This is the list of the number ones on the UK Independent Singles Breakers Chart during the 2000s.
| nth single to top the UK Independent Singles Breakers Chart | |||
| scope=row style="text-align:center;" | re | Return of a single to number one |
|---|
| scope=col | scope=col | Artist | scope=col | Single | scope=col | Record label | scope=col | Reached number one | scope=col | Weeks at number one | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| scope=row style="text-align:center;" colspan=6 | |||||||||||
| scope=row style="text-align:center;" | 1 | Lazee featuring Neverstore | "Hold On" | Hard2Beat | 2 | ||||||
| scope=row style="text-align:center;" | 2 | Master Shortie | "Dead End" | Odd One Out | 2 | ||||||
| scope=row style="text-align:center;" | 3 | Friendly Fires | "Jump in the Pool" | XL | 1 | ||||||
| scope=row style="text-align:center;" | 4 | Sub Focus | "Rock It" / "Follow the Light" | RAM | 2 | ||||||
| scope=row style="text-align:center;" | 5 | "Sweet Disposition" | Infectious | 4 | |||||||
| scope=row style="text-align:center;" | 6 | Friendly Fires | "Kiss of Life" | XL | 1 | ||||||
| scope=row style="text-align:center;" | Sub Focus | "Rock It" / "Follow the Light" | RAM | 2 | |||||||
| scope=row style="text-align:center;" | 7 | All Time Low | "Weightless" | Hopeless | 1 | ||||||
| scope=row style="text-align:center;" | 8 | "Dominos" | 4AD | 3 | |||||||
| scope=row style="text-align:center;" | 9 | Duck Sauce | "aNYway" | Data | 2 | ||||||
| scope=row style="text-align:center;" | 10 | Chartjackers | "I've Got Nothing" | Swinging Mantis | 1 | ||||||
| scope=row style="text-align:center;" | 11 | Taken by Trees | "Sweet Child o' Mine" | Rough Trade | 4 | ||||||
| scope=row style="text-align:center;" | 12 | and Aled Jones | "Silver Bells" / "Me and My Teddy Bear" | Bandaged | 1 |