List of Schedule IV controlled substances (U.S.) explained

This is the list of Schedule IV controlled substances in the United States as defined by the Controlled Substances Act.^[1] The following findings are required for substances to be placed in this schedule:^[2]

1. The drug or other substance has a low potential for abuse relative to the drugs or other substances in schedule III.
2. The drug or other substance has a currently accepted medical use in treatment in the United States.
3. Abuse of the drug or other substance may lead to limited physical dependence or psychological dependence relative to the drugs or other substances in schedule III.

The complete list of Schedule IV substances is as follows. The Administrative Controlled Substances Code Number and Federal Register citation for each substance is included.

Narcotics

	Drug
9167	Not more than 1 milligram of difenoxin and not less than 25 micrograms of atropine sulfate per dosage unit.^[3]
9278	Dextropropoxyphene^[4]
9752	Tramadol^[5]

Depressants

	Drug
2731	Alfaxalone^[6]
2882	Alprazolam^[7]
2145	Barbital^[8]
2400	Brexanolone^[9]
2748	Bromazepam^[10]
2749	Camazepam
8192	Carisoprodol^[11]
2460	Chloral betaine
2465	Chloral hydrate
2744	Chlordiazepoxide^[12]
2751	Clobazam
2737	Clonazepam
2768	Clorazepate
2752	Clotiazepam
2753	Cloxazolam
2410	Daridorexant^[13]
2754	Delorazepam
2765	Diazepam
2467	Dichloraphenazone^[14]
2756	Estazolam
2540	Ethchlorvynol
2545	Ethinamate
2758	Ethyl loflazepate
2759	Fludiazepam
2763	Flunitrazepam^†
2767	Flurazepam
2138	Fospropofol^[15]
2762	Halazepam^[16]
2771	Haloxazolam
2772	Ketazolam
2245	Lemborexant^[17]
2773	Loprazolam
2885	Lorazepam^[18]
2774	Lormetazepam
2800	Mebutamate^[19]
2836	Medazepam
2820	Meprobamate
2264	Methohexital
2250	Methylphenobarbital (mephobarbital)
2884	Midazolam^[20]
2837	Nimetazepam
2834	Nitrazepam
2838	Nordiazepam
2835	Oxazepam
2839	Oxazolam
2585	Paraldehyde
2591	Petrichloral
2285	Phenobarbital
2883	Pinazepam
2764	Prazepam^[21]
2881	Quazepam
2846	Remimazolam^[22]
2223	Suvorexant^[23]
2925	Temazepam^†^[24]
2886	Tetrazepam
2887	Triazolam^[25]
2781	Zaleplon^[26]
2783	Zolpidem^[27]
2784	Zopiclone^[28]
2420	Zuranolone^[29]

^†Flunitrazepam has not been approved by the Food and Drug Administration for medical use, and is considered to be an illegal drug.

^†Temazepam may require a specially coded prescription in certain States.

Stimulants

	Drug
1230	Cathine^[31]
1610	Diethylpropion^[32]
1760	Fencamfamin
1575	Fenproporex
1605	Mazindol^[33]
1580	Mefenorex
1680	Modafinil and enantiopure armodafinil^[34]
1530	Pemoline^[35]
1640	Phentermine
1750	Pipradrol^[36]
1729	Serdexmethylphenidate^[37]
1675	Sibutramine^[38]
1650	Solriamfetol^[39]
1635	SPA / (-)-1-dimethylamino- 1,2-diphenylethane

Others

	Drug
9709	Pentazocine^[40]
9720	Butorphanol^[41]
9725	Eluxadoline^[42]

See also

• List of Schedule I controlled substances (U.S.)
• List of Schedule II controlled substances (U.S.)
• List of Schedule III controlled substances (U.S.)
• List of Schedule V controlled substances (U.S.)

