This is a list of UTSA Roadrunners football players in the NFL Draft.
| B | Back | K | Kicker | NT | Nose tackle |
| C | Center | LB | Linebacker | FB | Fullback |
| DB | Defensive back | P | Punter | HB | Halfback |
| DE | Defensive end | QB | Quarterback | WR | Wide receiver |
| DT | Defensive tackle | RB | Running back | G | Guard |
| E | End | T | Offensive tackle | TE | Tight end |
| Year | Round | Pick | Overall | Player | Team | Position |
|---|---|---|---|---|---|---|
| 2016 | 6 | 13 | 188 | David Morgan II | Minnesota Vikings | TE |
| 2018 | 1 | 14 | 14 | Marcus Davenport | New Orleans Saints | DE |
| 2022 | 4 | 29 | 134 | Spencer Burford | San Francisco 49ers | T |
| 5 | 10 | 153 | Tariq Woolen | Seattle Seahawks | CB | |
Note: No drafts held before 1920
| Debut year | Player name | Position | Debut NFL/AFL team | Notes |
|---|---|---|---|---|
| 2015 | FS | Seattle Seahawks | ||
| 2016 | DT | Dallas Cowboys | ||
| NT | Green Bay Packers | |||
| 2017 | RB | Cincinnati Bengals | ||
| 2019 | NT | Detroit Lions | ||
| LB | New York Giants | |||
| 2020 | DE | Los Angeles Rams | ||
| 2022 | RB | Las Vegas Raiders | ||
| OT | Atlanta Falcons | |||
| 2024 | WR | Jacksonville Jaguars | ||
| DE | Denver Broncos | |||
| S | Tampa Bay Buccaneers | |||