These are the Official Charts Company UK Official Indie Chart number one hits of 2001.[1]
| Issue date | Song | Artist | |
|---|---|---|---|
| 6 January | "Can We Fix It?" | Bob the Builder | |
| 13 January | "It's the Way You Make Me Feel" | Steps | |
| 13 January | |||
| 20 January | "Buck Rogers" | Feeder | |
| 27 January | |||
| 3 February | "Oh No" | Mos Def with Pharoahe Monch & Nate Dogg | |
| 10 February | "Shining Light" | Ash | |
| 17 February | "Stutter" | Joe | |
| 24 February | "The Call" | Backstreet Boys | |
| 3 March | "Stutter" | Joe | |
| 10 March | "The Vision" | Mario Più Pts. DJ Arabesque | |
| 17 March | |||
| 24 March | "Plug In Baby" | Muse | |
| 31 March | "Mr. Writer" | Stereophonics | |
| 7 April | |||
| 14 April | "Burn Baby Burn" | Ash | |
| 21 April | "Flesh" | Jan Johnson | |
| 28 April | "Straight Up (No Bends)" | Brian Harvey | |
| 5 May | "Dream On" | Depeche Mode | |
| 12 May | "Strange World" | Push | |
| 19 May | "Pissing in the Wind" | Badly Drawn Boy | |
| 26 May | "Ya Don't See the Signs" | Mark B & Blade | |
| 2 June | "Star 69" | Fat Boy Slim | |
| 9 June | "No Flow" | Lisa Roxanne | |
| 16 June | "Romeo" | Basement Jaxx | |
| 23 June | "Have a Nice Day" | Stereophonics | |
| 30 June | "Romeo" | Basement Jaxx | |
| 7 July | "Hard to Explain" | The Strokes | |
| 14 July | "Turn" | Feeder | |
| 21 July | "Pop" | NSYNC | |
| 28 July | |||
| 4 August | "Do the Lollipop" | Tweenies | |
| 11 August | "I Feel Loved" | Depeche Mode | |
| 18 August | "Hidden Place" | Björk | |
| 25 August | "Superstylin'" | Groove Armada | |
| 1 September | |||
| 8 September | |||
| 15 September | "Mambo No. 5" | Bob the Builder | |
| 22 September | |||
| 29 September | |||
| 6 October | "Chain Reaction/One for Sorrow" | Steps | |
| 13 October | |||
| 20 October | |||
| 27 October | "I'm a Slave 4 U" | Britney Spears | |
| 3 November | |||
| 10 November | |||
| 17 November | "Last Nite" | The Strokes | |
| 24 November | "Hotel Yorba" | The White Stripes | |
| 1 December | "Hyper Music" | Muse | |
| 8 December | "ResuRection" | PPK | |
| 15 December | "Handbags and Gladrags" | The Stereophonics | |
| 22 December | |||
| 29 December | "How Wonderful You Are" | Gordon Haskell |