan=5 | 17
|- style="height:2em"|
|- style="height:2em"| rowspan=6 | Re-elected in 1904.[2] Retired.| rowspan=6 | 16|
|- style="height:2em"| | rowspan=6 | 16| rowspan=2 | Re-elected early in 1904.[2] Died.
|- style="height:2em"|
|- style="height:2em"| | nowrap | Dec 22, 1909 –
Dec 27, 1909| colspan=3 | Vacant
|- style="height:2em"| Appointed to continue McLaurin's term.Successor qualified.| nowrap | Dec 27, 1909 –
Feb 22, 1910| | Democratic| align=right |
James Gordon! 18
|- style="height:2em"| rowspan=2 | Elected to finish McLaurin's term.Lost nomination to full term.| rowspan=2 nowrap | Feb 23, 1910 –
Mar 4, 1913| rowspan=2 | Democratic| rowspan=2 align=right |
LeRoy Percy! rowspan=2 | 19
|- style="height:2em"! rowspan=6 | 20| rowspan=6 align=left |
John Sharp Williams| rowspan=6 | Democratic| rowspan=6 nowrap | Mar 4, 1911 –
Mar 4, 1923| rowspan=3 | Elected early in 1908.| rowspan=3 | 17|
|- style="height:2em"| | rowspan=3 | 17| rowspan=3 | Elected in 1912.Lost renomination.| rowspan=3 nowrap | Mar 4, 1913 –
Mar 4, 1919| rowspan=3 | Democratic| rowspan=3 align=right |
James K. Vardaman! rowspan=3 | 20
|- style="height:2em"|
|- style="height:2em"| rowspan=3 | Re-elected in 1916.Retired.| rowspan=3 | 18|
|- style="height:2em"| | rowspan=3 | 18| rowspan=3 | Elected in 1918.| rowspan=12 nowrap | Mar 4, 1919 –
Jun 22, 1941| rowspan=12 | Democratic| rowspan=12 align=right |
Pat Harrison! rowspan=12 | 21
|- style="height:2em"|
|- style="height:2em"! rowspan=6 | 21| rowspan=6 align=left |
Hubert D. Stephens| rowspan=6 | Democratic| rowspan=6 nowrap | Mar 4, 1923 –
Jan 3, 1935| rowspan=3 | Elected in 1922.| rowspan=3 | 19|
|- style="height:2em"| | rowspan=3 | 19| rowspan=3 | Re-elected in 1924.
|- style="height:2em"|
|- style="height:2em"| rowspan=3 | Re-elected in 1928.Lost renomination.| rowspan=3 | 20|
|- style="height:2em"| | rowspan=3 | 20| rowspan=3 | Re-elected in 1930.
|- style="height:2em"|
|- style="height:2em"! rowspan=10 | 22| rowspan=10 align=left |
Theodore G. Bilbo| rowspan=10 | Democratic| rowspan=10 nowrap | Jan 3, 1935 –
Aug 21, 1947| rowspan=3 | Elected in 1934.| rowspan=3 | 21|
|- style="height:2em"| | rowspan=6 | 21| rowspan=3 | Re-elected in 1936.Died.
|- style="height:2em"|
|- style="height:2em"| rowspan=6 | Re-elected in 1940.| rowspan=6 | 22|
|- style="height:2em"| | nowrap | Jun 22, 1941 –
Jun 30, 1941| colspan=3 | Vacant
|- style="height:2em"| Appointed to continue Harrison's term.Retired when successor elected.| nowrap | Jun 30, 1941 –
Sep 28, 1941| | Democratic| align=right |
James Eastland! 22
|- style="height:2em"| Elected to finish Harrison's term.Lost renomination.| nowrap | Sep 29, 1941 –
Jan 3, 1943| | Democratic| align=right |
Wall Doxey! 23
|- style="height:2em"| | rowspan=5 | 22| rowspan=5 | Elected in 1942.| rowspan=20 nowrap | Jan 3, 1943 –
Dec 27, 1978| rowspan=20 | Democratic| rowspan=20 align=right |
James Eastland! rowspan=20 | 24
|- style="height:2em"|
|- style="height:2em"| Re-elected in 1946.Died.| rowspan=5 | 23|
|- style="height:2em"| colspan=3 | Vacant| nowrap | Aug 21, 1947 –
Nov 5, 1947|
|- style="height:2em"! rowspan=22 | 23| rowspan=22 align=left |
John C. Stennis| rowspan=22 | Democratic| rowspan=22 nowrap | Nov 5, 1947 –
Jan 3, 1989| rowspan=3 | Elected to finish Bilbo's term.