Notes and References

1. Web site: 21 CFR 1308.14 (Schedule IV) . September 9, 2023 . Code of Federal Regulations.
2. retrieved October 2, 2007
3. Web site: Bensinger . Peter . August 28, 1978 . Placement of Preparations Containing Difenoxin in Combination With Atropine Sulfate Into Schedules IV and V . live . https://web.archive.org/web/20220303023202/http://isomerdesign.com/Cdsa/FR/43FR38382.pdf . March 3, 2022 . January 16, 2023 . Isomer Design . Drug Enforcement Administration.
4. Web site: Bensinger . Peter . July 24, 1980 . Classification of Dextropropoxyphene as a Narcotic Drug in Schedule IV of the Controlled Substances Act . live . https://web.archive.org/web/20220303023125/http://isomerdesign.com/Cdsa/FR/45FR42264.pdf . March 3, 2022 . January 16, 2023 . Isomer Design . Drug Enforcement Administration.
5. Web site: Harrigan . Thomas . July 2, 2014 . Schedules of Controlled Substances: Placement of Tramadol Into Schedule IV . January 16, 2023 . Federal Register . Drug Enforcement Administration.
6. Web site: Leonhart . Michele . February 27, 2014 . Schedules of Controlled Substances: Placement of Alfaxalone into Schedule IV . January 16, 2023 . . Drug Enforcement Administration.
7. Web site: Mullen, Jr. . Francis M. . November 12, 1981 . Schedules of Controlled Substsnces; Placement of Alprazolam in Schedule IV . live . https://web.archive.org/web/20220303023145/http://isomerdesign.com/Cdsa/FR/46FR55688.pdf . March 3, 2022 . January 16, 2023 . Isomer Design . Drug Enforcement Administration.
8. Web site: Bartels Jr. . John R. . June 20, 1974 . PART 1308— SCHEDULES OF CONTROLLED SUBSTANCES: Annual Publication . https://web.archive.org/web/20230906194000/https://archives.federalregister.gov/issue_slice/1974/6/20/22139-22143.pdf . September 6, 2023 . September 6, 2023 . . Drug Enforcement Administration.
9. Web site: Dhillon . Uttam . January 24, 2020 . Schedules of Controlled Substances: Placement of Brexanolone in Schedule IV . September 6, 2023 . . Drug Enforcement Administration.
10. Web site: Mullen, Jr. . Francis M. . October 5, 1984 . Schedules of Controlled Substances; Temporary Placement of Bromazepam, Camazepam, Clobazam, Clotiazepam, Cloxazolam, Delorazepam, Estazolam, Ethyl Loflazepate, Fludiazepam, Flunitrazepam, Haloxazolam, Ketazolam, Loprazolam, Lormetazepam, Medazepam, Nimetazepam, Nitrazepam, Nordiazepam, Oxazolam, Pinazepam, and Tetrazepam Into Schedule IV . live . https://web.archive.org/web/20220303023103/http://isomerdesign.com/Cdsa/FR/49FR39307.pdf . March 3, 2022 . January 16, 2023 . Isomer Design . Drug Enforcement Administration.
11. Web site: Leonhart . Michele . December 12, 2011 . Schedules of Controlled Substances: Placement of Carisoprodol Into Schedule IV . January 16, 2023 . . Drug Enforcement Administration.
12. Web site: Bartels, Jr. . John R. . May 28, 1975 . Schedules of Controlled Substances; Placement of Chlordiazepoxide, Diazepam, Oxazepam, Chlorazepate, Flurazepam, and Clonazepam into Schedule IV . live . https://web.archive.org/web/20220303023101/http://isomerdesign.com/Cdsa/FR/40FR23998.pdf . March 3, 2022 . January 16, 2023 . Isomer Design . Drug Enforcement Administration.
13. Web site: Milgram . Anne . April 7, 2022 . Schedules of Controlled Substances: Placement of Daridorexant in Schedule IV . January 16, 2023 . . Drug Enforcement Administration.
14. Web site: Simpkins . William . August 16, 2001 . Schedules of controlled substances: Dichloralphenazone; placement into Schedule IV . live . https://archive.today/20230116114000/https://regulations.vlex.com/vid/schedules-dichloralphenazone-placement-22950329 . January 16, 2023 . January 16, 2023 . VLEX . Drug Enforcement Administration.
