This is a list of the largest cities in Nicaragua by population.
| 2021 class | City | Department | 2021 Population [1] | |
|---|---|---|---|---|
| 1 | Managua | Managua Department | 1,047,286 | |
| 2 | León | León Department | 175,026 | |
| 3 | Tipitapa | Managua Department | 144,187 | |
| 4 | Masaya | Masaya Department | 136,584 | |
| 5 | Ciudad Sandino | Managua Department | 124,702 | |
| 6 | Chinandega | Chinandega Department | 114,417 | |
| 7 | Matagalpa | Matagalpa Department | 111,258 | |
| 8 | Esteli | Esteli Department | 110,329 | |
| 9 | Granada | Granada Department | 104,980 |