|- style="height:2em"| | rowspan=3 | 23| rowspan=3 | Re-elected in 1948.
|- style="height:2em"|
|- style="height:2em"| rowspan=3 | Re-elected in 1952.| rowspan=3 | 24|
|- style="height:2em"| | rowspan=3 | 24| rowspan=3 | Re-elected in 1954.
|- style="height:2em"|
|- style="height:2em"| rowspan=3 | Re-elected in 1958.| rowspan=3 | 25|
|- style="height:2em"| | rowspan=3 | 25| rowspan=3 | Re-elected in 1960.
|- style="height:2em"|
|- style="height:2em"| rowspan=3 | Re-elected in 1964.| rowspan=3 | 26|
|- style="height:2em"| | rowspan=3 | 26| rowspan=3 | Re-elected in 1966.
|- style="height:2em"|
|- style="height:2em"| rowspan=3 | Re-elected in 1970.| rowspan=3 | 27|
|- style="height:2em"| | rowspan=4 | 27| rowspan=3 | Re-elected in 1972.Retired, and resigned early to give successor preferential seniority.
|- style="height:2em"|
|- style="height:2em"| rowspan=4 | Re-elected in 1976.| rowspan=4 | 28|
|- style="height:2em"| Appointed early to finish Eastland's term, having already been elected to the next term.| rowspan=23 nowrap | Dec 27, 1978 –
Apr 1, 2018| rowspan=23 | Republican| rowspan=23 align=right |
Thad Cochran! rowspan=23 | 25
|- style="height:2em"| | rowspan=3 | 28| rowspan=3 | Elected in 1978.
|- style="height:2em"|
|- style="height:2em"| rowspan=3 | Re-elected in 1982.Retired.| rowspan=3 | 29|
|- style="height:2em"| | rowspan=3 | 29| rowspan=3 | Re-elected in 1984.
|- style="height:2em"|
|- style="height:2em"! rowspan=10 | 24| rowspan=10 align=left |
Trent Lott| rowspan=10 | Republican| rowspan=10 nowrap | Jan 3, 1989 –
Dec 18, 2007| rowspan=3 | Elected in 1988.| rowspan=3 | 30|
|- style="height:2em"| | rowspan=3 | 30| rowspan=3 | Re-elected in 1990.
|- style="height:2em"|
|- style="height:2em"| rowspan=3 | Re-elected in 1994.| rowspan=3 | 31|
|- style="height:2em"| | rowspan=3 | 31| rowspan=3 | Re-elected in 1996.
|- style="height:2em"|
|- style="height:2em"| rowspan=3 | Re-elected in 2000.| rowspan=3 | 32|
|- style="height:2em"| | rowspan=5 | 32| rowspan=5 | Re-elected in 2002.
|- style="height:2em"|
|- style="height:2em"| Re-elected in 2006.Resigned.| rowspan=5 | 33|
|- style="height:2em"| colspan=3 | Vacant| nowrap | Dec 18, 2007 –
Dec 31, 2007|
|- style="height:2em"! rowspan=10 | 25| rowspan=10 align=left |
Roger Wicker| rowspan=10 | Republican| rowspan=10 nowrap | Dec 31, 2007 –
present| rowspan=3 | Appointed to continue Lott's term.Elected in 2008 to finish Lott's term.
|- style="height:2em"| | rowspan=3 | 33| rowspan=3 | Re-elected in 2008.
|- style="height:2em"|
|- style="height:2em"| rowspan=4 | Re-elected in 2012.| rowspan=4 | 34|
|- style="height:2em"| | rowspan=4 | 34| rowspan=2 | Re-elected in 2014.Resigned.
|- style="height:2em"| rowspan=2
|- style="height:2em"| rowspan=2 | Appointed to continue Cochran's term.Elected in 2018 in runoff election to finish Cochran's term.| rowspan=5 nowrap | Apr 2, 2018 –
present| rowspan=5 | Republican| rowspan=5 align=right |
Cindy Hyde-Smith! rowspan=5 | 26
|- style="height:2em"| rowspan=3 | Re-elected in 2018.| rowspan=3 | 35|
|- style="height:2em"| | rowspan=3 | 35| rowspan=3 | Re-elected in 2020.
|- style="height:2em"|
|- style="height:2em"| rowspan=2 colspan=5 | To be determined in the 2024 election.| rowspan=2|36|
|- style="height:2em"| | 36| colspan=5 | To be determined in the 2026 election.