15. Web site: Leonhart . Michele . October 6, 2009 . Schedules of Controlled Substances; Placement of Fospropofol Into Schedule IV . January 16, 2023 . . Drug Enforcement Administration.
16. Web site: Mullen, Jr. . Francis M. . October 29, 1981 . Schedules of Controlled Substances: Placement of Halazepam in Schedule IV . live . https://web.archive.org/web/20220303023138/http://isomerdesign.com/Cdsa/FR/46FR53407.pdf . March 3, 2022 . January 16, 2023 . Isomer Design . Drug Enforcement Administration.
17. Web site: Evans . D. Christopher . March 3, 2021 . Schedules of Controlled Substances: Placement of Lemborexant in Schedule IV . January 16, 2023 . . Drug Enforcement Administration.
18. Web site: Bensinger . Peter . October 7, 1977 . Placement of Lorazepam in Schedule IV . live . https://web.archive.org/web/20220303023055/http://isomerdesign.com/Cdsa/FR/42FR54546.pdf . March 3, 2022 . January 16, 2023 . Isomer Design . Drug Enforcement Administration.
19. Web site: Bartels, Jr. . John R. . January 30, 1975 . Placement of Mebutamate in Schedule IV . live . https://web.archive.org/web/20220303023155/http://isomerdesign.com/Cdsa/FR/40FR4418.pdf . March 3, 2022 . January 16, 2022 . Isomer Design . Drug Enforcement Administration.
20. Web site: Lawn . John . March 25, 1986 . Schedules of Controlled Substances; Placement of Quazepam and Midazolam into Schedule IV . live . https://web.archive.org/web/20220303023138/http://isomerdesign.com/Cdsa/FR/51FR10190.pdf . March 3, 2022 . January 16, 2023 . Isomer Design . Drug Enforcement Administration.
21. Web site: Bensinger . Peter . December 17, 1976 . Placement of Prazepam into Schedule IV . live . https://web.archive.org/web/20220303023350/http://isomerdesign.com/Cdsa/FR/41FR55176.pdf . March 3, 2022 . January 16, 2023 . Isomer Design . Drug Enforcement Administration.
22. Web site: Evans . D. Christopher . July 2, 2021 . Schedules of Controlled Substances: Placement of Remimazolam in Schedule IV . September 6, 2023 . . Drug Enforcement Administration.
23. Web site: Harrigan . Thomas . August 28, 2014 . Schedules of Controlled Substances: Placement of Suvorexant into Schedule IV . January 16, 2023 . . Drug Enforcement Administration.
24. Web site: Bensinger . Peter . April 7, 1981 . Schedules of Controlled Substances; Placement of Temazepam into Schedule IV . live . https://web.archive.org/web/20220303023143/http://isomerdesign.com/Cdsa/FR/46FR20671.pdf . March 3, 2022 . January 16, 2023 . Isomer Design . Drug Enforcement Administration.
25. Web site: Mullen, Jr. . Francis M. . December 28, 1982 . Schedules of Controlled Substances; Placement of Triazolam into Schedule IV . live . https://web.archive.org/web/20220303023131/http://isomerdesign.com/Cdsa/FR/47FR57693.pdf . March 3, 2022 . January 16, 2023 . Isomer Design . Drug Enforcement Administration.
26. Web site: Marshall . Donnie . September 15, 1999 . Schedules of Controlled Substances; Placement of Zaleplon into Schedule IV . January 16, 2023 . . Drug Enforcement Administration.
27. Web site: Bonner . Robert . February 5, 1993 . Schedules of Controlled Substances; Placement of Zolpidem into Schedule IV . https://web.archive.org/web/20220303023130/http://isomerdesign.com/Cdsa/FR/58FR7186.pdf . March 3, 2022 . January 16, 2023 . Isomer Design . Drug Enforcement Administration.
28. Web site: Leonhart . Michele . April 4, 2005 . Schedules of Controlled Substances: Placement of Zopiclone Into Schedule IV . . Drug Enforcement Administration.
