This is a list of National Wildlife Refuges (NWR) established specifically for the protection of one or more endangered species.
| State | Unit name | Species of concern | Unit area (acres) | |
|---|---|---|---|---|
| 264 | ||||
| 199 | ||||
| 1,060 | ||||
| 25 | ||||
| 116,585 | ||||
| 2,765 | ||||
| 2,369 | ||||
| 124 | ||||
| 55 | ||||
| 14,054 | ||||
| 897 | ||||
| 14 | ||||
| 3,592 | ||||
| 21,524 | ||||
| 139 | ||||
| 2,471 | ||||
| 7,884 | ||||
| 1,840 | ||||
| 1,638 | ||||
| 911 | ||||
| Light-footed clapper rail | 316 | |||
| 1,023 | ||||
| 29 | ||||
| 6,686 | ||||
| 80 | ||||
| 23,379 | ||||
| 980 | ||||
| 659 | ||||
| 8,542 | ||||
| 6,255 | ||||
| 32,730 | ||||
| 917 | ||||
| 241 | ||||
| 164 | ||||
| 45 | ||||
| 691 | ||||
| 61 | ||||
| 521 | ||||
| 184 | ||||
| 6,535 | ||||
| 19,713 | ||||
| 42 | ||||
| 90 | ||||
| 65,810 | ||||
| 19 | ||||
| 13,268 | ||||
| 32 | ||||
| 2,208 | ||||
| 4,200 | ||||
| 2,750 | ||||
| 457 | ||||
| Puerto Rico | Cabo Rojo NWR | Yellow-shouldered blackbird | 1,836 | |
| Culebra NWR | Hawksbill sea turtle, leatherback sea turtle | 1,450 | ||
| Desecheo NWR | Hawksbill sea turtle, Puerto Rico applecactus | 360 | ||
| Laguna Cartagena NWR | Yellow-shouldered blackbird | 1,059 | ||
| Vieques NWR | Antillean manatee, hawksbill sea turtle, leatherback sea turtle | |||
| 1,044 | ||||
| 8,007 | ||||
| 14,144 | ||||
| 14 | ||||
| 327 | ||||
| 4,147 | ||||
| 2,276 | ||||
| 2,777 | ||||
| 1,776 |