These are the Official Charts Company UK Official Indie Chart number one hits of 2000.[1]
| Issue date | Song | Artist |
|---|---|---|
| 1 January | "Say You'll Be Mine" | Steps |
| 8 January | ||
| 15 January | ||
| 22 January | "Rainbow Country" | |
| 29 January | "Born to Make You Happy" | Britney Spears |
| 5 February | ||
| 12 February | ||
| 19 February | "Go Let It Out" | Oasis |
| 26 February | ||
| 4 March | "Movin' Too Fast" | Artful Dodger |
| 11 March | ||
| 18 March | "Mama Told Me Not to Come" | Tom Jones featuring Stereophonics |
| 25 March | ||
| 1 April | "The Time Is Now" | Moloko |
| 8 April | ||
| 15 April | "Blow Ya Mind" | Lock 'n' Load |
| 22 April | ||
| 29 April | "Who Feels Love?" | Oasis |
| 6 May | "Blow Your Mind" | Lock "n" Load |
| 13 May | "Oops!... I Did It Again" | Britney Spears |
| 20 May | ||
| 27 May | ||
| 3 June | ||
| 10 June | ||
| 17 June | "Unintended" | Muse |
| 24 June | "Sandstorm" | Darude |
| 1 July | ||
| 8 July | ||
| 15 July | "Sunday Morning Call" | Oasis |
| 22 July | "When I Said Goodbye" | Steps |
| 29 July | "Sing-A-Long" | Shanks & Bigfoot |
| 5 August | "Sandstorm" | Darude |
| 12 August | "Battle" | Wookie featuring Lain Gray |
| 19 August | ||
| 26 August | "Lucky" | Britney Spears |
| 2 September | ||
| 9 September | "Bullet in the Gun 2000" | Planet Perfecto |
| 16 September | ||
| 23 September | "Ubik" | Timo Maas |
| 30 September | "You Take My Breath Away" | SuReal |
| 7 October | "Silence" | Delerium featuring Sarah McLachlan |
| 14 October | ||
| 21 October | ||
| 28 October | ||
| 4 November | "Who Let the Dogs Out" | Baha Men |
| 11 November | ||
| 18 November | "Shape of My Heart" | Backstreet Boys |
| 25 November | "Feel the Beat" | Darude |
| 2 December | "Who Let the Dogs Out" | Baha Men |
| 9 December | ||
| 16 December | "Can We Fix It?" | Bob The Builder |
| 23 December | ||
| 30 December |