29. Web site: Milgram . Anne . October 31, 2023 . Schedules of Controlled Substances: Placement of Zuranolone in Schedule IV . November 3, 2023 . . Drug Enforcement Administration.
30. Web site: Leonhart . Michele . May 8, 2013 . Schedules of Controlled Substances: Placement of Lorcaserin Into Schedule IV . January 16, 2023 . Federal Register . Drug Enforcement Administration.
31. Web site: Lawn . John . May 17, 1988 . Schedules of Controlled Substances; Temporary Placement of Cathine ((+)-norpseudoephedrine), Fencamfamin, Fenproporex and Mefenorex Into Schedule IV . https://web.archive.org/web/20220303023140/http://isomerdesign.com/Cdsa/FR/53FR17459.pdf . March 3, 2022 . January 16, 2023 . Isomer Design . Drug Enforcement Administration.
32. Web site: Ingersoll . John . July 6, 1973 . Diethylpropion and Phentermine; Temporary Placement in Schedule IV . live . https://web.archive.org/web/20220303023151/http://isomerdesign.com/Cdsa/FR/38FR18013.pdf . March 3, 2022 . January 16, 2023 . Isomer Design . Bureau of Narcotics and Dangerous Drugs.
33. Web site: Mullen, Jr. . Francis M. . October 27, 1981 . Rescheduling of Mazindol into Schedule IV . live . https://web.archive.org/web/20210926012035/http://www.isomerdesign.com/Cdsa/FR/46FR52333.pdf . September 26, 2021 . January 16, 2023 . Isomer Design . Drug Enforcement Administration.
34. Web site: Marshall . Donnie . January 27, 1999 . Schedules of Controlled Substances: Placement of Modafinil Into Schedule IV . . Drug Enforcement Administration.
35. Web site: Bartels, Jr. . John R. . January 28, 1975 . Placement of Pemoline in Schedule IV . live . https://web.archive.org/web/20220303023110/http://isomerdesign.com/Cdsa/FR/40FR4150.pdf . March 3, 2022 . January 16, 2023 . Isomer Design . Drug Enforcement Administration.
36. Web site: Bensinger . Peter . September 30, 1980 . Pipradrol and SPA in Schedule IV . live . https://web.archive.org/web/20220303023219/http://isomerdesign.com/Cdsa/FR/45FR64570.pdf . March 3, 2022 . January 16, 2023 . Isomer Design . Drug Enforcement Administration.
37. Web site: Milgram . Anne . July 25, 2022 . Schedules of Controlled Substances: Placement of Serdexmethylphenidate in Schedule IV . September 6, 2023 . . Drug Enforcement Administration.
38. Web site: Gruden . Peter . February 11, 1998 . Schedules of Controlled Substances: Placement of Sibutramine Into Schedule IV . January 16, 2023 . . Drug Enforcement Administration.
39. Web site: Dhillon . Uttam . January 7, 2020 . Schedules of Controlled Substances: Placement of Solriamfetol in Schedule IV . January 16, 2023 . . Drug Enforcement Administration.
40. Web site: Bensinger . Peter . February 9, 1979 . Placement of Pentazocine into Schedule IV . live . https://web.archive.org/web/20220303023302/http://isomerdesign.com/Cdsa/FR/44FR2169.pdf . March 3, 2022 . January 16, 2023 . Isomer Design . Drug Enforcement Administration.
41. Web site: Milford, Jr. . James S. . October 31, 1997 . Schedules of Controlled Substances Placement of Butorphanol Into Schedule IV . live . https://ghostarchive.org/archive/20230116090131/https://www.govinfo.gov/content/pkg/FR-1997-10-01/html/97-25969.htm . January 16, 2023 . January 16, 2023 . . Drug Enforcement Administration.
42. Web site: Rosenberg . Chuck . November 12, 2015 . Schedules of Controlled Substances: Placement of Eluxadoline Into Schedule IV . live . https://archive.today/20230116092225/https://www.federalregister.gov/documents/2015/11/12/2015-28718/schedules-of-controlled-substances-placement-of-eluxadoline-into-schedule-iv . January 16, 2023 . January 16, 2023 . . Drug Enforcement Administration.