These are The Official UK Charts Company UK Official Dance Chart number one hits of 2001.[1] The dates listed in the menus below represent the Saturday after the Sunday the chart was announced, as per the way the dates are given in chart publications such as the ones produced by Billboard, Guinness, and Virgin.
| Issue date | Song | Artist | |
|---|---|---|---|
| 6 January | "Coming Home" | K-Warren featuring Lee-O | |
| 13 January | "Komodo (Save a Soul)" | Mauro Picotto | |
| 20 January | "Camels" | Santos | |
| 27 January | "Camels" | Santos | |
| 3 February | "Boom Selection" | Genius Cru | |
| 10 February | "Boom Selection" | Genius Cru | |
| 17 February | "Synaesthesia (Fly Away)" | The Thrillseekers featuring Sheryl Deane | |
| 24 February | "American Dream" | Jakatta | |
| 3 March | "American Dream" | Jakatta | |
| 10 March | "The Vision" | Mario Più presents DJ Arabesque | |
| 17 March | "Piano Loco" | DJ Luck & MC Neat | |
| 24 March | "Dirty Beats" | Roni Size/Reprazent | |
| 31 March | "Joy" | Mark Ryder | |
| 7 April | "Salsoul Nugget (If U Wanna)" | M&S presents The Girl Next Door | |
| 14 April | "Happiness" | Sound De-Zign | |
| 21 April | "How You Like Bass" | Norman Bass | |
| 28 April | "Get Ur Freak On" | Missy Elliott | |
| 5 May | "Love Is Not a Game" | J Majik featuring Kathy Brown | |
| 12 May | "Back Up (To Me)" | Wookie featuring Lain | |
| 19 May | "Secrets" | Mutiny UK | |
| 26 May | "Up Middle Finger" | Oxide & Neutrino | |
| 2 June | "Do You Really Like It" | DJ Pied Piper and the Masters of Ceremonies | |
| 9 June | "Just Can't Get Enough (No No No No)" | Eye to Eye featuring Taka Boom | |
| 16 June | "Romeo" | Basement Jaxx | |
| 23 June | "Booo!" | Sticky featuring Ms. Dynamite | |
| 30 June | "Obsession" / "Tear Out Me Heart" | Future Cut | |
| 7 July | "Up All Night" / "Take Control" | John B | |
| 14 July | "Another Chance" | Roger Sanchez | |
| 21 July | "Castles in the Sky" | Ian Van Dahl | |
| 28 July | "Meet Her at the Love Parade" | Da Hool | |
| 4 August | "Witness (1 Hope)" | Roots Manuva | |
| 11 August | "Babarabatiri" | Gypsymen | |
| 18 August | "21 Seconds" | So Solid Crew | |
| 25 August | "Superstylin'" | Groove Armada | |
| 1 September | "Hide U" | Kosheen | |
| 8 September | "21st Century" | Weekend Players | |
| 15 September | "Body Rock" | Shimon & Andy C | |
| 22 September | "It Began in Afrika" | The Chemical Brothers | |
| 29 September | "Papua New Guinea" | Future Sound Of London | |
| 6 October | "Right On!" | Silicone Soul | |
| 13 October | "Jus 1 Kiss" | Basement Jaxx | |
| 20 October | "Flawless" | The Ones | |
| 27 October | "Sambuca" | Wideboys featuring Dennis G | |
| 3 November | "Sambuca" | Wideboys featuring Dennis G | |
| 10 November | "Rapture" | iiO | |
| 17 November | "They Don't Know" | So Solid Crew | |
| 24 November | "They Don't Know" | So Solid Crew | |
| 1 December | "Thunderball" / "Lazy Bones" | Moving Fusion | |
| 8 December | "Gotta Get Thru This" | Daniel Bedingfield | |
| 15 December | "Gotta Get Thru This" | Daniel Bedingfield | |
| 22 December | "Gotta Get Thru This" | Daniel Bedingfield | |
| 29 December | "Gotta Get Thru This" | Daniel Bedingfield |