List of SJS-inducing substances explained

This is a list of drugs and substances that are known or suspected to cause Stevens–Johnson syndrome.

Name Other names
Allopurinol[1]
Amoxicillin[2]
Ampicillin
Azithromycin[3] Zithromax
Barbiturates[4]
Carbamazepine[5]
Ciprofloxacin/levofloxacin/Gemifloxacin
Clozapine[6] Clozaril
Cotrimoxazole[7] Trimethoprim/sulfamethoxazole
Diclofenac[8]
Ethosuximide
Glutathione[9]
Ibuprofen[10]
Isotretinoin[11] Accutane
Lamotrigine[12] Lamictal
Modafinil[13] Provigil
Nevirapine
Norfloxacin[14]
Oseltamivir
OxicamsAmpiroxicam, Piroxicam, Tenoxicam, Droxicam, Lornoxicam, Meloxicam, Isoxicam
Paracetamol[15] [16] Acetaminophen, Panadol, Tylenol
Penicillins
Phenytoin
Rivoraxaban[17] Xarelto
Sitagliptin
Sulfonamides
Tetracycline

Notes and References

  1. Book: Harr T, French LE . Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis . Adverse Cutaneous Drug Eruptions . Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis . Chem Immunol Allergy . 97 . 1 . 149–166 . 2012 . 22613860 . 10.1159/000335627. 978-3-8055-9970-2 .
  2. Web site: Stevens Johnson Syndrome. WebMD.
  3. See, e.g.: Web site: Potential Zithromax Side Effects Include Stevens Johnson Syndrome . Schultz, Laura . Top Class Actions, LLC . December 28, 2015 . https://web.archive.org/web/20160304073128/http://topclassactions.com/lawsuit-settlements/lawsuit-news/255241-potential-zithromax-side-effects/ . March 4, 2016 . December 28, 2015 . live . Several Zithromax lawsuits have been filed against Pfizer alleging that the drug maker failed to warn the medical community and the public about serious risks associated with taking the antibiotic. .
  4. Mamishi. Setareh. Fattahi. Fatemeh. Pourpak. Zahra. Aghaee. Farzaneh Mirza. Moinfar. Zeinab. Mohammadi. Mahmoud. Ashrafi. Mahmoud. Moin. Mostafa. 2009-11-01. Severe cutaneous reactions caused by barbiturates in seven Iranian children. International Journal of Dermatology. 48. 11. 1254–1261. 10.1111/j.1365-4632.2007.03561.x. 1365-4632. 20064188. 10117062 . free.
  5. Web site: Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN). Rehmus. Wingfield E. November 2013. Merck Manual. Merck Sharp & Dohme Corp.
  6. Wu. Ming-Kung. Chung. Weilun. Wu. Ching-Kuan. Tseng. Ping-Tao. 2015-01-01. The severe complication of Stevens-Johnson syndrome induced by long-term clozapine treatment in a male schizophrenia patient: a case report. Neuropsychiatric Disease and Treatment. 11. 1039–1041. 10.2147/NDT.S79327. 1176-6328. 4399514. 25914536 . free .
  7. 10.1038/sj.jid.5701033. 17805350. 0022-202X. 128. 1. 35–44. Mockenhaupt. Maja. Viboud. Cecile . Cécile Viboud. Dunant. Ariane. Naldi. Luigi. Halevy. Sima. Bavinck. Jan Nico Bouwes. Sidoroff. Alexis. Schneck. Jürgen. Roujeau. Jean-Claude. Flahault. Antoine. Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: Assessment of Medication Risks with Emphasis on Recently Marketed Drugs. The EuroSCAR-Study. Journal of Investigative Dermatology. 2008-01-01. free.
  8. Roujeau, J.-C., Kelly, J. P., Naldi, L., Rzany, B., Stern, R. S., Anderson, T., Auquier, A., Bastuji-Garin, S., Correia, O., Locati, F., Mockenhaupt, M., Paoletti, C., Shapiro, S., Shear, N., Schopf, E., Kaufman, D. W. . Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis. . N Engl J Med . 333 . 1 . 1600–1607 . 1995 . 7477195 . 10.1056/NEJM199512143332404. free .
  9. Web site: Safety of off label use of Glutathione Injection.
  10. Raksha MP, Marfatia YS . Clinical study of cutaneous drug eruptions in 200 patients . Indian J Dermatol Venereol Leprol . 74 . 1 . 80 . 2008 . 18193504 . 10.4103/0378-6323.38431. free . 1807/48058 . free .
  11. http://www.medsafe.govt.nz/profs/Datasheet/d/DiflucanOnecap.htm Medsafe Data Sheet
  12. Web site: LAMICTAL PRESCRIBING INFORMATION. GlaxoSmithKline. 2009-12-17. https://web.archive.org/web/20060913102944/http://us.gsk.com/products/assets/us_lamictal.pdf. 2006-09-13. dead.
  13. Web site: PROVIGIL PRESCRIBING INFORMATION . Cephalon, Inc. . dead . https://web.archive.org/web/20150501213830/http://www.provigil.com/media/PDFs/prescribing_info.pdf . 2015-05-01 .
  14. Web site: Norfloxacin . March 24, 2017 . Davis . 2017 . October 27, 2017 . https://web.archive.org/web/20171027125502/https://davisplus.fadavis.com/3976/meddeck/pdf/norfloxacin.pdf . dead .
  15. Acetaminophen-induced Steven Johnson syndrome-toxic epidermal necrolysis overlap. J Pak Med Assoc . 22755330 . 62. 5 . May 2012. 524–7. Khawaja A, Shahab A, Hussain SA .
  16. Web site: Stevens-Jonhson syndrome after acetaminophen ingestion, confirmed by challenge test in an eleven-year-old patient. the Journal: Allergologia et Immunopathologia.
  17. Web site: Scientific conclusions and grounds for the variation to the terms of the marketing authorisation(s). data sheet . European Medicines Agency. 6 April 2017.

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