These singles topped the Belgian Walloon (francophone) Ultratop 40 in 2010.[1]
| Issue Date | Song | Artist |
|---|---|---|
| 2 January | "Meet Me Halfway" | The Black Eyed Peas |
| 9 January | ||
| 16 January | "Tik Tok" | Kesha |
| 23 January | ||
| 30 January | ||
| 6 February | ||
| 13 February | ||
| 20 February | ||
| 27 February | "We Are the World 25 for Haiti" | Artists for Haiti |
| 6 March | "Memories" | David Guetta featuring Kid Cudi |
| 13 March | ||
| 20 March | ||
| 27 March | ||
| 3 April | "Telephone" | Lady Gaga featuring Beyoncé |
| 10 April | ||
| 17 April | ||
| 24 April | ||
| 1 May | ||
| 8 May | "Alors on danse" | Stromae |
| 15 May | "Telephone" | Lady Gaga featuring Beyoncé |
| 22 May | "Alors on danse" | Stromae |
| 29 May | ||
| 5 June | "Me and My Guitar" | Tom Dice |
| 12 June | ||
| 19 June | "Waka Waka (This Time for Africa)" | Shakira featuring Freshlyground |
| 26 June | ||
| 3 July | ||
| 10 July | ||
| 17 July | ||
| 24 July | ||
| 31 July | ||
| 7 August | "We No Speak Americano" | Yolanda Be Cool & DCUP |
| 14 August | ||
| 21 August | ||
| 28 August | "Waka Waka (This Time for Africa)" | Shakira featuring Freshlyground |
| 4 September | "We No Speak Americano" | Yolanda Be Cool & DCUP |
| 11 September | "Love the Way You Lie" | Eminem featuring Rihanna |
| 18 September | ||
| 25 September | ||
| 2 October | "Dynamite" | Taio Cruz |
| 9 October | "Only Girl (In the World)" | Rihanna |
| 16 October | ||
| 23 October | "Barbra Streisand" | Duck Sauce |
| 30 October | "Only Girl (In the World)" | Rihanna |
| 6 November | "Loca" | Shakira featuring Dizzee Rascal |
| 13 November | ||
| 20 November | "Barbra Streisand" | Duck Sauce |
| 27 November | "The Time (Dirty Bit)" | The Black Eyed Peas |
| 4 December | ||
| 11 December | ||
| 18 December | ||
| 25 December |