| Post: | grand vizier |
| Body: | Safavid Iran |
| Insigniasize: | 150px |
| Appointer: | The Shah |
| Formation: | 1501 |
| First: | Amir Zakariya |
| Last: | Rajab-Ali Khan |
| Abolished: | 8 March 1736 |
This is the list of grand viziers (vazīr-e azam) of Safavid Iran.
| Name | Entered office | Left office | Ethnicity | Family/tribe | Monarch |
|---|---|---|---|---|---|
| Amir Zakariya | 1501 | 1507 | Persian | Kujuji family | Ismail I |
| Mahmud Jan Daylami | 1502/3 | 1507 | Persian | Daylami family | |
| Najm-e Sani | 1507 | 1510 | Persian | Khuzani family | |
| Hossein Monshi Qomi | 1510 | 1514 | Persian | ||
| Mirza Shah Hossein | 1514 | 1523 | Persian | ||
| Jalal al-Din Mohammad Tabrizi | 1523 | 1524 | Persian | Kujuji family | Ismail I, Tahmasp I |
| Mirza Jafar Savaji | 1524 | 1531 | Persian | Savaji family | Tahmasp I |
| Ahmad Beg Nur Kamal | 1523 | 1534 | Persian | ||
| Mir Enayat Allah Khuzani | 1534 | 1535 | Persian | Khuzani family | |
| Kvajeh Mo'en Yazdi | 1534 | 1535 | Persian | ||
| Qadi Jahan Qazvini | 1534 | 1551 | Persian | ||
| Mir Sharif Shirazi | 1562 | 1566 | Persian | ||
| Ma'sum Beg Safavi | 1553 | 1568 | Persian | Shaykhavand family | |
| Jamal al-Din Ali Tabrizi | 1568 | ? | Unknown | ||
| Sayyed Hasan Farahani | ? | 1576 | Unknown | ||
| Mirza Shokrollah Isfahani | 1576 | June 1577 | Persian | Ismail II | |
| Mirza Salman Jaberi | June 13, 1577 | 1583 | Persian | Jaberi family | Ismail II, Mohammad Khodabanda |
| Mirza Hedayatollah | 1583 | 1586 | Persian | Khuzani family | Mohammad Khodabanda |
| Mirza Mohammad Monshi | 1586 | 1587 | Persian | ||
| Mirza Shah Vali Isfahani | 1587 | 1587 | Persian | Abbas I | |
| Mirza Lotfi | 1587 | 1588 | Persian | ||
| Mirza Mohammad Monshi | 1588 | 1589 | Persian | ||
| Mirza Lotfollah Shirazi | 1589 | 1591 | Persian | ||
| Hatem Beg Ordubadi | 1591 | 1610/1 | Persian | Ordubadi family | |
| Mirza Taleb Khan Ordubadi | 1610/1 | 1621 | Persian | Ordubadi family | |
| Salman Khan Ustajlu | 1621 | 1623/4 | Turkoman | Ustajlu tribe | |
| Khalifeh Soltan | 1623/4 | 1632 | Persian-Mazandarani | Khalifeh family | Abbas I, Safi |
| Mirza Taleb Khan Ordubadi | 1632 | 1633 | Persian | Ordubadi family | Safi |
| Saru Taqi | 1633 | 11 October 1645 | Unknown | Safi, Abbas II | |
| Khalifeh Soltan | 14 October 1645 | 5 March 1654 | Persian-Mazandarani | Khalifeh family | Abbas II |
| Mohammad Beg | 1654 | January 25, 1661 | Armenian | ||
| Mirza Mohammad Karaki | March 11, 1661 | 1669 | Persian | Karaki family | Abbas II, Suleiman I |
| Shaykh Ali Khan Zanganeh | 1669 | 25 October 1689 | Kurdish | Zanganeh tribe | Suleiman I |
| Mohammad Taher Qazvini | March 1691 | 1699 | Persian | Suleiman I, Sultan Husayn | |
| Mohammad Mo'men Khan Shamlu | 1699 | 1707 | Turkoman | Shamlu tribe | Sultan Husayn |
| Shahqoli Khan Zanganeh | 1707 | 1716 | Kurdish | Zanganeh tribe | |
| Fath-Ali Khan Daghestani | 1716 | 1720 | Lezgian | Shamkhal of Kumukh | |
| Mohammad Qoli Khan Shamlu | January 1721 | 1722 | Turkoman | Shamlu tribe | |
| Rajab Ali Beg | 1722 | 1722 | Unknown | Tahmasp II | |
| Mohammad Ali Khan Mokri | 1722 | 1723 | Kurdish | Mukri tribe | |
| Mortezaqoli Khan | 1722 | 1723 | Unknown | ||
| Mirza Abdol-Karim | 1723 | 1724 | Unknown | ||
| Farajollah Khan Abdollah | ? | ? | Unknown | ||
| Mirza Mohammad Hossein | ? | ? | Unknown | ||
| Mirza Abdollah | 1724 | 1725 | Unknown | ||
| Mirza Mo'men Qazvini | 1725 | 1728 | Unknown | ||
| Mirza Mohammad Rahim | 1728 | 1730 | Unknown | ||
| Rajab Ali Khan | 1731 | 1731 | Unknown | ||