This is a list of the Spanish PROMUSICAE Top 20 Singles number-ones of 1999.[1]
| Issue Date | Song | Artist |
|---|---|---|
| 2 January | "What's Your Sign?" | Des'ree |
| 9 January | "Believe" | Cher |
| 16 January | "What's Your Sign?" | Des'ree |
| 23 January | "Believe" | Cher |
| 30 January | "Big Big World" | Emilia |
| 6 February | ||
| 13 February | "Believe" | Cher |
| 20 February | "Maria" | Blondie |
| 27 February | "You Gotta Be" | Des'ree |
| 6 March | ||
| 13 March | "Nothing Really Matters" | Madonna |
| 20 March | ||
| 27 March | ||
| 3 April | "Promises" | The Cranberries |
| 10 April | "It's Not Right but It's Okay" | Whitney Houston |
| 17 April | "Maria" | Blondie |
| 24 April | "Salomé" | Chayanne |
| 1 May | ||
| 8 May | "I Want It That Way" | Backstreet Boys |
| 15 May | ||
| 22 May | ||
| 29 May | "Bailamos" | Enrique Iglesias |
| 5 June | ||
| 12 June | ||
| 19 June | ||
| 26 June | "DJ" | Dover |
| 3 July | "Mambo No. 5" | Lou Bega |
| 10 July | ||
| 17 July | ||
| 24 July | ||
| 31 July | ||
| 7 August | ||
| 14 August | ||
| 21 August | ||
| 28 August | ||
| 4 September | ||
| 11 September | ||
| 18 September | ||
| 25 September | "Bailamos" | Enrique Iglesias |
| 2 October | "El Extranjero" | Bunbury |
| 9 October | ||
| 16 October | "Genie in a Bottle" | Christina Aguilera |
| 23 October | ||
| 30 October | ||
| 6 November | ||
| 13 November | ||
| 20 November | ||
| 27 November | "Rhythm Divine" | Enrique Iglesias |
| 4 December | ||
| 11 December | ||
| 18 December | ||
| 25 December |